Auditory physiology and behavior in RB/1bg, RB/3bg, and their F1 hybrid mice (Mus musculus): influence of genetics, age, and acoustic variables on audiogenic seizure thresholds and cochlear functions

In the early 1950s, Frings and Frings began a process of selection for audiogenic seizure susceptibility and resistance in albino mice. The present study was conducted to examine behavioral and cochlear functions in the inbred descendants of these mice. The cochlear action potential (AP) thresholds of the susceptible RB/1bg inbred mice were abnormally high, and the resistant inbred RB/3bg mice had normal AP audiograms. The F1 hybrid showed heterosis for its cochlear function. Only the RB/1bg was susceptible to audiogenic seizures on the first acoustic exposure. Thresholds for the successive components of their audiogenic seizures were determined in response to narrow bands of noise. These paralleled the AP thresholds of RB/1bg mice (r = .89). This RB/1bg mouse showed little age-related cochlear loss, which probably accounts for its robust sensitivity to audiogenic seizures over most of its lifespan. Earlier studies had demonstrated that the susceptible RB line had a robust AP, but little or no cochlear microphonic (CM). The susceptible RB/1bg had well-defined AP and CM responses at low frequencies. The nonsusceptible RB/3bg mice were more resistant to acoustic priming than another mouse (CBA/J) strain with a similar audiometric profile.     

Social interaction patterns of geriatric home and community residents

Thirty elderly nursing home residents and ten community residing older adults were observed in group settings. Their behavior was assessed for dependent personal maintenance, independent personal maintenance, and appropriate and inappropriate behaviors. Responses by staff and peers to these behaviors were classified as positive, negative, or ignore. The frequency of occurrence of these behaviors as well as the relationship of resident to peer or staff behaviors were analyzed. Results indicate that community-residing elders' behaviors differ from nursing home residents' in quantity rather than quality of interactions. There was a lower frequency of behaviors in the nursing home residents. Though older adults respond differentially to various behaviors of other nursing home residents, staff responses were consistent regardless of residents' behavior. These results suggest that geriatric home residents' behavior can be characterized as withdrawn rather than dependent.     

Biological basis of the stress response.

Chronic, as well as acute emotional arousal, is a consequence of various types of social interaction, i.e., those between mother and infant and between controlling dominant and less effective subordinate. The neurohumoral accompaniments of this social stress include the sympathetic adrenal medullary and hypothalamic pituitary adrenal responses. A common ensuing pathophysiological state involves a chronic increase of blood pressure. Although Selye's General Adaptation Syndrome presupposed the same response to a variety of stimuli; recent work shows that specific perceptions of control result in different patterns of neuroendocrine activation. A challenge perceived as easy to handle will elicit an active coping response and release of the neurosympathetic system's norepinephrine. Testosterone will rise as the subject savors success. With increasing anxiety this active coping shifts to a more passive mode and the behavior becomes less assured as the animal loses control. The norepinephrine/epinephrine ratio decreases as epinephrine, prolactin, renin and fatty acids rise. As the outcome becomes still less certain and distress grows, adrenocorticotropic hormone and cortisol levels arise. Thus, the effort required on the one hand and the degree of frustration conflict and uncertainty on the other, determine the ratio of catecholamines to corticoids. With severe emotional trauma, brain dysfunction may occur. These effects can be lasting, and corticoids paradoxically return to normal as the behavior changes to that of post-traumatic stress disorder. Repression and denial set in and the organism responds with decreased concern of impaired attachment and increased irritability.     

