The Emergence of Clinical Research Ethics Consultation: Insights From a National Collaborative

The increasing complexity of human subjects research and its oversight has prompted researchers, as well as institutional review boards (IRBs), to have a forum in which to discuss challenging or novel ethical issues not fully addressed by regulations. Research ethics consultation (REC) services provide such a forum. In this article, we rely on the experiences of a national Research Ethics Consultation Collaborative that collected more than 350 research ethics consultations in a repository and published 18 challenging cases with accompanying ethical commentaries to highlight four contexts in which REC can be a valuable resource. REC assists: 1) investigators before and after the regulatory review; 2) investigators, IRBs, and other research administrators facing challenging and novel ethical issues; 3) IRBs and investigators with the increasing challenges of informed consent and risk/benefit analysis; and 4) in providing flexible and collaborative assistance to overcome study hurdles, mediate conflicts within a team, or directly engage with research participants. Institutions that have established, or plan to establish, REC services should work to raise the visibility of their service and engage in open communication with existing clinical ethics consult services as well as the IRB. While the IRB system remains the foundation for the ethical review of research, REC can be a valuable service for investigators, regulators, and research participants aligned with the goal of supporting ethical research.     

Statistical properties of four effect-size measures for mediation models

This project examined the performance of classical and Bayesian estimators of four effect size measures for the indirect effect in a single-mediator model and a two-mediator model. Compared to the proportion and ratio mediation effect sizes, standardized mediation effect-size measures were relatively unbiased and efficient in the single-mediator model and the two-mediator model. Percentile and bias-corrected bootstrap interval estimates of ab/s _Y , and ab(s _X )/s _Y in the single-mediator model outperformed interval estimates of the proportion and ratio effect sizes in terms of power, Type I error rate, coverage, imbalance, and interval width. For the two-mediator model, standardized effect-size measures were superior to the proportion and ratio effect-size measures. Furthermore, it was found that Bayesian point and interval summaries of posterior distributions of standardized effect-size measures reduced excessive relative bias for certain parameter combinations. The standardized effect-size measures are the best effect-size measures for quantifying mediated effects.     

Maternal Harsh Parenting,SES, and Young Children’s Sleep

Journal of Child and Family Studies - There is a need to better understand the influence of daytime parenting behaviors on children’s sleep. We investigated relations between maternal harsh...     

Victim Ambiguity: Bystander Intervention and Sexual Assault in the College Drinking Scene

Alcohol-related sexual assault is the most common form of sexual victimization on college campuses. Bystander intervention has been suggested as effective in preventing sexual assault, but its usefulness in sexual assaults that involve alcohol in particular has not yet been examined. The current study draws from intensive interviews with 30 undergraduates at a large Midwestern university to understand how students’ perceptions about sexual victimization and alcohol use affect their bystander behavior. Findings suggest that in alcohol-involved situations, the ambiguity of whether the woman is at risk and her perceived worthiness are significant barriers to intervention. Policy implications are discussed.     

Brain drawings following traumatic brain injury (TBI) and links to illness perceptions and health outcomes – Findings from a population-based study

Objective: Individuals’ illness perceptions predict health behaviours and influence functional outcomes. This study examined associations between a novel assessment of illness perceptions, in the form of adult’s brain drawings after traumatic brain injury (TBI) and questionnaire measures of illness perceptions, quality of life and post-concussive symptoms.

Design: Population-based, prospective longitudinal study examining 245 adults with predominantly mild TBI with high risk of complications.

Main outcome measures: Participants were asked to draw pictures of what they thought their brain looked like before injury and at baseline and one month post-injury. Drawing characteristics (height, width and percentage damage at one month) were examined in relation to each outcome of interest at six months.

Results: Greater damage at one month was associated with more negative illness perceptions (rs = .23), poorer mental health (rs = ?.21), and more total post-concussive symptoms (rs = .27 to r = .35) at six months. The extent of damage depicted reduced over time (p < .001). No associations were found between the amount of damage drawn and injury severity, nor the height or width of drawings and injury severity or illness perceptions.

Conclusion: Drawings post-TBI offer a simple, cost- and time-effective way to begin discussions and improve understanding of peoples’ illness perceptions.     

Scope of Semantic Activation and Innovative Thinking in College Students with ADHD

Adults with attention-deficit/hyperactivity disorder (ADHD) show high divergent thinking on standardized laboratory measures. This study assessed innovative thinking in adults with ADHD using a realistic task and investigated a possible cognitive mechanism for ADHD-related advantages in innovative thinking. College students with and without ADHD (n = 30 per group) completed a cell-phone feature invention task and word association task. Latent semantic analysis was used to measure semantic distance within cue-associate pairs on the word association task. Compared to non-ADHD peers, students with ADHD scored higher in originality, novelty, and flexibility on the cell phone task, and produced associates of lower semantic relatedness on the word association task. Tests of statistical mediation confirmed that the higher flexibility of the ADHD group was explained by semantic distance within cue-associate pairs on the word association task. Results support the possibility that ADHD is positively associated with specific aspects of innovative thinking, which may in part be attributable to a wide scope of semantic activation.     

Substance-abuse prevention: Beyond the schoolyard

Substance-abuse prevention in children and youth has had limited success, possibly because the scope of traditional interventions, usually school based, is too narrow. Children who live in poverty and/or whose homes are dysfunctional need environmental changes beyond what traditional school-based programs can offer. Community psychologists need to expand their work in this area. School-based and community-based interventions are addressed. Ideas for broadening interventions to include elements such as family, media, and community collaboration are evaluated and discussed, along with successful examples of such interventions. Suggestions are made for further innovative work in this area.     

Community-delivered infant–parent psychotherapy improves maternal sensitive caregiving: Evaluation of the Michigan model of infant mental health home visiting

The current study evaluated the effectiveness of a home-based psychotherapeutic Infant Mental Health Home Visiting (IMH-HV) intervention for enhancing parenting sensitivity; a secondary aim was to evaluate whether the use of video feedback was associated with greater treatment response. Participants were N = 78 mothers and their children (age at entry ranged from prebirth to 24-month old (M = 9.8, SD = 8.4), who were initiating IMH-HV services with community mental health-based therapists (N = 51). Dyads were assessed during extended home visits via standardized interviews and observational and questionnaire methods within the first month of treatment (baseline), and again 6 and 12 months thereafter. Following each of these extended home visits, study evaluators completed a standard Q-sort to capture observations of maternal sensitivity during the visit. Therapists completed fidelity checklists used to derive the total number of IMH-HV sessions received (i.e., dosage) and frequency with which therapists provided video feedback. Results indicated a dose–response relationship between number of sessions and maternal sensitivity, and that video review with parents independently contributed to improved maternal sensitivity. Discussion focuses on the effectiveness of this community-based psychotherapeutic home visiting model for enhancing parenting, as well as the value of video feedback as a specific therapeutic strategy.