Dynamic shifts in corticostriatal expression patterns of the immediate early genes Homer 1a and Zif268 during early and late phases of instrumental training

Adaptive motor actions require prior knowledge of instrumental contingencies. With practice, these actions can become highly automatic in nature. However, the molecular and anatomical substrates mediating these related forms of learning are not understood. In the present study, we used in situ hybridization to measure the mRNA levels of two immediate early genes (IEGs) in an instrumental paradigm where rats learned to lever-press for food. We report that after three training sessions, Homer 1a and Zif268 (an effector and regulatory IEG, respectively) were significantly induced within an extensive corticostriatal network relative to untrained controls. With extended training (23 sessions), however, a shift in the expression patterns of the two genes was evident. Expression of Homer 1a (official symbol Homer1) decreased significantly in frontal and cingulate cortices, whereas striatal expression was generally maintained. Interestingly, Homer 1a expression markedly increased with extensive training in the ventrolateral region of the striatum (VLS) relative to early learners, suggesting that plasticity in the VLS is required for the efficient production of the learned behavior or in habit formation. Zif268 (official symbol Egr1) expression generally decreased with extensive training; however, these changes were not significant. These results demonstrate for the first time, on a molecular level, a dynamic shift in the contribution of corticostriatal systems mediating the early acquisition and consolidation of goal-directed responses to those engaged after extensive training.     

Principles of Religious Prosociality: A Review and Reformulation

Historically, religion and religious belief have often been credited as the source of human morality. But what have been the real effects of religion on prosocial behavior? A review of the psychological literature reveals a complex relation between religious belief and moral action: leading to greater prosocial behavior in some contexts but not in others, and in some cases actually increasing antisocial behavior. In addition, different forms of religious belief are associated with different styles of co-operation. This body of evidence paints a somewhat messy picture of religious prosociality; however, recent examinations of the cognitive mechanisms of belief help to resolve apparent inconsistencies. In this article, we review evidence of two separate sources of religious prosociality: a religious principle associated with the protection of the religious group, and a supernatural principle associated with the belief in God, or other supernatural agents. These two principles emphasize different prosocial goals, and so have different effects on prosocial behavior depending on the target and context. A re-examination of the literature illustrates the independent influences of religious and supernatural principles on moral action.     

The emergence of competing modules in bilingualism

How does the brain manage to store and process multiple languages without encountering massive interference and transfer? Unless we believe that bilinguals live in two totally unconnected cognitive worlds, we would expect far more transfer than actually occurs. However, imaging and lesion studies have not provided consistent evidence for the strict neuronal separation predicted by the theory of modularity. We suggest that emergentist theory offers a promising alternative. It emphasizes the competitive interplay between multiple languages during childhood and by focusing on the dual action of competition and entrenchment, avoids the need to invoke a critical period to account for age of acquisition effects in second-language learning. This view instantiates the motto formulated by Elizabeth Bates that 'modules are made, not born.'     

Interethnic Relations on Campus: Can't We All Get Along?

This study examined the ethnic climate and relationships between ethnic groups at 5 colleges. Data indicate that White and Latino students were the most comfortable interacting with other ethnic groups, whereas Asians students were the least comfortable. Furthermore, White students had a relatively positive view of the interracial climate in contrast to Black students who described their campuses as more hostile and uninviting.     

Men and women holding hands: II. Whose hand is uppermost?

Sex differences in the way men and women hold hands were investigated in a series of six studies. Specifically, it was hypothesized that men would have the uppermost hand in male-female couples holding hands in public significantly more often than women. Also, the American couples observed in Study 1 were classified by height, those in Study 2 by age, those in Study 3 by hand preference, those in Study 4 by ethnic group, and those in Study 6 by sex of initiator of the handholding; the handholding couples in Study 5 were Japanese adults. A combined total of 15,008 handholding couples were observed in these six studies, and across differences in height, age, hand preference, ethnicity, culture, and sex of the initiator of handholding in public, men were significantly more likely than women to have the uppermost hand.     

