Incongruent object/context relationships in visual scenes: Where are they processed in the brain?

Rapid object visual categorization in briefly flashed natural scenes is influenced by the surrounding context. The neural correlates underlying reduced categorization performance in response to incongruent object/context associations remain unclear and were investigated in the present study using fMRI. Participants were instructed to categorize objects in briefly presented scenes (exposure duration = 100 ms). Half of the scenes consisted of objects pasted in an expected (congruent) context, whereas for the other half, objects were embedded in incongruent contexts. Object categorization was more accurate and faster in congruent relative to incongruent scenes. Moreover, we found that the two types of scenes elicited different patterns of cerebral activation. In particular, the processing of incongruent scenes induced increased activations in the parahippocampal cortex, as well as in the right frontal cortex. This higher activity may indicate additional neural processing of the novel (non experienced) contextual associations that were inherent to the incongruent scenes. Moreover, our results suggest that the locus of object categorization impairment due to contextual incongruence is in the right anterior parahippocampal cortex. Indeed in this region activity was correlated with the reaction time increase observed with incongruent scenes. Representations for associations between objects and their usual context of appearance might be encoded in the right anterior parahippocampal cortex.     

Predictive Genetic Testing in Children: Constitutional Mismatch Repair Deficiency Cancer Predisposing Syndrome

Biallelic germline mutations in mismatch repair genes predispose to constitutional mismatch repair deficiency syndrome (CMMR-D). The condition is characterized by a broad spectrum of early-onset tumors, including hematological, brain and bowel and is frequently associated with features of Neurofibromatosis type 1. Few definitive screening recommendations have been suggested and no published reports have described predictive testing. We report on the first case of predictive testing for CMMR-D following the identification of two non-consanguineous parents, with the same heterozygous mutation in MLH1: c.1528C > T. The genetic counseling offered to the family, for their two at-risk daughters, is discussed with a focus on the ethical considerations of testing children for known cancer-causing variants. The challenges that are encountered when reporting on heterozygosity in a child younger than 18 years (disclosure of carrier status and risk for Lynch syndrome), when discovered during testing for homozygosity, are addressed. In addition, the identification of CMMR-D in a three year old, and the recommended clinical surveillance that was proposed for this individual is discussed. Despite predictive testing and presymptomatic screening, the sudden death of the child with CMMR-D syndrome occurred 6 months after her last surveillance MRI. This report further highlights the difficulty of developing guidelines, as a result of the rarity of cases and diversity of presentation.     

Comparing Education,Employment, Social Support and Well-being among Youth with Disabilities and Their Peers in South Africa

Youth with disabilities face many challenges in life which are thought to have a negative impact on their well-being. Evidence, however, suggests that individuals differ in their resilience to deal with adverse life-events and protect their well-being. These differences may be explained by an individual’s resources such as education, employment, and social support. Studies on how youth with disabilities perceive their well-being and resources important to their well-being are, however, lacking. In this study we therefore compared education, employment, social support, and well-being between youth with disabilities (n?=?120) and their peers (n?=?117) in South Africa. In addition, we investigated the relationship between background characteristics, having a disability, access to resources, and well-being. The unemployment rate among youth with disabilities is higher, they are less educated, receive less social support and report poorer states of well-being. Our study showed that having a disability, social support, and employment were associated with the well-being of youth in South Africa. While having a disability predicted well-being in youth, the effect was mediated by employment and social support, indicating that those two resources influence wellbeing through both a direct and buffer effect. Therefore, employment and social support may mitigate the negative consequences of a disability and have a substantial role in improving or maintaining well-being.     

Über den Einfluß des phänomenalen Abstandes auf die Unterschiedsschwelle für Helligkeiten

Ohne Zusammenfassung Mit 12 Textabbildungen.     

Conscientiousness and adherence to the oral contraceptive pill: a cross-sectional analysis of the facets of conscientiousness

We examine the association between a six-facet model of conscientiousness and adherence to the Oral Contraceptive Pill (OCP), to investigate if these 6 facets can account for variation in adherence to the OCP. Cross-sectional data were collected from an opportunity sample of 243 female participants who were current users of the OCP, via online survey. Data were analysed using correlation and standard regression. The 60-item Chernyshenko Conscientiousness Scale (CCS), the 10-item IPIP Conscientiousness (IPIP C) subscale and the 5-item OCP Medication Adherence Report Scale (MARS) were employed. Both the total CCS (ρ = ?0.26, p < 0.01) and the IPIP C scale (ρ = ?0.22, p < 0.01) were associated with MARS. All facets measured by the CCS had small to medium-sized statistically significant correlations (r > ?0.18 and r < ?0.23, p < 0.05) with OCP adherence with the exception of traditionalism. Within a multivariable model, the six facets accounted for 7.1% of variance (p < 0.01) in adherence to the OCP. No one facet made a significant unique contribution to the model. These findings replicate and extend previous links between conscientiousness and OCP adherence. Further research should be conducted to establish the reliability of these findings in a general population of OCP users. Future interventions should focus on the development of interventions which take conscientiousness into consideration.     

Parent–Child Interaction Therapy with Toddlers in a community-based setting: Improvements in parenting behavior,emotional availability,child behavior,and attachment

Parent–Child Interaction Therapy with Toddlers (PCIT-T) is a new attachment-based parenting intervention designed to meet the needs of children aged 12–24 months presenting with challenging behaviors. This study examined outcomes of the first phase of PCIT-T, Child Directed Interaction–Toddler (CDI-T), 4-months post treatment. Participants were 56 toddlers (Child Mage = 19.13 months) referred to receive CDI-T over an 8-week period at an Australian community-based child behavior treatment clinic for treatment of difficult toddler behaviors. Participants completed questionnaires and observational measures at baseline (Time 1), post-treatment (Time 2), and 4-month follow-up (Time 3). At both Time 2 and Time 3, there were statistically significant increases in observed positive parenting skills and emotional availability and decreases in negative parenting behaviors and child noncompliance. There were also significant improvements in parent-reported child externalizing and internalizing behaviors, parental stress, and maternal depression. There was a pattern of a shift away from attachment insecurity and attachment disorganization. Results suggest that the CDI-T phase of PCIT-T is a promising intervention for toddlers presenting with behavioral issues. Future studies should be conducted to assess efficacy in other settings, using larger samples and utilizing randomized controlled designs.     

Parent engagement in an original and culturally adapted evidence-based parenting program,Legacy for Children™

Legacy for Children™ (Legacy) is an evidence-based program focused on promoting sensitive, responsive parenting for socioeconomically disadvantaged families. Legacy has recently been culturally and linguistically adapted for Spanish-monolingual Latino families and is being piloted in partnership with an early childhood education program. We conducted a mixed methods study to identify barriers and facilitators to engagement, using program monitoring data sources from both participant and group leader perspectives. We conducted qualitative analyses of open-ended data to identify distinct barriers (e.g., employment challenges, health-related challenges and appointments) and facilitators (e.g., other mothers in group, interest in program topics) to engagement that emerged across English and Spanish language curriculum versions; curriculum-specific barriers and facilitators were also documented. We interpret these findings in light of quantitative data on measures of engagement, showing that participants in the Spanish curriculum evidenced comparable levels of parent–group leader relationship quality relative to the English group, and higher levels of parent's group support/connectedness and overall satisfaction. These results offer promising considerations for optimizing families’ engagement in parenting programs in the context of early care and education settings.