The neuroendocrinology of posttraumatic stress disorder: new directions

Studies of the hypothalamic-pituitary-adrenal (HPA) axis in persons with posttraumatic stress disorder (PTSD) have produced variable findings. This review focuses on the factors likely to have affected the outcome of these studies, including population characteristics and experimental design. Also discussed is a possible role for the adrenal neurosteroid dehydroepiandrosterone (DHEA) as a mediator of HPA axis adaptation to extreme stress and the psychiatric symptoms associated with PTSD. The antiglucocorticoid properties of DHEA may contribute to an upregulation of HPA axis responses as well as mitigate possible deleterious effects of high cortisol levels on the brain in some PTSD subpopulations. The neuromodulatory effects of DHEA and its metabolite DHEAS at gamma-aminobutyric acid and N-methyl-D-aspartate receptors in the brain may contribute to psychiatric symptoms associated with PTSD. The possible importance of other neurohormone systems in modulating HPA axis and symptom responses to traumatic stress is also discussed. Understanding the complex interactions of these stress-responsive neurosteroid and peptide systems may help explain the variability in patterns of HPA axis adaptation, brain changes, and psychiatric symptoms observed in PTSD and lead to better targeting of preventive and therapeutic interventions.     

Volume contents

Volume Contents

Volume contents     

Newborn infants' sensitivity to perceptual cues to lexical and grammatical words.

In our study newborn infants were presented with lists of lexical and grammatical words prepared from natural maternal speech. The results show that newborns are able to categorically discriminate these sets of words based on a constellation of perceptual cues that distinguish them. This general ability to detect and categorically discriminate sets of words on the basis of multiple acoustic and phonological cues may provide a perceptual base that can help older infants bootstrap into the acquisition of grammatical categories and syntactic structure.     

ANTECEDENT FACTORS DIFFERENTIATING WOMEN AND MEN IN SCIENCE/ NONSCIENCE CAREERS

Factors that differentiate women and men who choose a science career from those who do not were investigated using longitudinal data from 1980 and 1990. The participants (N = 459) were ninth or twelfth graders at six midwestern high schools in 1980. Women in science compared to women in other careers were significantly more likely to value math and science for their future career goals, whereas men in science compared to men in other careers had significantly higher high school grade point averages in natural science and higher career aspirations. Not unexpectedly, both women and men in science careers compared to those in nonscience careers took more high school elective science courses because they wanted to, aspired to higher prestige careers as young adults, and attributed their math successes more to their ability. The male model accounted for more than twice the variance accounted for by the female model, and context variables were not predictive for either model. Suggestions for revising the model and improving the assessment of context influences are made. Implications for research and practice include designing and evaluating programs to increase the number of intellectually able girls valuing math and science as these relate to their future goals.     

Interventions With Juvenile Offenders: Strategies to Prevent Acting Out Behavior

In this article Moral Dilemma Discussion Groups, Just Communities, Positive Peer Culture and the EQUIP program are reviewed for their appropriateness for intervening with juvenile offenders in residential settings. The suitability of these interventions for diverse populations is also examined.     

Wepman test of auditory discrimination: What does it discriminate

This study investigated auditory discrimination as a function of ethnic group membership within the same socioeconomic status (SES). Subjects were 126 randomly selected six-year-old students attending schools in the lower SES community of southeast San Diego. Only students with no known speech or hearing defects and of normal intelligence were included. They were assigned to one of three categories: Black, Chicano, or Anglo.Subjects were administered four tests in a counterbalanced design: the Wepman, the Gross, and the Ott. The latter two were developed for use with Black dialect and Spanish-speaking youngsters, respectively. The ANOVA results indicated a reliable difference between the main effects of the groups (F=40.34,p<.001) and tests (F=72.82, p<.001), with a significant interaction between tests and groups (F=44.91, p<.001). Interaction effects were evaluated with the Dunn theorem. Significant differences were found among Anglo, Black, and Chicano students on the discrimination list for Spanish sounds (Ott) and a significant Anglo/Black difference on the discrimination test for Black dialect (Gross). Contrary to previous findings, there were no differences between the groups on the Wepman Test of Auditory Discrimination (WTAD). However, there are significant differences between groups on separate items of this test.     

LEADERSHIP AND NONVERBAL BEHAVIORS OF HISPANIC FEMALES ACROSS SCHOOL EQUITY ENVIRONMENTS

Nonverbal behaviors of Hispanic elementary school students and their peers were examined in a small-group cooperative task with a total of 202 subjects. Thirty-five randomly selected groups were videotaped in ten desegregated schools; each group was gender-homogeneous, with three Hispanic and three Anglo students. Analysis of the videotapes revealed that Hispanic females used less vertical and horizontal space than Anglo females, and were also less likely to verbally interrupt or physically intrude on other group members. They had similar rates of handling the group resource cards and were given similar leadership scores by multi-ethnic trained observers. Among males, Hispanics are significantly more likely to use vertical or upward movements and physical intrusions, while Anglos use more verbal interruptions.
School and social status factors such as high-and low-equity desegregated school programs, ethnic and gender status, and school status variables of academic grades and English word knowledge had varying effects on teacher and peer ratings of leadership. High-equity schools garnered higher leadership scores for Hispanic females from both peers and teachers when all other nonverbal behaviors were controlled. This positive effect of the school on leadership ratings was evident only for males in teacher ratings. Hispanic females and their peers do reflect adult models of nonverbal behavior and leadership, and that leadership is enhanced in the perceptions of teachers and peers when they participate in a high-equity desegregated elementary school.