Test-retest reliability of fMRI during nonverbal semantic decisions in moderate-severe nonfluent aphasia patients

Cortical reorganization in poststroke aphasia is not well understood. Few studies have investigated neural mechanisms underlying language recovery in severe aphasia patients, who are typically viewed as having a poor prognosis for language recovery. Although test-retest reliability is routinely demonstrated during collection of language data in single-subject aphasia research, this is rarely examined in fMRI studies investigating the underlying neural mechanisms in aphasia recovery. The purpose of this study was to acquire fMRI test-retest data examining semantic decisions both within and between two aphasia patients. Functional MRI was utilized to image individuals with chronic, moderate-severe nonfluent aphasia during nonverbal, yes/no button-box semantic judgments of iconic sentences presented in the Computer-assisted Visual Communication (C-ViC) program. We investigated the critical issue of intra-subject reliability by exploring similarities and differences in regions of activation during participants' performance of identical tasks twice on the same day. Each participant demonstrated high intra-subject reliability, with response decrements typical of task familiarity. Differences between participants included greater left hemisphere perilesional activation in the individual with better response to C-ViC training. This study provides fMRI reliability in chronic nonfluent aphasia, and adds to evidence supporting differences in individual cortical reorganization in aphasia recovery.     

Optimism, promotion pride, and prevention pride as predictors of quality of life

The relationship between optimism and two potential sources of optimistic beliefs--promotion pride (based on a history of success in promotion regulation) and prevention pride (based on a history of success in prevention regulation)--was explored. Optimism was more strongly related to promotion pride than prevention pride (controlling for neuroticism), consistent with past work showing that anticipating success increases eagerness motivation but decreases vigilance motivation. This suggests that the psychology of prevention regulators is not captured well by the existing literature on optimism. Although prevention pride does not predict self-reports of well-being, it does predict adaptive functioning independent of optimism, neuroticism, and promotion pride. Promotion pride uniquely predicted a sense of purpose in life or goal directedness. Both promotion and prevention pride predicted active coping. It is argued that promotion and prevention pride tell us something unique and important about the role of successful self-regulation in determining quality of life.     

Phonology competes with syntax: experimental evidence for the interaction of word order and accent placement in the realization of Information Structure

In this paper, we investigate the interaction of phonological and syntactic constraints on the realization of Information Structure in Greek, a free word order language. We use magnitude estimation as our experimental paradigm, which allows us to quantify the influence of a given linguistic constraint on the acceptability of a sentence. We present results from two experiments. In the first experiment, we focus on the interaction of word order and context. In the second experiment, we investigate the additional effect of accent placement and clitic doubling. The results show that word order, in contrast to standard assumptions in the theoretical literature, plays only a secondary role in marking the Information Structure of a sentence. Order preferences are relatively weak and can be overridden by constraints on accent placement and clitic doubling. Our experiments also demonstrate that a null context shows the same preference pattern as an all focus context, indicating that 'default' word order and accent placement (in the absence of context) can be explained in terms of Information Structure. In the theoretical part of this paper, we formalize the interaction of syntactic and phonological constraints on Information Structure. We argue that this interaction is best captured using a notion of grammatical competition, such as the one developed by Optimality Theory (Prince & Smolensky, 1993, Optimality theory: constraint interaction in generative grammar (Technical Report No. 2). Center for Cognitive Science, Rutgers University, Piscataway, NJ; Science 275 (1997) 1604). In particular, we exploit the optimality theoretic concept of constraint ranking to account for the fact that some constraint violations are more serious than others. We extend standard Optimality Theory to obtain a grammar model that predicts not only the optimal (i.e. grammatical) realization of a given input, but also makes predictions about the relative grammaticality of suboptimal structures. This allows us to derive a constraint hierarchy that accounts for the interaction of phonological and syntactic constraints on Information Structure and models the acceptability patterns found in the experimental data.     

Psychotherapy Process Measure Research and the Evaluation of Psychotherapy Orientation: A Narrative Analysis

This article discusses the need for a systematic method that enables researchers to evaluate integrative therapy approaches using a range of therapy process measures. The Narrative System Process Coding (NPCS; Angus, Hardtke, & Levitt, 1996) is proposed as such a method, and is applied with the Experiencing Scale (Klein, Mathieu, Gendlin, & Keisler, 1970) and the Levels of Client Perceptual Processing (LCPP; Toukmanian, 1986) to three brief good outcome integrative therapy modalities to illustrate this need. The study found higher Experiencing Scale scores to be most strongly related to an experiential approach to therapy and to the NPCS internal narrative processes. Higher LCPP scores were most strongly related to the NPCS reflexive narrative process and to a perceptual-processing approach. The discussion initiates a discourse on the importance of explicating process measures' origins when comparing different therapy approaches in order to allow for the meaningful consolidation of process research findings.     

