Risk seeking for losses modulates the functional connectivity of the default mode and left frontoparietal networks in young males

Value-based decision making (VBDM) is a principle that states that humans and other species adapt their behavior according to the dynamic subjective values of the chosen or unchosen options. The neural bases of this process have been extensively investigated using task-based fMRI and lesion studies. However, the growing field of resting-state functional connectivity (RSFC) may shed light on the organization and function of brain connections across different decision-making domains. With this aim, we used independent component analysis to study the brain network dynamics in a large cohort of young males (N = 145) and the relationship of these dynamics with VBDM. Participants completed a battery of behavioral tests that evaluated delay aversion, risk seeking for losses, risk aversion for gains, and loss aversion, followed by an RSFC scan session. We identified a set of large-scale brain networks and conducted our analysis only on the default mode network (DMN) and networks comprising cognitive control, appetitive-driven, and reward-processing regions. Higher risk seeking for losses was associated with increased connectivity between medial temporal regions, frontal regions, and the DMN. Higher risk seeking for losses was also associated with increased coupling between the left frontoparietal network and occipital cortices. These associations illustrate the participation of brain regions involved in prospective thinking, affective decision making, and visual processing in participants who are greater risk-seekers, and they demonstrate the sensitivity of RSFC to detect brain connectivity differences associated with distinct VBDM parameters.     

Optimal Designs for the Rasch Model

In this paper, optimal designs will be derived for estimating the ability parameters of the Rasch model when difficulty parameters are known. It is well established that a design is locally D-optimal if the ability and difficulty coincide. But locally optimal designs require that the ability parameters to be estimated are known. To attenuate this very restrictive assumption, prior knowledge on the ability parameter may be incorporated within a Bayesian approach. Several symmetric weight distributions, e.g., uniform, normal and logistic distributions, will be considered. Furthermore, maximin efficient designs are developed where the minimal efficiency is maximized over a specified range of ability parameters.     

Coping variables as predictors of perioperative emotional states and adjustment

Abstract

Surgery, regardless of its kind and severity, can be regarded as a major stress situation for any patient. High preoperative emotional arousal may negatively influence adaptation during surgery and, consequently, rate of postoperative recovery. In a series of previous studies, our research group analyzed the influence of dispositional and actual coping on subjective and objective stress indicators before, during, and after surgery. The present study investigates the influence of the dispositional coping variables vigilance and cognitive avoidance on actual surgery-related coping, state anxiety, and indicators of intra- and postoperative adjustment. The sample consisted of 42 male and 42 female patients undergoing elective maxillofacial surgery under general anaesthesia. Dispositional coping was measured on the dimensions vigilance and cognitive avoidance with the Mainz Coping Inventory. Actual surgery-related coping was assessed by means of a newly constructed inventory containing items to measure the four dimensions avoidance, vigilance, positive restructuring, and seeking social support.

Self-reported state anxiety was differentiated according to the cognitive, affective, and somatic components. The patients' adaptation was assessed by measuring doses of the narcotic agents used for induction of anaesthesia, the intraoperative status, and the amount of postoperative (analgesic and psychotropic) medication. Significant effects of coping mode, gender, and time of measurement were observed on the cognitive, affective and somatic component of state anxiety, the indicators of intraoperative adaptation and on postoperative medication. Also, patients' actual coping behavior could partly be predicted by dispositional coping. Results indicate that actual coping behavior and gender should be taken into account when trying to predict adaptation and developing psychological preparatory intervention programs.     

How to get really smart: Modeling retest and training effects in ability testing using computer-generated figural matrix items

The interpretation of retest scores is problematic because they are potentially affected by measurement and predictive bias, which impact construct validity, and because their size differs as a function of various factors. This paper investigates the construct stability of scores on a figural matrices test and models retest effects at the level of the individual test taker as a function of covariates (simple retest vs. training, use of identical vs. parallel retest forms, and general mental ability). A total of N = 189 subjects took two tests of matrix items that were automatically generated according to a strict construction rationale. Between test administrations, participants in the intervention groups received training, while controls did not. The Rasch model fit the data at both time points, but there was a lack of item difficulty parameter invariance across time. Training increased test performance beyond simple retesting, but there was no large difference between the identical and parallel retest forms at the individual level. Individuals varied greatly in how they profited from retest experience, training, and the use of identical vs. parallel retest forms. The results suggest that even with carefully designed tasks, it is problematic to directly compare scores from initial tests and retests. Test administrators should emphasize learning potential instead of state level assessment, and inter-individual differences with regard to test experience should be taken into account when interpreting test results.     

Switching, induction of rapid cycling, and increased suicidality with antidepressants in bipolar patients: fact or overinterpretation?

Antidepressants constitute a central cornerstone in the treatment of depressive syndromes. In bipolar patients, however, there is an ongoing controversy about their usefulness for at least 3 decades. Early reports, mainly concerning tricyclic antidepressants, have repeatedly pointed toward unfavorable side effects on the course of the disorder, namely switching into (hypo)mania, induction of rapid cycling, and increased risk of suicide. Most evidence for both unfavorable and favorable effects has been deducted, thus far, from small studies with methodological flaws. More substantiated evidence only recently became available. From this it appears that, at least, the switch risk, and perhaps also the risk for rapid cycling and new-onset suicidality have been overinterpreted. At the same time, these new data raise doubt about the efficacy of antidepressants as a primary-treatment choice in bipolar depression.     

Transition Discontinuities and the Biographical Shaping of Early Work Careers

Because of the restructuring of work and deregulation of the labor market school-to-work transitions have been predicted to become destandardized. These structural changes will finally also erode Germany's renowned dual system of apprenticeship training. From an economic-structural point of view it is likely that young persons' social integration and biographical plans can no longer rely on this occupation-driven transition arrangement. Based on a quantitative and qualitative longitudinal study with young adults in two German labor-market regions, this exploratory study shows that the dual system not only trains for certain occupations, but also socializes for the contingencies of the labor market. The results are interpreted in the new conceptual framework of self-socialization, which links individual agency with social contexts across the life course in terms of a biography-environment fit. Applied to transition discontinuities and shifting contexts of career development, processes of self-socialization are reflected in different modes of biographical agency in the shaping of early employment careers. Self-initiated and enforced discontinuous employment and occupational change are mediated by various constellations of occupational contexts and modes of biographical agency. The study suggests that for young adults the dual system still provides skills and orientations for coping with career discontinuity.