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361.
Palatable food intake reduces stress responses, suggesting that individuals may consume such ?comfort? food as self-medication for stress relief. The mechanism by which palatable foods provide stress relief is not known, but likely lies at the intersection of forebrain reward and stress regulatory circuits. Forebrain opioidergic and gamma-aminobutyric acid ergic signaling is critical for both reward and stress regulation, suggesting that these systems are prime candidates for mediating stress relief by palatable foods. Thus, the present study (1) determines how palatable ?comfort? food alters stress-induced changes in the mRNA expression of inhibitory neurotransmitters in reward and stress neurocircuitry and (2) identifies candidate brain regions that may underlie comfort food-mediated stress reduction. We used a model of palatable ?snacking? in combination with a model of chronic variable stress followed by in situ hybridization to determine forebrain levels of pro-opioid and glutamic acid decarboxylase (GAD) mRNA. The data identify regions within the extended amygdala, striatum, and hypothalamus as potential regions for mediating hypothalamic-pituitary-adrenal axis buffering following palatable snacking. Specifically, palatable snacking alone decreased pro-enkephalin-A (ENK) mRNA expression in the anterior bed nucleus of the stria terminalis (BST) and the nucleus accumbens, and decreased GAD65 mRNA in the posterior BST. Chronic stress alone increased ENK mRNA in the hypothalamus, nucleus accumbens, amygdala, and hippocampus; increased dynorphin mRNA in the nucleus accumbens; increased GAD65 mRNA in the anterior hypothalamus and BST; and decreased GAD65 mRNA in the dorsal hypothalamus. Importantly, palatable food intake prevented stress-induced gene expression changes in subregions of the hypothalamus, BST, and nucleus accumbens. Overall, these data suggest that complex interactions exist between brain reward and stress pathways and that palatable snacking can mitigate many of the neurochemical alterations induced by chronic stress. 相似文献
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Posthumus JA Raaijmakers MA Maassen GH van Engeland H Matthys W 《Journal of abnormal child psychology》2012,40(4):487-500
The present study evaluated preventive effects of the Incredible Years program for parents of preschool children who were
at risk for a chronic pattern of conduct problems, in the Netherlands. In a matched control design, 72 parents of children
with conduct problems received the Incredible Years program. These families (intervention group) were compared with 72 families
who received care as usual (control group). Two years after termination of the intervention, it appeared that observed and
selfrated parenting skills were significantly improved in the intervention group. Likewise, in this group, observed child
conduct problems showed sustained intervention effects. The decrease in observed critical parenting mediated the decrease
in observed child conduct problems over time. In addition, it appeared that parental influence increased over time. 相似文献
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Sarah E. Stutterheim Arjan E. R. Bos Nicole M. C. van Kesteren Iris Shiripinda John B. Pryor Marijn de Bruin Herman P. Schaalma 《Journal of community & applied social psychology》2012,22(6):470-484
Thirty years after the first diagnosis, people living with HIV (PLWH) around the world continue to report stigmatizing experiences. In this study, beliefs contributing to HIV‐related stigma in African and Afro‐Caribbean diaspora communities and their cultural context were explored through semi‐structured interviews with HIV‐positive (N = 42) and HIV‐negative (N = 52) African, Antillean and Surinamese diaspora community members in the Netherlands. Beliefs that HIV is highly contagious, that HIV is a very severe disease, and that PLWH are personally responsible for acquiring their HIV infection were found to contribute to HIV‐related stigma, as did the belief that PLWH are HIV‐positive because they engaged in norm‐violating behaviour such as promiscuity, commercial sex work, and, for Afro‐Caribbean diaspora, also homosexuality. These beliefs were found to be exacerbated and perpetuated by cultural taboos on talking about HIV and sexuality. HIV‐related stigma reduction interventions should focus on changing these beliefs and breaking cultural taboos on HIV and sexuality in a manner that is participatory and consistent with the current theory and empirical findings. Copyright © 2011 John Wiley & Sons, Ltd. 相似文献
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Jonathan R. Herman 《Teaching Theology & Religion》2019,22(4):293-294
One of three short companion essays to Terry Shoemaker's “World Religion and Fake News: A Pedagogical Response in an Age of Post‐Truth,” published in this issue of the journal. 相似文献