Assessment of executive functioning in childhood epilepsy: the Tower of London and BRIEF

Children and adolescents with epilepsy are known to demonstrate executive function dysfunction, including working memory deficits and planning deficits. Accordingly, assessing specific executive function skills is important when evaluating these individuals. The present investigation examined the utility of two measures of executive functions-the Tower of London and the Behavioral Rating Inventory of Executive Functioning (BRIEF)-in a pediatric epilepsy sample. Ninety clinically referred children and adolescents with seizures were included. Both the Tower of London and BRIEF identified executive dysfunction in these individuals, but only the Tower of London variables showed significant relations with epilepsy severity variables such as age of epilepsy onset, seizure frequency, number of antiepileptic medications, etc. Further, the Tower of London and BRIEF variables were uncorrelated. Results indicate that objective measures of executive function deficits are more closely related to epilepsy severity but may not predict observable deficits, as reported by parents. Comprehensive evaluation of such deficits, therefore, should include both objective measures as well as subjective ratings from caregivers.     

A Model of Therapist Competencies for the Empirically Supported Interpersonal Psychotherapy for Adolescent Depression

In order to treat adolescent depression, a number of empirically supported treatments (ESTs) have been developed from both the cognitive behavioral therapy (CBT) and interpersonal psychotherapy (IPT-A) frameworks. Research has shown that in order for these treatments to be implemented in routine clinical practice (RCP), effective therapist training must be generated and provided. However, before such training can be developed, a good understanding of the therapist competencies needed to implement these ESTs is required. Sburlati et al. (Clin Child Fam Psychol Rev 14:89–109, 2011) developed a model of therapist competencies for implementing CBT using the well-established Delphi technique. Given that IPT-A differs considerably to CBT, the current study aims to develop a model of therapist competencies for the implementation of IPT-A using a similar procedure as that applied in Sburlati et al. (Clin Child Fam Psychol Rev 14:89–109, 2011). This method involved: (1) identifying and reviewing an empirically supported IPT-A approach, (2) extracting therapist competencies required for the implementation of IPT-A, (3) consulting with a panel of IPT-A experts to generate an overall model of therapist competencies, and (4) validating the overall model with the IPT-A manual author. The resultant model offers an empirically derived set of competencies necessary for effectively treating adolescent depression using IPT-A and has wide implications for the development of therapist training, competence assessment measures, and evidence-based practice guidelines. This model, therefore, provides an empirical framework for the development of dissemination and implementation programs aimed at ensuring that adolescents with depression receive effective care in RCP settings. Key similarities and differences between CBT and IPT-A, and the therapist competencies required for implementing these treatments, are also highlighted throughout this article.     

An event in medical life,or the advent of a belief?

Freud's ambivalent relations with medicine are well known. Based on his relatively unknown text, A religious experience, published in 1928, the authors present an analysis of the internal reasons for this conflict. Responding to a letter from an American doctor, who tells him about his reactions to an autopsy and the influence it had on his religious faith, Freud suggests an analysis that leads him to make a surprising slip. This slip reveals the conflicts inherent in the practice of autopsy, considered as a peculiar event in medical training that puts a strain on the future medical practitioner's subjectivity. Based on the analysis of unconscious impulses and fantasmatic activity, the authors demonstrate that Freud's theory is still surprisingly relevant today in the light of testimonies from contemporary doctors confronted with autopsy during their training or daily practice.     

Predicting the performance and innovativeness of scientists and engineers

A study of 644 scientists and engineers from 5 corporate research and development organizations investigated hypotheses generated from an interactionist framework of 4 individual characteristics as longitudinal predictors of performance and innovativeness. An innovative orientation predicted 1-year-later and 5-years-later supervisory job performance ratings and 5-years-later counts of patents and publications. An internal locus of control predicted 5-years-later patents and publications, and self-esteem predicted performance ratings for both times and patents. Team-level nonroutine tasks moderated the individual-level relationships between an innovative orientation and performance ratings and patents such that the relationships were stronger in a nonroutine task environment. Implications for an interactionist framework of performance and innovativeness for knowledge workers are discussed.