γ节律神经振荡：反映自闭症多感觉整合失调的一项重要生物指标

多感觉整合是对不同感官信息进行选择、联系、统一乃至解释的加工过程, 它需要神经系统不同功能区域的共同投入与相互协调, 以实现多种感觉信息的时间捆绑以及全局性的预测编码。而γ神经振荡因具有反映神经皮层兴奋/抑制的平衡状况, 实现多感官信息的时间同步, 以及通过跨频耦合实现全局性预测编码的特点, 在多感觉整合的加工过程中发挥着重要作用。相比正常个体, 自闭症患者神经系统中的GABA中间神经元存在结构与功能异常, 导致γ神经振荡紊乱, 由此破坏了正常的时间同步以及预测编码加工, 并最终引发多感觉整合失调。基于上述因果关联, 未来研究可结合无创可逆性干预技术, 以γ节律神经振荡为生物反馈指标, 形成科学系统化的临床干预治疗方案。     

Widowhood and the Subjective Well-Being of Older People in China: the Mediating Effects of Lifestyle

Applied Research in Quality of Life - Previous research has illustrated that lifestyle is correlated with widowhood and subjective well-being amongst older people; however, few studies have...     

Belief in a Just World and Employee Voice Behavior: The Mediating Roles of Perceived Efficacy and Risk

Abstract

In this research, we hypothesized that employees’ belief in a just world (BJW) would be positively related to their voice behavior, i.e., the expression of ideas or opinions with the intention of engendering organizational improvement or change, and that this relation would be mediated by perceived voice efficacy and perceived voice risk. To test these hypotheses, we collected self-reported data from employees in two different countries: China (N?=?313) and Germany (N?=?190). The results revealed a positive association between BJW and employee voice behavior in both samples. The two-mediator model was confirmed in the Chinese sample, while only perceived voice efficacy played a mediating role in the German sample. Possible reasons for these differences may be related to differences in cultural dimensions and education levels between the samples. The findings emphasize the importance of bolstering employees’ belief in justice and the organizational climate, which influence perceived voice efficacy and risk, as means to increase organizational voice behavior.     

Understanding Leisure Trip Experience and Subjective Well-Being: an Illustration of Creative Travel Experience

Applied Research in Quality of Life - Leisure activities provide an opportunity to stimulate an individual’s creative potential, making positive contributions to health and well-being. Using...     

Constraints have different concurrent effects and aftereffects on variability

Three experiments showed that constraints imposed early in learning have different effects on variability when they are in effect and after they are removed. Task constraints, which determine how something can be done, limited the number of possible responses in a computer game. Variability constraints, which specify how differently something must be done, required that each response differ from some number of prior responses. Less restrictive constraints (Experiments 1 and 2) produced higher variability during the constraints. More restrictive constraints (Experiments 2 and 3) led to higher variability after the constraints were relaxed. The authors discuss how these differences reflect strategies acquired during the constraints (default rules) and modified in closely related ways (exception rules) afterward.     

Lateralization of narrow-band noise by blind and sighted listeners

The effects of varying interaural time delay (ITD) and interaural intensity difference (IID) were measured in normal-hearing sighted and congenitally blind subjects as a function of eleven frequencies and at sound pressure levels of 70 and 90 dB, and at a sensation level of 25 dB (sensation level refers to the pressure level of the sound above its threshold for the individual subject). Using an 'acoustic' pointing paradigm, the subject varied the IID of a 500 Hz narrow-band (100 Hz) noise (the 'pointer') to coincide with the apparent lateral position of a 'target' ITD stimulus. ITDs of 0, +/-200, and +/-400 micros were obtained through total waveform delays of narrow-band noise, including envelope and fine structure. For both groups, the results of this experiment confirm the traditional view of binaural hearing for like stimuli: non-zero ITDs produce little perceived lateral displacement away from 0 IID at frequencies above 1250 Hz. To the extent that greater magnitude of lateralization for a given ITD, presentation level, and center frequency can be equated with superior localization abilities, blind listeners appear at least comparable and even somewhat better than sighted subjects, especially when attending to signals in the periphery. The present findings suggest that blind listeners are fully able to utilize the cues for spatial hearing, and that vision is not a mandatory prerequisite for the calibration of human spatial hearing.     

Change in cognitive functioning associated with apoE genotype in a community sample of older adults

The influence of a genetic risk factor, apolipoprotein E (apoE) epsilon4 variant, was assessed in older adults aged 70 to 94 on 3 occasions over 7 years. The results of latent growth curve analyses are reported for individuals genotyped for apoE at the 2nd measurement occasion (n = 601) and for a subsample of individuals without probable or definite dementia during the 1st or 2nd occasion (n = 434). ApoE-epsilon4 status was a significant predictor of level and change in memory performance and change in speed performance in the full sample, and of initial level and change in memory performance in the nondemented subsample. These results support previous findings that apoE-epsilon4 is associated with accelerated memory deterioration in individuals without clinical dementia.     

Employment of persons with disabilities in information technology jobs: literature review for "IT works"

This article reviews relevant literature as to the labor pool of qualified individuals with disabilities and employment in information technology (IT) sector jobs. First, the article reviews the empirical literature on barriers to employment in IT for persons with disabilities. The examination then is extended to studies of barriers to employment for individuals with disabilities in other employment sectors. Findings illustrate the limited experiences that IT and non-IT companies have in employing and accommodating employees with disabilities. Implications are discussed for enhancing the employment of qualified workers with disabilities in IT through research, education, training, and mentoring programs.