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991.
AX+, BX- discrimination learning in the fear-potentiated startle paradigm: possible relevance to inhibitory fear learning in extinction
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The neural mechanisms of fear suppression most commonly are studied through the use of extinction, a behavioral procedure in which a feared stimulus (i.e., one previously paired with shock) is nonreinforced repeatedly, leading to a reduction or elimination of the fear response. Although extinction is perhaps the most convenient index of fear inhibition, a great deal of behavioral work suggests that postextinction training conditioned stimuli are both excitatory and inhibitory, making it difficult to determine whether a neural manipulation affects inhibition, excitation, or some combination thereof. For this reason we sought to develop a behavioral procedure that would render a stimulus primarily inhibitory while at the same time avoiding some of the issues raised by the traditional conditioned inhibition paradigm, namely second-order conditioning, external inhibition, and configural learning. Using the fear-potentiated startle paradigm, we adapted an AX+, BX- training procedure in which stimuli A and X were presented simultaneously and paired with shock, and stimuli B and X were presented simultaneously in the absence of shock. In testing, high levels of fear-potentiated startle were seen in the presence of A and AX and much lower levels were seen in the presence of B and AB, as would be predicted if stimulus B were a conditioned inhibitor. We believe this method is a viable alternative to the traditional conditioned inhibition training procedure and will be useful for studying the neural mechanisms of fear inhibition. 相似文献
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993.
Norris et al. recently reported experimental evidence that listeners learn phoneme categories in response to lexical feedback. To reconcile these findings with their modular account of speech perception, the authors argue that top-down feedback can be used to support phoneme learning, but not to influence on-line phonemic processing. We suggest that these findings have broader implications than the authors assume, and we discuss potential challenges for integrating a modular theory with top-down learning. 相似文献
994.
Henderson GE Davis AM King NM 《The American journal of bioethics : AJOB》2004,4(3):50-2; discussion W32
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996.
The current study compared the effects of hand raising and response cards during a writing instruction class in a middle-school resource classroom with students who were learning English as their second language. Response cards increased the rate and accuracy of academic responding, increased weekly quiz scores, and had mixed effects on off-task behavior, but most students reported that they preferred hand raising. 相似文献
997.
5-HT1a receptor antagonists block perforant path-dentate LTP induced in novel, but not familiar, environments
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Sanberg CD Jones FL Do VH Dieguez D Derrick BE 《Learning & memory (Cold Spring Harbor, N.Y.)》2006,13(1):52-62
Numerous studies suggest roles for monoamines in modulating long-term potentiation (LTP). Previously, we reported that both induction and maintenance of perforant path-dentate gyrus LTP is enhanced when induced while animals explore novel environments. Here we investigate the contribution of serotonin and 5-HT1a receptors to the novelty-mediated enhancement of LTP. In freely moving animals, systemic administration of the selective 5-HT1a antagonist WAY-100635 (WAY) attenuated LTP in a dose-dependent manner when LTP was induced while animals explored novel cages. In contrast, LTP was completely unaffected by WAY when induced in familiar environments. LTP was also blocked in anesthetized animals by direct application of WAY to the dentate gyrus, but not to the median raphe nucleus (MRN), suggesting the effect of systemic WAY is mediated by a block of dentate 5-HT1a receptors. Paradoxically, systemic administration of the 5-HT1a agonist 8-OH-DPAT also attenuated LTP. This attenuation was mimicked in anesthetized animals following application of 8-OH-DPAT to the MRN, but not the dentate gyrus. In addition, application of a 5-HT1a agonist to the dentate gyrus reduced somatic GABAergic inhibition. Because serotonergic projections from the MRN terminate on dentate inhibitory interneurons, these data suggest 5-HT1a receptors contribute to LTP induction via inhibition of GABAergic interneurons. Moreover, activation of raphe 5-HT1a autoreceptors, which inhibits serotonin release, attenuated LTP induction even in familiar environments. This suggests that serotonin normally contributes to dentate LTP induction in a variety of behavioral states. Together, these data suggest that serotonin and dentate 5-HT1a receptors play a permissive role in dentate LTP induction, particularly in novel conditions, and presumably, during the encoding of novel, hippocampus-relevant information. 相似文献
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Ratings of age of acquisition (AoA), imageability, and familiarity were collected for 1,526 words. The methodology made use
of a modular approach, in which the full sample of words was divided into five separate blocks. Within each block, each word
was rated on each of the three variables by 20 participants (undergraduate students from the University of Bristol). Analyses
comparing these ratings to existing norm databases demonstrated that this methodology resulted in high reliability (assessed
by Cronbach’s α) and validity. The ratings were also transformed to be compatible with the Gilhooly and Logie (1980) norms.
This transformation resulted in a set of norms for 3,394 words, which is by far the largest database of ratings for AoA, imageability,
and familiarity to date. The resulting database should be useful for researchers interested in manipulating or controlling
these factors in word recognition, neuropsychological, or memory studies. These norms can be downloaded from language.psy.bris
.ac.uk/bristol_norms.html. 相似文献