Stem cell research: a target article collection: Part II--what's in a name: embryos,clones, and stem cells

In 2001, the U.S. House of Representatives passed the "Human Cloning Prohibition Act" and President Bush announced his decision to allow only limited research on existing stem cell lines but not on "embryos." In contrast, the U.K. has explicitly authorized "therapeutic cloning." Much more will be said about bioethical, legal, and social implications, but subtleties of the science and careful definitions of terms have received much less consideration. Legislators and reporters struggle to discuss "cloning," "pluripotency," "stem cells," and "embryos," and whether "adult" are preferable to "embryonic" stem cells as research subjects. They profess to abhor "copying humans" or "killing embryos." Do they know what they are talking about? Do we? This paper explores the historical, philosophical, and scientific contexts that inform this heated discussion.     

When it hurts to be misled: A Stroop-like effect in a simple addition production task

In four experiments, subjects saw simple addition equations (e.g., 3 + 4 = 9) and produced the sums while ignoring the presented answer. If the presented answer was false, subjects took longer to produce the sum, as compared with when the presented answer was true (Experiment 1), when there was no answer presented (blanks; Experiment 2), when a letter was presented (Experiment 3), and when a symbol was presented (Experiment 4). The results suggest that subjects were unable to ignore the presented answers, which raises problems for theories of arithmetic verification (i.e., deciding whether 3 + 4 = 9 is true or false) that claim that subjects verify equations by first producing the sum and then comparing the produced sum with the presented answer. Our results are more compatible with theories that claim that in verification and production, an arithmetic knowledge base is used in different ways.     

Evolving research misconduct policies and their significance for physical scientists

Scientific misconduct includes the fabrication, falsification, and plagiarism (FFP) of concepts, data or ideas; some institutions in the United States have expanded this concept to include “other serious deviations (OSD) from accepted research practice.” It is the absence of this OSD clause that distinguishes scientific misconduct policies of the past from the “research misconduct” policies that should be the basis of future federal policy in this area. This paper introduces a standard for judging whether an action should be considered research misconduct as distinguished from scientific misconduct: by this standard, research misconduct must involve activities unique to the practice of science and must have the potential to negatively affect the scientific record. Although the number of cases of scientific misconduct is uncertain (only the NIH and the NSF keep formal records), the costs are high in terms of the integrity of the scientific record, diversions from research to investigate allegations, ruined careers of those eventually exonerated, and erosion of public confidence in science. Existing scientific misconduct policies vary from institution to institution and from government agency to government agency; some have highly developed guidelines that include OSD, others have no guidelines at all. One result has been that the federal False Claims Act has been used to pursue allegations of scientific misconduct. As a consequence, such allegations have been adjudicated in federal courts, rather than judged by scientific peers. The federal government is now establishing a first-ever research misconduct policy that would apply to all research funded by the federal government regardless of which agency funded the research or whether the research was carried out in a government, industrial or university laboratory. Physical scientists, who up to now have only infrequently been the subject of scientific misconduct allegations, must nonetheless become active in the debate over research misconduct policies and how they are implemented since they will now be explicitly covered by this new federal wide policy. Disclaimer: The authors are grateful for the support for conduct of this research provided by the United States Department of Energy (DOE). The views expressed in this paper are solely those of the authors and were formed and expressed without reference to positions taken by DOE or the Pacific Northwest National Laboratory (PNNL). The views of the authors are not intended either to reflect or imply positions of DOE or PNNL.     

Premodern, modern, and postmodern perspectives on sex and gender mixes

Postmodern sensibilities, generally associated with relational psychoanalysis, are applicable also in traditional and contemporary Freudian psychoanalytic contexts. Historically speaking, views of femininity and female sexuality may be ordered according to positions designated as premodern, modern, and postmodern. This temporal continuum provides a basis for incorporating aspects of postmodern feminist approaches to deconstructing gender into a more traditional yet contemporary psychoanalytic framework. The postmodern "crisis of category" is addressed through a critique from a modern psychoanalytic point of view of the gender stereotyping inherent in certain false binaries and either/or thinking of premodern psychoanalytic thinking regarding female (as well as male) sex and gender. The cultural changes brought about by the consciousness-raising of postmodern feminist and contemporary psychoanalytic thinking contribute significantly to evolutionary changes in the understanding of gender that are further internalized and represented intrapsychically. That is, sequential transformations in the internalization of new cultural norms influence the development of still more new cultural norms, so that progression in these identificatory markers of gender can be observed over successive generations.     

