Can Children with Autism Recover? If So, How?

Although Autism Spectrum Disorders (ASD) are generally assumed to be lifelong, we review evidence that between 3% and 25% of children reportedly lose their ASD diagnosis and enter the normal range of cognitive, adaptive and social skills. Predictors of recovery include relatively high intelligence, receptive language, verbal and motor imitation, and motor development, but not overall symptom severity. Earlier age of diagnosis and treatment, and a diagnosis of Pervasive Developmental Disorder-Not Otherwise Specified are also favorable signs. The presence of seizures, mental retardation and genetic syndromes are unfavorable signs, whereas head growth does not predict outcome. Controlled studies that report the most recovery came about after the use of behavioral techniques. Residual vulnerabilities affect higher-order communication and attention. Tics, depression and phobias are frequent residual co-morbidities after recovery. Possible mechanisms of recovery include: normalizing input by forcing attention outward or enriching the environment; promoting the reinforcement value of social stimuli; preventing interfering behaviors; mass practice of weak skills; reducing stress and stabilizing arousal. Improving nutrition and sleep quality is non-specifically beneficial.     

Ruminative self-focus and autobiographical memory

Many studies have shown a positive relationship between elevated dispositional self-focus and emotional disorder. Trapnell and Campbell (1999) proposed that this relationship was only true for ruminative forms of self-focus, reflective self-focus being associated with psychological health. The present study aimed: (1) to examine the replicability of Trapnell and Campbell's (1999) questionnaire-based differentiation of reflective and ruminative dispositional self-focus; (2) to see whether reflection and rumination could also be differentiated using measures of autobiographical memory; (3) to see whether such memory measures could elucidate mechanisms underlying different forms of dispositional self-focus. 130 volunteers retrieved autobiographical memories to neutral cue words and completed questionnaires. Questionnaires differentiated reflection and rumination: reflection correlated with openness to experience, whereas rumination correlated with neuroticism, replicating previous findings that it is specifically ruminative self-focus that is maladaptive. Memory measures also differentiated reflection and rumination: reflection was unrelated to the affective qualities of memories, whereas rumination correlated with measures of the happiness, unhappiness and at-oneness of memories. Dispositional ruminative self-focus, like neuroticism, was specifically related to increased accessibility of memories of events where individuals felt “not at all at-one with things”. This style of memory access could underpin dispositional ruminative self-focus, which is closely linked to neuroticism.     

Using the Diffusion Model to Explain Cognitive Deficits in Attention Deficit Hyperactivity Disorder

Slow, variable, and error-prone performance on speeded reaction time (RT) tasks has been well documented in childhood ADHD, but equally well documented is the context-dependent nature of those deficits, particularly with respect to event rate. As event rates increase (or, as the interstimulus intervals become shorter), RTs decrease, a pattern of performance that has long been interpreted as evidence that cognitive deficits in ADHD are a downstream consequence of a fundamental difficulty in the regulation of arousal to meet task demands. We test the extent to which this is a misinterpretation of the data that occurs when RT and accuracy are considered separately, as is common in neurocognitive research. In two samples of children aged 8–10 with (N?=?97; 33 girls) and without (N?=?39; 26 girls) ADHD, we used the diffusion model, an influential computational model of RT, to examine the effect of event rate on inhibitory control in a go-no-go task. Contrary to longstanding belief, we found that fast event rates slowed the rate at which children with ADHD accumulated evidence to make a decision to “no-go”, as indexed by drift rate. This in turn resulted in a higher proportion of failed inhibits, and occurred despite increased task engagement, as reflected by changes in the starting point of the decision process. Thus, although faster event rates increased task engagement among children with ADHD, the increased engagement was unable to counteract the concurrent slowing of processing speed to “no-go” decisions. Implications for theoretical models of ADHD and treatments are discussed.     

A Retrospective Examination of Child Protection Involvement Among Young Adults Accessing Homelessness Services

Childhood maltreatment is associated with a variety of young adult adversities including homelessness. This study used linked administrative records to develop a population‐level, epidemiological characterization of the child protection histories of young adults accessing homelessness services. The records of all 17‐ to 24‐year‐olds receiving homeless services between 2011 and 2014 in San Francisco County, California (n = 2241) were probabilistically linked to statewide child protective service (CPS) records. Findings document that 50.0% of young adults had been reported for maltreatment at least once during childhood, yet the prevalence of past CPS involvement varied across demographic and child welfare characteristics. Homeless female youth were significantly more likely to have a CPS history than male youth (58.1% vs. 41.5%). Nearly twice as many Black clients accessing homelessness services had a CPS history as did White clients (59.8% vs. 31.8%). Roughly half (47.3%) of those with a childhood history of reported maltreatment had been last reported for maltreatment in another California county. Targeting services that address past trauma and instability among homeless young adults may be justified given the prevalence of CPS history in this population.     

