“Bridge to the Literature”? Third-Party Genetic Interpretation Tools and the Views of Tool Developers

Patients and health care consumers can obtain access to their “raw,” or uninterpreted, genetic data from direct-to-consumer genetic testing companies, researchers, or providers and pursue self-directed analysis via third-party interpretation tools. Yet relatively little is known about the nature of currently available interpretation tools or the motivations of tool developers. We conducted a structured content analysis of 23 third-party interpretation tool websites and supporting information, tracking features such as types of information returned, modes of generating and presenting that information, and privacy and security measures. We additionally conducted qualitative interviews with a subset of 10 tool developers. A majority of tools (16 of 23, or 70%) offer some type of health or wellness-related information, often extracted from publicly available variant annotation databases. Half of those interviewed characterized their activities as “bridging” users to the scientific literature rather than interpretation, for which they gave a variety of scientific, ethical, and regulatory justifications. The scale, heterogeneity, and complexity of information available from third-party interpretation are unprecedented. While developers aim to enlighten and empower tool users, interpretation-free “bridging” to rapidly evolving databases may instead impose burdens on genetic counselors and other health care providers asked to provide further contextualization and explanation.     

Handedness and Reach-to-Place Kinematics in Adults: Left-Handers Are Not Reversed Right-Handers

The primary goal of this study was to examine the relations between limb control and handedness in adults. Participants were categorized as left or right handed for analyses using the Edinburgh Handedness Inventory. Three-dimensional recordings were made of each arm on two reach-to-place tasks: adults reached to a ball and placed it into the opening of a toy (fitting task), or reached to a Cheerio inside a cup, which they placed on a designated mark after each trial (cup task). We hypothesized that limb control and handedness were related, and we predicted that we would observe side differences favoring the dominant limb based on the dynamic dominance hypothesis of motor lateralization. Specifically, we predicted that the dominant limb would be straighter and smoother on both tasks compared with the nondominant limb (i.e., right arm in right-handers and left arm in left-handers). Our results only partially supported these predictions for right-handers, but not for left-handers. When differences between hands were observed, the right hand was favored regardless of handedness group. Our findings suggest that left-handers are not reversed right-handers when compared on interlimb kinematics for reach-to-place tasks, and reaffirm that task selection is critical when evaluating manual asymmetries.     

Changes in schemas of patients with severe borderline personality disorder: The Oulu BPD study

Borderline personality disorder (BPD) is a relatively common and severe psychiatric disorder that can impair quality of life in many ways. The aim of this study was to determine whether a combined treatment model for BPD patients, utilising major principles from schema‐focused therapy (SFT) and dialectical behavioral therapy (DBT), could be more effective in relieving early maladaptive schemas of BPD patients, compared to treatment as usual (TAU). This study is a part of the Oulu BPD study conducted at mental health care services run by Oulu city social and health care services. The study is a multisite, randomized controlled trial conducted over a one year period, involving two groups of patients with severe BPD: (1) Community Treatment By Experts (CTBE) patients (n = 18) receiving the combined treatment model, and 2) TAU patients (n = 27). The patients' schemas were assessed using the Young Schema Questionnaire (YSQ‐L3a) before and after one year of treatment. The results reveal that CTBE patients who attended the combined treatment model showed a statistically significant reduction in eight out of 18 early maladaptive schemas, while patients receiving treatment as usual did not demonstrate any significant changes in schemas. The cognitive therapeutic treatment model can be applied for clinical use in public mental health settings using existing professionals, and appears to produce positive changes in patients with BPD.     

Cultural Competence and School Counselor Training: A Collective Case Study

This collective case study investigated the experiences of bilingual counselors‐in‐training who assessed school‐wide cultural competence in public schools. Analysis and interpretation of data resulted in the identification of 5 themes: eye‐opening experiences, recognition of strengths, the role of school leaders, road maps for change, and empowering marginalized groups. Implications and recommendations are discussed. Este estudio de caso colectivo investigó las experiencias de consejeros bilingües en formación que evaluaron la competencia cultural institucional en escuelas públicas. El análisis e interpretación de los datos dieron como resultado la identificación de 5 temas: experiencias reveladoras, reconocimiento de puntos fuertes, el papel de los líderes académicos, hojas de ruta para el cambio y empoderamiento de grupos marginalizados. Se discuten las implicaciones y recomendaciones.     

Augmenting Visual Search Performance With Transcranial Direct Current Stimulation (tDCS)

Military personnel endure rigorous and demanding man-hours designated to monitoring and locating targets in tasks such as cyber defense and Unmanned Aerial Vehicle (UAV) operators. These tasks are monotonous and repetitive, which can result in vigilance decrement. The objective of the study was to implement a form of noninvasive brain stimulation known as transcranial DC stimulation (tDCS) over the left frontal eye field (LFEF) region of the scalp to improve cognitive performance. The participants received anodal and cathodal stimulation of 2 mA for 30 min as well as placebo stimulation on 3 separate days while performing the task. The findings suggest that anodal and cathodal stimulation significantly improves detection accuracy. Also, a correlation was detected between percent of eye closure (PERCLOS) and blinking frequency in relation to stimulation condition. Our data suggest that tDCS over the LFEF would be a beneficial countermeasure to mitigate the vigilance decrement and improve visual search performance.     

Preparatory adjustment of cognitive control in the task switching paradigm

In this article, the authors investigate the assumption that preparation while switching between cognitive tasks is dynamically adjusted to the current task demands. Performance in high-shift blocks (75% shifts) was compared with performance in high-repetition blocks (75% repetitions). This probability information was given either at the beginning of a block (global condition) or by specific probability cues before every trial (local condition). The authors report strong preparation effects (activation of the probable task and inhibition of the improbable task) in high-shift blocks, especially when specific probability cues were provided. In high-repetition blocks, however, the preparation effects were less pronounced. The results support the assumption that preparation is dynamically adjusted to the expected task requirements.