The role of change in the relationship between commitment and turnover: a latent growth modeling approach

Through the use of affective, normative, and continuance commitment in a multivariate 2nd-order factor latent growth modeling approach, the authors observed linear negative trajectories that characterized the changes in individuals across time in both affective and normative commitment. In turn, an individual's intention to quit the organization was characterized by a positive trajectory. A significant association was also found between the change trajectories such that the steeper the decline in an individual's affective and normative commitments across time, the greater the rate of increase in that individual's intention to quit, and, further, the greater the likelihood that the person actually left the organization over the next 9 months. Findings regarding continuance commitment and its components were mixed.     

The relation between children's reading comprehension level and their comprehension of idioms

We report an investigation of 9-year-olds' ability to interpret idioms in relation to their reading comprehension level. We manipulated whether the idioms were transparent or opaque, whether they were real or novel, whether they were presented in isolation or in a supportive narrative context. As predicted, children were better able to explain the meanings of idioms in context than in isolation. The good and poor comprehenders did not differ in their abilities to interpret transparent idioms in context, but the poor comprehenders were significantly worse at using context to work out the meanings of opaque idioms. The explanation task revealed the source of information used by the children to derive nontarget interpretations. We discuss these findings in relation to idiom processing strategies and Levorato and Cacciari's global elaboration model.     

The mediating role of parental expectations in culture and well-being

In two studies, we examined the role of perceived fulfillment of parental expectations in the subjective well-being of college students. In Study 1, we found that American college students reported having higher levels of life satisfaction and self-esteem than did Japanese college students. American college students also reported having fulfilled parental expectations to a greater degree than did Japanese college students. Most importantly, the cultural difference in well-being was mediated by perceived fulfillment of parental expectations. In Study 2, we replicated the mediational finding with Asian American and European American college students. Asian American participants also perceived their parents' expectations about their academic performance to be more specific than did European Americans, which was associated with the cultural difference in perceived fulfillment of parental expectations. In short, perceived parental expectations play an important role in the cultural difference in the well-being of Asians and European Americans.     

Accounting for belief bias in a mental model framework: comment on Klauer, Musch, and Naumer (2000)

K. C. Klauer, J. Musch, and B. Naumer (2000; see record 2000-02818-008) presented a general multinomial model of belief bias effects in syllogistic reasoning. They claimed to map a particular mental model account of belief bias (J. V. Oakhill, P. N. Johnson-Laird, & A. Garnham, 1989; see record 1989-38845-001)) onto this model and to show empirically that it is incorrect. The authors argue that this mental model account does not map onto the multinomial model and that it can account for the data presented by Klauer et al. (Experiments 1-4). The authors further argue that additional data Klauer et al. presented in support of a new model of their own (Experiments 5-8) are explained by this mental model account. The mental model account is, therefore, refuted neither by Klauer et al.'s theoretical analysis nor by any of the results they presented. Furthermore, the account can accommodate more recent findings on belief bias in a more satisfactory way than can alternative models that have been proposed.     

Testing comprehension abilities in users of British Sign Language following CVA

Recent imaging (e.g., MacSweeney et al., 2002) and lesion (Hickok, Love-Geffen, & Klima, 2002) studies suggest that sign language comprehension depends primarily on left hemisphere structures. However, this may not be true of all aspects of comprehension. For example, there is evidence that the processing of topographic space in sign may be vulnerable to right hemisphere damage (e.g., Hickok, Say, Bellugi, & Klima, 1996), and the influence of iconicity on comprehension has yet to be explored. In this study, comprehension testing was conducted with 15 signers with unilateral brain damage, and with elderly Deaf controls. Four tests were administered: a test of iconic and non-iconic noun comprehension, a test of verb and sentence comprehension, a test of locative sentence comprehension, and a test of classifier comprehension. All tests were administered in British Sign Language (BSL), a language that has only recently been explored with lesioned signers (see Atkinson, Marshall, Thacker, & Woll, 2004; Marshall, Atkinson, Thacker, Woll, & Smulevitch, 2004; Marshall, Atkinson, Woll, & Thacker, in press). People with left hemisphere damage were impaired relative to controls on all tests. Those with right hemisphere damage performed well in the first two tests, but were impaired on locative sentences and classifiers. Neither group showed any effect of iconicity. The results shed further light on the laterality of sign language comprehension.