Bilingual Performance on the Boston Naming Test: Preliminary Norms in Spanish and English

A total of 100 young educated bilingual adults were administered the Boston Naming Test (BNT) (Kaplan, Goodglass, & Weintraub, 1983) in both Spanish and English. Three group performance scores were obtained: English only, Spanish only, and a composite score indicating the total number of items correctly named independent of language. The scores for the entire group were significantly greater in English than in Spanish. An additional set of analyses explored individual differences in picture naming performance across the two languages as measured by the BNT. For a subset of the larger group (n= 25) there were significant differences in composite over single language scoring, but no significant differences between Spanish and English. Item analyses of correct responses were conducted in both languages to explore the construct validity of the standardized administration of the BNT with this population. There was much greater variability in responses over the Spanish items for this bilingual group. The results of a correlation analysis of information obtained from the initial questionnaire with the BNT scores in each language is also reported. The practical implications of this preliminary bilingual BNT normative data are discussed.     

Emotional and cognitive health correlates of leisure activities in older Latino and Caucasian women

This study examined differences in the frequency of leisure activity participation and relationships to depressive symptom burden and cognition in Latino and Caucasian women. Cross-sectional data were obtained from a demographically matched subsample of Latino and Caucasian (n?=?113 each) postmenopausal women (age ≥60 years), interviewed in 2004-2006 for a multiethnic cohort study of successful aging in San Diego County. Frequencies of engagement in 16 leisure activities and associations between objective cognitive performance and depressive symptom burden by ethnicity were identified using bivariate and linear regression, adjusted for physical functioning and demographic covariates. Compared to Caucasian women, Latinas were significantly more likely to be caregivers and used computers less often. Engaging in organized social activity was associated with fewer depressive symptoms in both groups. Listening to the radio was positively correlated with lower depressive symptom burden for Latinas and better cognitive functioning in Caucasians. Cognitive functioning was better in Latinas who read and did puzzles. Housework was negatively associated with Latinas' emotional health and Caucasians' cognitive functioning. Latino and Caucasian women participate in different patterns of leisure activities. Additionally, ethnicity significantly affects the relationship between leisure activities and both emotional and cognitive health.     

Individually tailored internet-based cognitive behaviour therapy for older adults with anxiety and depression: a randomised controlled trial

Mixed anxiety and depression is common among older adults. The aim of the study was to compare the effects of an eight-week-long tailored internet-supported cognitive behaviour therapy (ICBT) programme and to compare against the provision of weekly general support. A second aim was to investigate if pre-treatment cognitive flexibility and self-reported cognitive problems would predict outcome. We included 66 older adults (aged over 60 years) with mixed anxiety/depression following media recruitment and randomised them into treatment and control groups. We also included a one-year follow-up. As a measure of executive function, we used the Wisconsin Card Sorting Test (perseverative errors) and the Cognitive Failures Questionnaire during the pre-treatment phase. Results showed a moderate between-group effect on the main outcome measure, the Beck Anxiety Inventory (BAI) (d= .50), favouring the treatment group. Nearly half (45.5%) of that group were classified as responders. One person (3%) in the treatment group deteriorated. There were significant correlations between perseverative errors and outcome (on the BAI r = ?.45), but not among self-reported cognitive function. We conclude that guided, tailored ICBT may be effective for some older adults and that the role of cognitive function needs to be investigated further.     

The Integrity Objection,Reloaded

Abstract

Bernard Williams’ integrity objection poses a significant challenge to utilitarianism, which has largely been answered by utilitarians. This paper recasts the integrity objection to show that utilitarian agents could be committed to producing the overall best states of affairs and yet not positively act to bring them about. I introduce the ‘Moral Pinch Hitter’ – someone who performs actions at the bequest of another agent – to demonstrate that utilitarianism cannot distinguish between cases in which an agent maximizes utility by positively acting in response to her duty, and cases in which an agent fails morally by relying upon someone else to perform the obligatory act. The inability to distinguish among these cases establishes a new, reloaded integrity objection to utilitarianism: utilitarianism cannot explain why it would be wrong to have someone else make difficult moral decisions, and to act on those decisions, for me.