When feature information comes first! Early processing of inverted faces

We investigated the early stages of face recognition and the role of featural and holistic face information. We exploited the fact that, on inversion, the alienating disorientation of the eyes and mouth in thatcherised faces is hardly detectable. This effect allows featural and holistic information to be dissociated and was used to test specific face-processing hypotheses. In inverted thatcherised faces, the cardinal features are already correctly oriented, whereas in undistorted faces, the whole Gestalt is coherent but all information is disoriented. Experiment 1 and experiment 3 revealed that, for inverted faces, featural information processing precedes holistic information. Moreover, the processing of contextual information is necessary to process local featural information within a short presentation time (26 ms). Furthermore, for upright faces, holistic information seems to be available faster than for inverted faces (experiment 2). These differences in processing inverted and upright faces presumably cause the differential importance of featural and holistic information for inverted and upright faces.     

The Wall inside the brain: Overestimation of distances crossing the former Iron Curtain

A study of distance estimations between German cities investigated the organization of mental maps and their specific deviations from reality. Potential factors for the deviation of mental maps from reality are physical barriers, emotional involvement, and semantic unity. Distance estimations between cities situated in different former parts of Germany (East or West) were systematically overestimated compared to distances of cities located in the same parts of Germany. This trend was strengthened when participants had a negative attitude toward the reunification of Germany. The impact of these results is far reaching, because overestimated distances between both German parts indicate that there still exists a mental gap between East and West—even in young people—15 years after the German reunification.     

Histidine-decarboxylase knockout mice show deficient nonreinforced episodic object memory, improved negatively reinforced water-maze performance, and increased neo- and ventro-striatal dopamine turnover

The brain's histaminergic system has been implicated in hippocampal synaptic plasticity, learning, and memory, as well as brain reward and reinforcement. Our past pharmacological and lesion studies indicated that the brain's histamine system exerts inhibitory effects on the brain's reinforcement respective reward system reciprocal to mesolimbic dopamine systems, thereby modulating learning and memory performance. Given the close functional relationship between brain reinforcement and memory processes, the total disruption of brain histamine synthesis via genetic disruption of its synthesizing enzyme, histidine decarboxylase (HDC), in the mouse might have differential effects on learning dependent on the task-inherent reinforcement contingencies. Here, we investigated the effects of an HDC gene disruption in the mouse in a nonreinforced object exploration task and a negatively reinforced water-maze task as well as on neo- and ventro-striatal dopamine systems known to be involved in brain reward and reinforcement. Histidine decarboxylase knockout (HDC-KO) mice had higher dihydrophenylacetic acid concentrations and a higher dihydrophenylacetic acid/dopamine ratio in the neostriatum. In the ventral striatum, dihydrophenylacetic acid/dopamine and 3-methoxytyramine/dopamine ratios were higher in HDC-KO mice. Furthermore, the HDC-KO mice showed improved water-maze performance during both hidden and cued platform tasks, but deficient object discrimination based on temporal relationships. Our data imply that disruption of brain histamine synthesis can have both memory promoting and suppressive effects via distinct and independent mechanisms and further indicate that these opposed effects are related to the task-inherent reinforcement contingencies.     

Monotone Majorizable Functionals

Several properties of monotone functionals (MF) and monotone majorizable functionals (MMF) used in the earlier work by the author and van de Pol are proved. It turns out that the terms of the simply typed lambda-calculus define MF, but adding primitive recursion, and even monotonic primitive recursion changes the situation: already Z.Z(1 — sg) is not MMF. It is proved that extensionality is not Dialectica-realizable by MMF, and a simple example of a MF which is not hereditarily majorizable is given.     

Anti-NMDA-Rezeptor-Enzephalitis

Die Anti-NMDA(N-Methyl-D-Aspartat)-Rezeptor-Enzephalitis ist eine seltene autoimmunologisch bedingte Erkrankung mit verschiedenen neuropsychiatrischen Symptomen, die durch den Nachweis von NMDA-Rezeptor-Antikörpern im Liquor diagnostiziert wird. Die gängigen Behandlungsprotokolle beinhalten ein Stufenschema der Immuntherapien; allerdings beruhen die therapeutischen Entscheidungen derzeit auf einem Grad-IV-Evidenzniveau. Wir berichten hier über zwei junge, unterschiedlich betroffene Patientinnen und beschreiben die Therapiestrategien inklusive der Kombination verschiedener Immuntherapien einschließlich Ocrelizumab und Überlegungen bezüglich Fertilitätserhalt.     

When inverted faces are recognized: The role of configural information in face recognition

The identification of upright faces seems to involve a special sensitivity to "configural" information, the processing of which is less effective when the face is inverted. However the precise meaning of "configural" remains unclear. Five experiments are presented, which showed that the disruption of the processing of relational, rather than holistic, information largely determines the occurrence as well as the size of the face-inversion effect. In Experiment 1, faces could be identified either by unique combinations of local information (e.g. a specific eye colour plus hair colour) or by unique relational information (e.g. nose-mouth distance). The former showed no inversion effect, whereas the latter did. A combination of local and relational information (Experiment 2) again produced an inversion effect, although this effect was smaller than that found when only relational information was used. The results were replicated in Experiment 3 when differences in the brightness of local features were used instead of specific colour combinations. Experiment 4 used different retrieval conditions to distinguish relational from holistic processing, and demonstrated again that spatial relations between single features appeared to provide crucial information for face recognition. In Experiment 5, the importance of relational information was confirmed using faces that also varied in the shapes of local features.     

Context effects on emotional and aesthetic evaluations of artworks and IAPS pictures

In the arts emotionally negative objects sometimes can be positively judged. Defining an object as art possibly yields specific changes in how perceivers emotionally experience and aesthetically judge a stimulus. To study how emotional experiences (joy, anger, disgust, fear, sadness, and shame ratings, plus facial EMG) and aesthetic judgements (liking ratings) are modulated by an art context (“This is an artwork”) as compared to non-art reality context (“This is a press photograph”) participants evaluated IAPS pictures and veridical artworks depicting emotionally positive and negative content. In line with the assumption that emotional distancing is an essential feature of the art experience we found that positive emotional reactions were attenuated (joy, M. zygomaticus activation) in an art compared to non-art context. However, context had little influence on negative emotional reactions (anger, disgust, fear, sadness, shame, and M. corrugator activation) suggesting that these are similar in art and non-art. Importantly, only artworks of emotionally negative content were judged more positively in an art context — thus liked more. This study, in accordance with the assumption of a distanced aesthetic mode, shows that an art context fosters appraisal processes that influence emotional experiences, allowing to judge negative stimuli aesthetically more positively — thus suppressing the immediacy of emotional stimulus content.