Virtual reality cue reactivity assessment in cigarette smokers.

Drug craving has purportedly been linked to relapse and to substance use. For over two decades, cue reactivity has been a viable method to assess craving and physiological reactions to drug stimuli. However, traditional cue reactivity has faced the following limitations: austere situations or stimuli, lack of complex cues, lack of standardization, and limited generalization outside of the lab setting. In order to improve cue methodologies, a virtual reality (VR) nicotine cue reactivity assessment system (VR-NCRAS) was developed and tested in a controlled experimental trial. Ten nicotine dependent smokers were exposed to VR smoking cues and VR neutral cues in a standardized, timed, computer controlled experiment. Subjective craving and physiological responses were recorded and compared across VR-NCRAS stimuli. Subjective cigarette craving increased significantly and corresponding physiological reactivity was observed in response to VR smoking cues. VR neutral cues did not result in subjective or physiological changes consistent with craving. Implications of these findings on substance abuse research and treatment are discussed.     

The relationship between non-symbolic multiplication and division in childhood

Children without formal education in addition and subtraction are able to perform multi-step operations over an approximate number of objects. Further, their performance improves when solving approximate (but not exact) addition and subtraction problems that allow for inversion as a shortcut (e.g., a?+?b???b?=?a). The current study examines children's ability to perform multi-step operations, and the potential for an inversion benefit, for the operations of approximate, non-symbolic multiplication and division. Children were trained to compute a multiplication and division scaling factor (*2 or /2, *4 or /4), and were then tested on problems that combined two of these factors in a way that either allowed for an inversion shortcut (e.g., 8*4/4) or did not (e.g., 8*4/2). Children's performance was significantly better than chance for all scaling factors during training, and they successfully computed the outcomes of the multi-step testing problems. They did not exhibit a performance benefit for problems with the a*b/b structure, suggesting that they did not draw upon inversion reasoning as a logical shortcut to help them solve the multi-step test problems.     

Adults’ number-line estimation strategies: Evidence from eye movements

Although the development of number-line estimation ability is well documented, little is known of the processes underlying successful estimators’ mappings of numerical information onto spatial representations during these tasks. We tracked adults’ eye movements during a number-line estimation task to investigate the processes underlying number-to-space translation, with three main results. First, eye movements were strongly related to the target number’s location, and early processing measures directly predicted later estimation performance. Second, fixations and estimates were influenced by the size of the first number presented, indicating that adults calibrate their estimates online. Third, adults’ number-line estimates demonstrated patterns of error consistent with the predictions of psychophysical models of proportion estimation, and eye movement data predicted the specific error patterns we observed. These results support proportion-based accounts of number-line estimation and suggest that adults’ translation of numerical information into spatial representations is a rapid, online process.     

Young children's haptic exploratory procedures

Adults vary their haptic exploratory behavior reliably with variation both in the sensory input and in the task goals. Little is known about the development of these connections between perceptual goals and exploratory behaviors. A total of 36 children ages 3, 4, and 5 years and 20 adults completed a haptic intramodal match-to-sample task. Participants were instructed to feel the shape, texture, rigidity, or weight of a sample object and then were asked to find which of three test objects matched the sample on that specific property. Hand movements were examined to determine whether children produced the same exploratory procedures while gathering perceptual information about each property as adults who searched for the same kind of information. Children demonstrated that they had good haptic abilities in two ways: They matched the sample objects on the specified perceptual dimension at near ceiling levels, and they produced the same hand movement patterns to find the same properties as adults.     

Development of approach and inhibition in the first year: parallel findings from motor behavior,temperament ratings and directional cardiac response

A group of 139 infants was observed at 6 and 12 months. Approach and inhibition were measured via latencies to touch low– and high–intensity objects, directional cardiac response to low– and high–intensity sounds and maternal ratings of positive and fearful emotionality. Inhibition showed considerable increases in all three domains from 6 to 12 months. Also reflecting increases in inhibitory processes, correlations between individual infants’ responses to low– and high–intensity sounds were significantly smaller at 12 than at 6 months. Limited cross–domain validity was obtained linking large cardiac decelerations, low latencies to reach for toys and high ratings of positive emotionality. These findings are consistent with previous reports documenting relatively greater gains in inhibition than approach during the second half of the first year. Modest cross–domain consistency indicates separate mechanisms may moderate approach and inhibition in the three different realms.