Contextual learning of multiple target locations in visual search

In visual search, detection of a target is faster when a layout of nontarget items is repeatedly encountered, suggesting that contextual invariances can guide attention. Moreover, contextual cueing can also adapt to environmental changes. For instance, when the target undergoes a predictable (i.e., learnable) location change, then contextual cueing remains effective even after the change, suggesting that a learned context is “remapped” and adjusted to novel requirements. Here, we explored the stability of contextual remapping: Four experiments demonstrated that target location changes are only effectively remapped when both the initial and the future target positions remain predictable across the entire experiment. Otherwise, contextual remapping fails. In sum, this pattern of results suggests that multiple, predictable target locations can be associated with a given repeated context, allowing the flexible adaptation of previously learned contingencies to novel task demands.     

Automatic priming for translation- and scale-invariant representations of object shape

A series of visual search experiments explored whether early visual processes are sensitive to the overall shape of objects. Previous work (Wolfe & Bennett, 1997) has suggested that information concerning overall shape is not coded in early vision. However, in Experiment 1, we demonstrate that these previous findings are explicable in terms of non-target heterogeneity rather than an absence of shape information in early vision. In Experiments 2 and 3, we demonstrate that shape similarity, rather than individual contour similarity, can determine search efficiency. In Experiments 4 and 5, we show that manipulating the contrast polarity of contours and defining shape using texture significantly impeded search for an odd-one-out shape. The implications of these results for shape processing in early vision are discussed.     

Effects of stimulus synchrony on mechanisms of perceptual organization

When neurons adopt a synchronized, oscillatory response to stimulus Gestalten, the phase of those oscillations almost always varies relative to stimulus activity. This has been taken to indicate that form-coding mechanisms are synchronized by internal timing mechanisms, and/or may be sensitive to stimulus activity only via motion detectors. This proposal is problematic for interpreting recent demonstrations of the effects of stimulus synchrony particularly when stimuli are stationary. Here we offer an account of stimulus-driven synchronization supported by evidence that segmentation by stimulus synchrony can be relatively insensitive to explicit motion signals. The argument is made that qualitative similarities between the effects of phase-independent and phase-locked oscillations in the EEG, the effects of phase synchronization at the cellular level and evidence for phase-enhanced stimulus grouping should be considered as functionally equivalent. This argument emphasizes the flexibility of temporal synchrony as a code for perceptual organization.     

The scenic function of the ego and its role in symptom and character formation1

The author argues that the scenic function of the ego permits the situationally appropriate representation of an unconscious, infantile configuration – that is, of a relatively stable, personality‐based drive scene having the same status as latent dream thoughts. The products of conflict elaboration (symptoms, etc.) are manifested in different ways in accordance with the conditions of the relevant situation. The contents of the drive scene are created by the psychical apparatus on the basis of infantile perceptions and are revealed in screen memories. The capacity for situationally appropriate representation is apparently bound up with the mobile drive, including its narcissistic transformations. Desexualization (in the sense of neutralization) renders scenic elaboration impossible. The drive derivatives withdrawn from the scenic configuration contribute to ego organization and the formation of character traits, which no longer vary according to the situation, but can only be modified by a change in personality structure itself. It is as yet unclear whether a process of resexualization can make them amenable once more to analytic work. The form of narcissistic libido that can assume a scenic configuration is closely related to primary narcissism. Its manifestations, which may likewise emerge in situation‐dependent symptom formations, appear accessible to analysis.     

CB1 cannabinoid receptors modulate kinase and phosphatase activity during extinction of conditioned fear in mice

Cannabinoid receptors type 1 (CB1) play a central role in both short-term and long-term extinction of auditory-cued fear memory. The molecular mechanisms underlying this function remain to be clarified. Several studies indicated extracellular signal-regulated kinases (ERKs), the phosphatidylinositol 3-kinase with its downstream effector AKT, and the phosphatase calcineurin as potential molecular substrates of extinction behavior. To test the involvement of these kinase and phosphatase activities in CB1-dependent extinction of conditioned fear behavior, conditioned CB1-deficient mice (CB1(-/-)) and wild-type littermates (CB1(+/+)) were sacrificed 30 min after recall of fear memory, and activation of ERKs, AKT, and calcineurin was examined by Western blot analysis in different brain regions. As compared with CB1(+/+), the nonreinforced tone presentation 24 h after auditory-cued fear conditioning led to lower levels of phosphorylated ERKs and/or calcineurin in the basolateral amygdala complex, ventromedial prefrontal cortex, dorsal hippocampus, and ventral hippocampus of CB1(-/-). In contrast, higher levels of phosphorylated p44 ERK and calcineurin were observed in the central nucleus of the amygdala of CB1(-/-). Phosphorylation of AKT was more pronounced in the basolateral amygdala complex and the dorsal hippocampus of CB1(-/-). We propose that the endogenous cannabinoid system modulates extinction of aversive memories, at least in part via regulation of the activity of kinases and phosphatases in a brain structure-dependent manner.     

