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161.
Masaya Miwa Shogo Uchida Fumika Horiba Hiroshi Takeshima Toshitaka Nabeshima Masayuki Hiramatsu 《Neurobiology of learning and memory》2010,93(3):396-405
Nociceptin binds to nociceptin opioid peptide (NOP) receptors. We reported that although high doses of nociceptin impaired memory function and that these effects were mediated via NOP receptors, low doses of nociceptin attenuated the memory impairment, and these attenuating effects were not mediated via NOP receptors. Even very low doses of nociceptin were biologically active and suggested a certain binding site for this peptide, but the mechanism underlying this attenuating effect has not yet been elucidated. In the present study, we investigated the effect of an intrahippocampal injection (i.h.) of nociceptin on memory impairment induced by U0126, a MEK inhibitor, and Rp-cAMPS, a PKA inhibitor in a step-down type passive avoidance test. U0126 (2.63 nmol/mouse, i.h.) impaired memory formation and training-dependent phosphorylation of ERK2 in the hippocampus. Co-administration of nociceptin (10 fmol/mouse) significantly attenuated memory impairment, while it did not attenuate the inhibition of training-dependent phosphorylation of ERK2 induced by U0126. On the other hand, nociceptin did not attenuate memory impairment induced by Rp-cAMPS (0.448 nmol/mouse, i.h.). Nociceptin (1 fmol/mouse) also attenuated U0126 (5.26 nmol/mouse)-induced memory impairment in NOP receptor knockout mice. Nociceptin was reported to metabolize into fragments (1–13) and (14–17) in vivo, which showed pharmacological activities without affecting NOP receptors. Our findings showed that nociceptin (14–17) (1 fmol/mouse) also attenuated U0126-induced memory impairment, while nociceptin (1–13) (0.1–10 fmol/mouse) did not attenuate memory impairment. These results suggest a novel action site or mechanism for the attenuating effects of nociceptin and its metabolite, and the sequence of nociceptin (14–17) is a critical structure. 相似文献
162.
163.
Huichao Li Takahiro Sawaguchi Kaneaki Tsuzaki Hiroshi Noguchi 《Philosophical Magazine Letters》2015,95(6):303-311
We investigated the roles of deformation-induced ε-martensitic transformation on strain-controlled low-cycle fatigue (LCF) through crack-propagation analysis involving a notching technique that used a focused ion beam (FIB) setup on Fe–30Mn–4Si–2Al austenitic steel. Using the FIB notch, we separated the microstructure evolution into macroscopic cyclic deformation-induced and crack-propagation-induced microstructures. Following this, we clarified the fatigue crack-propagation-induced ε-martensitic transformation to decelerate crack propagation at a total strain range of 2%, obtaining an extraordinary LCF life of 1.1 × 104 cycles. 相似文献
164.
Hiroshi Masuda Hirobumi Tobe Eiichi Sato Yoshito Sugino Shigeharu Ukai 《Philosophical Magazine Letters》2015,95(7):359-366
Two-dimensional grain-boundary sliding (GBS) was achieved microscopically in an oxide-dispersion-strengthened ferritic steel with an elongated and aligned grain structure, which was deformed perpendicular to the long axis. At the border between superplastic regions II and III, microscopic deformation was observed using sub-micron grids drawn on the material surface using a focused ion beam. GBS was accommodated by intragranular deformations in narrow areas around grain boundaries, which has been predicted by earlier researchers as characteristics of the core–mantle model. These observations suggest that dislocations slip only in the mantle regions around wavy boundaries to relax the stress concentration caused by GBS during superplasticity. 相似文献
165.
This study aimed to examine the influence of the presence of a partner in terms of affiliation level and role on anxiety in a physically threatening situation. In the first experiment, nine male subjects waited alone for the electric shock, and the other nine subjects waited with their partner. In the second experiment, 36 female subjects were assigned to four experimental groups by the difference of the role of a partner (coactor or audience) and the affiliation level of a partner (friend or stranger), and subjects waited for the electric shock with their partner. It was found that anxiety of subjects decreased when the partner was a coactor and/or a friend. It was suggested that these two functioned differently in anxiety reduction in a physically threatening situation. 相似文献
166.