Biological basis of the stress response

Chronic, as well as acute emotional arousal, is a consequence of various types of social interaction, i.e., those between mother and infant and between controlling dominant and less effective subordinate. The neurohumoral accompaniments of this social stress include the sympathetic adrenal medullary and hypothalamic pituitary adrenal responses. A common ensuing pathophysiological state involves a chronic increase of blood pressure. Although Selye’s General Adaptation Syndrome presupposed the same response to a variety of stimuli; recent work shows that specific perceptions of control result in different patterns of neuroendocrine activation. A challenge perceived as easy to handle will elicit an active coping response and release of the neurosympathetic system’s norepinephrine. Testosterone will rise as the subject savors success. With increasing anxiety this active coping shifts to a more passive mode and the behavior becomes less assured as the animal loses control. The norepinephrine/epinephrine ratio decreases as epinephrine, prolactin, renin and fatty acids rise. As the outcome becomes still less certain and distress grows, adrenocorticotropic hormone and cortisol levels arise. Thus, the effort required on the one hand and the degree of frustration conflict and uncertainty on the other, determine the ratio of catecholamines to corticoids. With severe emotional trauma, brain dysfunction may occur. These effects can be lasting, and corticoids paradoxically return to normal as the behavior changes to that of post-traumatic stress disorder. Repression and denial set in and the organism responds with decreased concern of impaired attachment and increased irritability.     

A new method of monitoring motor activity in baboons

Movement activity of a normal baboon and of a baboon with induced Parkinsonism by unilateral administration of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) was recorded by the Walter Reed Activity Monitor (or actigraph). Mean activity in the lesioned baboon was 41% less than that of the nonlesioned baboon measured over a 14-day period. In addition, the daily maximum activity value was significantly less in the MPTP-treated baboon. Moreover, resting and sleeping periods were 30% greater in the lesioned animal. The akinesia and resting and sleeping periods were displayed by the lesioned baboon throughout the day, whereas the control baboon showed them only at night. The data representing summarized movement activity are in accordance with observations of bradykinesia, hypokinesia, and akinesia of the MPTP-treated baboon. The actigraph was well tolerated by the animal because its small size and weight made it largely unobtrusive. We suggest that the actigraph is an appropriate device for measuring motor activity in nonhuman primates.     

Two approaches to the formalisation of defeasible deontic reasoning

This paper compares two ways of formalising defeasible deontic reasoning, both based on the view that the issues of conflicting obligations and moral dilemmas should be dealt with from the perspective of nonmonotonic reasoning. The first way is developing a special nonmonotonic logic for deontic statements. This method turns out to have some limitations, for which reason another approach is recommended, viz. combining an already existing nonmonotonic logic with a deontic logic. As an example of this method the language of Reiter's default logic is extended to include modal expressions, after which the argumentation framework in default logic of [20, 22] is used to give a plausible logical analysis of moral dilemmas and prima facie obligations.An earlier version of this article was written while the author was working at the Department of Computing, Imperial College London, supported by ESRC/MRC/SERC Joint Council Initiative Project G9212036. Work on the present version was supported by a research fellowship of the Royal Netherlands Academy of Arts and Sciences, and by Esprit WG 8319 Modelage. I thank one of the referees for his interesting comments. Also, many thanks are due to Marek Sergot for valuable discussions on the topic of this paper.     

Helping Groups Determine Their Most Accurate Member: The Role of Outcome Feedback1

One of the difficulties groups have when making quantitative judgments is determining the relative quality of members’ inputs. Outcome feedback was investigated as a method for improving the ability of groups to identify their most accurate member. Results indicate that groups given outcome feedback were better at identifying their best member than were groups that practiced without feedback. This occurred even though the same individual was seldom the most accurate across items. However, groups given feedback were not as accurate as their best member any more often. This suggests that groups given feedback are learning how to discriminate valid from invalid cues, but are not using this information consistently when making their group estimates.     

The development and validation of computer self-efficacy and outcome expectancy scales in a nonvolitional context

Computer self-efficacy and outcome expectancy scales were developed using 306 responses to a questionnaire distributed by a national mail survey to end users of computer systems in a variety of functional business areas. Confirmatory factor analysis using a structural equations approach was used to develop three scales. The scales were found to demonstrate satisfactory psychometric properties. The reliability coefficients for these scales were as follows: .85 for computer self-efficacy; .88 for work-related outcome expectancy; and .89 for personal outcome expectancy. The scales provide a strong foundation from which to refine the measurement of computer self-efficacy and outcome expectancy. From these refinements, empirical models that include self-efficacy and outcome expectancy as determinants of information technology acceptance at the individual level of analysis can be improved.