Neuropsychology and temporal lobe epilepsy

The purpose of this article is to review aspects of the neuropsychology of temporal lobe epilepsy. Evidence will be presented to demonstrate that the cognitive consequences of this focal seizure disorder can be more generalized in nature than expected. Consistent with the extratemporal neurocognitive findings, careful quantitative magnetic resonance imaging volumetrics have shown that structural brain changes may be detected outside the temporal lobes. Many factors can potentially affect cognition and brain structure. We focus on the potential neurodevelopmental impact of early-onset temporal lobe epilepsy on brain structure and cognition positing that this disorder can have both immediate and lifespan implications for cognition and psychosocial status.     

Temporal lobe epilepsy and the selective reminding test: the conventional 30-minute delay suffices

Conventional memory assessment may fail to identify memory dysfunction characterized by intact recall for a relatively brief period but rapid forgetting thereafter. This study assessed learning and retention after 30-min and 24-hr delays on auditory and visual selective reminding tests (SRTs) in right (n=20) and left (n=22) temporal lobe epilepsy (TLE) patients and controls (n=49). The left TLE group performed significantly worse than controls on all 3 trials of both tests. The right TLE group differed from the controls on all 3 visual SRT trials and on learning for the auditory SRT. There were no between-groups differences in rate of information lost at the 30-min versus the 24-hr delay. At the individual level, there was no difference in the percentage of patients versus controls who demonstrated isolated memory impairment at the 24-hr delay. Accelerated forgetting over 24 hr is uncommon in TLE patients.     

Criminal defenses and pleas in mitigation based on amnesia

Criminal defendants often claim to suffer from amnesia in connection with the events that are the basis of the criminal charges made against them. These claims present difficult problems of proof. Moreover, there are various defenses and opportunities to make pleas in mitigation which present a number of contexts in which evidence of amnesia can be introduced into the criminal trial. This article will examine the significance of amnesia in relation to: (1) a defense based on lack of mens rea; (2) a defense based on diminished capacity; (3) the insanity defense; (4) lack of fitness to stand trial; and (5) sentencing and the death penalty.     

Attentional localization prior to simpleand directed manual responses

The relationship between attention and the programming of motor responses was investigated, using a paradigm in which the onsets of targets for movements were preceded by peripheral attentional cues. Simple (button release) and reaching manual responses were compared under conditions in which the subjects either made saccades toward the target location or refrained from making eye movements. The timing of the movement onset was used as the dependent measure for both simple and reaching manual responses. Eye movement latencies were also measured. A follow-up experiment measured the effect of the same peripheral cuing procedure on purely visual processes, using signal detection mea-sures of visual sensitivity and response bias. The results of the first experiment showed that reaction time (RT) increased with the distance between the cued and the target locations. Stronger distance ef-fects were observed when goal-directed responses were required, which suggests enhanced attentional localization of target positions under these conditions. The requirement to generate an eye movement response was found to delay simple manual RTs. However, mean reaching RTs were unaffected by the eye movement condition. Distance gradients on eye movement latencies were relatively shallow, as compared with those on goal-directed manual responses. The second experiment showed that the peripheral cue had only a very small effect on visual detection sensitivity in the absence of directed motor responses. It is concluded that cue-target distance effects with peripheral cues are modulated by the motor-programming requirements of the task. The effect of the peripheral cue on eye movement latencies was qualitatively different from that observed on manual RTs, indicating the existence of separate neural representations underlying both response types. At the same time, the interactions be-tween response modalities are consistent with a supramodal representation of attentional space, within which different motor programs may interact.     

Searching for impossible objects: Processing form and attributes in early vision

In five experiments, we investigated the extent to which form (shape) and metric attributes (three-dimensional, 3-D, orientation), both defined by relations between une elements, are processed in early vision. Search for a target defined by an abstract property of form (i.e., impossibility) was slow and serial. In contrast, search for a 3-D orientation target was considerably easier. Subsequent experiments suggest that this difference reflects the fact that 3-D orientation is derivable from localized sets of lines, whereas impossibility is an idiosyncratic property of the complete set of relations between lines. We conclude that only “gross” aspects of form are available in early vision as the complete set of line relations is not processed preattentively. However, localized processing of line relations is sufficient to derive 3-D orientation.