Romi Nijhawan Katsumi Watanabe Beena Khurana Shinsuke Shimojo 《Visual cognition》2013,21(2-3):275-298
Abstract Faces and other objects that share a configuration present a special problem to the visual system. Two components of the visual system's solution to this homogeneity problem have been identified. Inversion studies have identified the use of relational features (Diamond &; Carey, 1986; Rhodes, Brake, &; Atkinson, 1993), and caricature studies have identified norm-based coding (Carey, Rhodes, Diamond, &; Hamilton, in preparation; Rhodes, Brennan, &; Carey, 1987; Rhodes &; McLean, 1990). Here we explore a possible link between these two components, asking whether caricature effects depend selectively on exaggeration of relational features. If so, then inversion, which makes relational features particularly difficult to code (compared with isolated features), should reduce caricature effects. In three experiments we found a caricature equivalence effect (caricatures identified as accurately as undistorted images and both better than anticaricatures) that was unaffected by orientation, suggesting that relational feature coding is not necessary for caricatures to be effective. Therefore, caricature and inversion effects reflect distinct components of face recognition. Caricature level and orientation also interacted differently with other factors, as would be expected if their effects depend upon different underlying processes. For one set of faces there was a caricature advantage in accuracy (Experiments 1 and 3). This superportrait effect occurred even for subjects who were unfamiliar with the faces prior to the experiment (Experiment 3), a result with important forensic implications. Furthermore, the effect was restricted to upright faces. Therefm, although caricatures can be recognized as well as undistorted images whatever features are exaggerated, exaggeration of relational features may be needed for a superportrait effect. 相似文献
167.
In this study, we examined whether visual context can be learned through a dynamic display and whether it can facilitate sustained attentional tracking by combining a multiple object tracking (MOT) task and a contextual cueing procedure. The trajectories of the targets and distractors in the MOT task were made invariant by repeatedly presenting them. The results revealed that when the targets were repeatedly displayed, tracking performance implicitly improved, and this effect was enhanced when the unattended distractors in the displays were also repeated. However, the repetition of the distractors alone did not produce any effect. Interestingly, when the targets and distractors were switched in a display in which the distractors had been previously repeated, the tracking performance was impaired as compared with that in the case of nonrepeated displays. We concluded that the contextual information in a dynamic display facilitates attentional tracking and that different types of contextual modulations occurred in MOT processes, such as facilitation for attended targets and inhibition for ignored distractors. 相似文献
168.
Hiroshi Yama 《Thinking & reasoning》2013,19(3):295-311
It has been reported as a robust effect that people are likely to select a matching case in the Wason selection task. For example, they usually select the 5 case, in the Wason selection task with the conditional “if an E, then a not-5”. This was explained by the matching bias account that people are likely to regard a matching case as relevant to the truth of the conditional (Evans, 1998). However, because a positive concept usually constructs a smaller set than its negative one does (a rarity assumption), it is more effective to get information on the truth of the conditional in a positive set than in a negative set. Thus the optimal data selection account can also explain the effect. The set size of Q and matching by introducing negation were manipulated independently in four experiments. From the results it was inferred that the so-called matching bias was an amalgam of two different cognitive components—relevance judgement by matching and optimal data selection. 相似文献
169.
Hugo Mercier Emmanuel Trouche Hiroshi Yama Christophe Heintz Vittorio Girotto 《Thinking & reasoning》2013,19(3):341-355
Many fields of study have shown that group discussion generally improves reasoning performance for a wide range of tasks. This article shows that most of the population, including specialists, does not expect group discussion to be as beneficial as it is. Six studies asked participants to solve a standard reasoning problem—the Wason selection task—and to estimate the performance of individuals working alone and in groups. We tested samples of U.S., Indian, and Japanese participants, European managers, and psychologists of reasoning. Every sample underestimated the improvement yielded by group discussion. They did so even after they had been explained the correct answer, or after they had had to solve the problem in groups. These mistaken intuitions could prevent individuals from making the best of institutions that rely on group discussion, from collaborative learning and work teams to deliberative assemblies. 相似文献
170.
Previous research indicates a positive relationship between psychopathy and various negative humor styles. The purpose of the present study was to investigate social exclusion as a possible mediator of the association between psychopathy and negative humor styles in noninstitutionalized young adults. One hundred and thirty-nine university students participated by responding to questionnaires that assess psychopathy, the experience of exclusion from friends, and four humor styles (self-enhancing, affiliative, aggressive, and self-defeating). There was a significant positive association between psychopathy, social exclusion, and aggressive styles of humor, and a negative association between psychopathy and affiliative styles of humor. Moreover, the results of a mediation analysis indicated that the association between psychopathy and aggressive humor style is completely explained by the experience of social exclusion. These results suggest that high psychopathic participants who are socially excluded use an aggressive humor style more often than low psychopathic individuals. The present study provides further insights into the role played by social environmental factors in the links between psychopathy and associated interpersonal characteristics. 相似文献