Hemispheric asymmetry and human associative learning: Interactions with attention

In a previous study (Hugdahl & Brobeck, 1986) it was shown that Pavlovian conditioning to an auditory verbal conditioned stimulus (CS) initially presented only to the left cerebral hemisphere was stronger than when the same CS was presented to the right hemisphere. This was followed up in the present study by controlling for the possibility that the effect was caused by laterally biased attention. The study was performed using the “dichotic extinction paradigm,” which consists of three different phases. During the habituation phase, the CS+ and CS- were presented binaurally and separated in time. During the acquisition phase, the CS+ was followed by a white-noise unconditioned stimulus (UCS). During the dichotic extinction phase, the CS+ and CS- were presented dichotically, i.e., simultaneous presentations on each trial. Half of the subjects had the CS+ in the right ear, and half had the CS+ in the left ear. Each group was further divided into two subgroups, with one subgroup instructed to attend only to the right ear input, and the other subgroup to attend only to the left ear input. During acquisition, larger electrodermal responses were obtained to the CS+ than to the CS-. During dichotic extinction, the CS+ right ear group showed superior resistance to extinction compared to the CS+ left ear group, with no effect of the manipulation of attention. The effect was, however, attenuated when levels of acquisition was used as covariates in an analysis of covariance. There were overall larger responses from the left hand recording.     

Brain asymmetry and autonomic conditioning: Sensitization control

In the present experiment we report effects of cerebral asymmetry, or laterality, during classical conditioning to facial emotional stimuli. Twenty-five female subjects were presented with slides of a happy face in one visual half-field (VHF), and simultaneously a slide of an angry face in the other VHF, followed by shock as the unconditioned stimulus (UCS). To control for effects of sensitization, a new stimulus, never associated with the UCS, was introduced in the extinction phase. Dependent measures were phasic heart rate responses (HR) and skin conductance responses (SCR). The HR results showed a significant right hemisphere effect for the CS-UCS association, that was not attributable to UCS sensitization. No significant effects were found for the SCRs. The basic HR finding was a right hemisphere superiority for learning of a conditioned association.     

Psychological characteristics of elderly insomniacs

Sixty insomniacs, aged 60 years or over, fulfilling the DSM-IV criteria for primary insomnia, completed a set of questionnaires measuring psychological distress. These included the Sleep Impairment Index (SIM), the Symptom Check List 90-Revised (SCL-90-R), the Penn State Worry Questionnaire (PSWQ), the Toronto Alexithymia Scale-20 (TAS-20) and the Elders Life Stress Inventory (ELSI). The insomniacs were compared on these measures with two contrast groups, one of elderly good sleepers and one an elderly community sample. As norms were developed for the SCL-90-R and PSWQ, insomniacs were also contrasted with the norm groups on these measures. In general, the results indicated a higher level of psychological distress among insomniacs than among the good sleepers, while there were negligible differences between insomniacs and the community sample on most measures. Overall, elderly insomniacs scored higher on measures of worry compared with the other groups, followed by measures of somatization, obsessive-compulsion and depression. It is concluded that excessive worrying was the most characteristic feature of elderly insomniacs.     

Infant responsiveness and maternal confidence in the neonatal period

Responsiveness in prematurely and term-born infants was studied cross-sectionally in relation to maternal confidence. Orientation and arousal were measured in 140 prematurely (mean BW 1,398 g, GA 30.1 weeks) and 75 term-born infants (mean BW 3,613 g, GA 39.3 weeks) with the Neonatal Behavioral Assessment Scales. Mothers filled out the Maternal Confidence Questionnaire and a modified version of the Parenting Stress Index. Prematurely born infants had a significantly lower level of arousal than term-born neonates. Responsiveness was not associated with maternal confidence. Lower confidence was associated with primiparity in both groups of mothers. Multiparous mothers of prematurely born infants had significantly lower levels of confidence than multiparous mothers of term-born infants. Confidence was significantly associated with stress for mothers of prematurely and term-born infants, and may be focused in follow-up after giving birth. Prematurely born infants should be examined more thoroughly in aspects of arousal at the time of discharge.     

Gene–Environment Interaction of the Oxytocin Receptor Gene Polymorphism (rs53576) and Unresolved Attachment Status Predict Depersonalization Symptoms: An Exploratory Study

Depersonalization (DP), or feelings of detachment from one’s self or one’s surroundings (i.e., derealization, DR), is considered a maladaptive stress response, frequently occurring in anxiety disorders, depression or as a primary disorder. However, the pathogenesis of DP/DR symptoms is little understood. The present study aimed to elucidate the influence of unresolved attachment status and the oxytocin receptor gene (OXTR) rs53576 polymorphism on DP/DR symptoms. The study sample consisted of 84 women, including 43 depressed patients and 41 control subjects, aged 19–52. DP/DR symptoms were measured with the Cambridge Depersonalization Scale; unresolved attachment status was assessed with the Adult Attachment Interview. OXTR rs53576 genotypes were obtained from blood samples. We found a highly significant gene–environment interaction: Individuals with unresolved attachment status were significantly more depersonalized when they carried the GG-allele than A-allele carriers than not unresolved subjects. There was no statistically significant main influence of OXTR genotypes or unresolved attachment status on DP/DR symptoms. We suggest that the GG-allele and unresolved attachment status might be considered as risk factors in the etiology of DP/DR symptoms. Replication is needed in larger samples including male subjects.     

The Comprehensive Assessment of Psychopathic Personality (CAPP): content validation using prototypical analysis

The Comprehensive Assessment of Psychopathic Personality (CAPP; Cooke, Hart, Logan, & Michie, 2004) is a new personality-based model and clinical assessment of psychopathy. This study was the first to examine the content validity of the English-language CAPP. Content validation is a crucial part of the development and refinement of any new instrument. Prototypical analysis was used to evaluate the representativeness of CAPP symptoms to the psychopathy construct in adults. Symptoms were rated by international mental health professionals (N = 132). Findings support good content validity of the CAPP, with most symptoms rated as highly representative of psychopathy. Domains relating to interpersonal style were particularly prototypical. Confirmatory factor analyses further suggested that CAPP domains are highly unidimensional. However, some CAPP symptoms may be weaker items in the model and further refinement is needed.