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Pauli WM Clark AD Guenther HJ O'Reilly RC Rudy JW 《Learning & memory (Cold Spring Harbor, N.Y.)》2012,19(7):307-314
Evidence suggests that two regions of the striatum contribute differential support to instrumental response selection. The dorsomedial striatum (DMS) is thought to support expectancy-mediated actions, and the dorsolateral striatum (DLS) is thought to support habits. Currently it is unclear whether these regions store task-relevant information or just coordinate the learning and retention of these solutions by other brain regions. To address this issue, we developed a two-lever concurrent variable-interval reinforcement operant conditioning task and used it to assess the trained rat's sensitivity to contingency shifts. Consistent with the view that these two regions make different contributions to actions and habits, injecting the NMDA antagonist DL-AP5 into the DMS just prior to the shift impaired the rat's performance but enhanced performance when injected into the DLS. To determine if these regions support memory content, we first trained rats on a biased concurrent schedule (Lever 1: VI 40" and Lever 2: VI 10"). With the intent of "erasing" the memory content stored in striatum, after this training we inhibited the putative memory-maintenance protein kinase C isozyme protein kinase Mζ (PKMζ). Infusing zeta inhibitory peptide (ZIP) into the DLS enhanced the rat's ability to adapt to the contingency shift 2 d later, whereas injecting it into the DMS had the opposite effect. Infusing GluR2(3Y) into the DMS 1 h before ZIP infusions prevented ZIP from impairing the rat's sensitivity to the contingency shift. These results support the hypothesis that the DMS stores information needed to support actions and the DLS stores information needed to support habits. 相似文献
223.
Ina Fassbender Arnold Lohaus Hoben Thomas Manuel Teubert Marc Vierhaus Sibylle M. Spangler Thorsten Kolling Claudia Goertz Frauke Graf Bettina Lamm Helene Gudi Claudia Freitag Heidi Keller Monika Knopf Gudrun Schwarzer 《Infant and child development》2012,21(4):325-337
This longitudinal study assessed 133 Caucasian German infants at 3 and 6 months of age to investigate the influence of own‐race and other‐race faces as visual stimuli on association learning in the visual expectation paradigm (VExP). The study is related to the findings on the other‐race‐effect (ORE) which is said to emerge at 6 months of age. Caucasian faces were used as stimuli of a familiar ethnic category, whereas African faces were used as stimuli of an unfamiliar ethnic category. There was no significant difference between the two stimulus classes in infants' reaction time (RT) to stimulus shifts at 3 months. At 6 months of age, infants' RT decreased significantly in the Caucasian faces condition but not in the African faces condition. These results indicate that the processing of other‐race versus own‐race faces by the age of 6 months, which is also the relevant age for the onset of the ORE, has an important influence on the performance on the VExP. Copyright © 2011 John Wiley & Sons, Ltd. 相似文献
224.
Frauke Graf Bettina Lamm Claudia Goertz Thorsten Kolling Claudia Freitag Sibylle Spangler Ina Fassbender Manuel Teubert Marc Vierhaus Heidi Keller Arnold Lohaus Gudrun Schwarzer Monika Knopf 《Infant and child development》2012,21(5):458-473
Three‐month‐old Cameroonian Nso farmer and German middle‐class infants were compared regarding learning and retention in a computerized mobile task. Infants achieving a preset learning criterion during reinforcement were tested for immediate and long‐term retention measured in terms of an increased response rate after reinforcement and after a 24‐h delay compared with baseline. It was hypothesized that infants from both cultural communities would acquire the contingency between own motion and mobile movement, as they similarly experience contingent responses in social interactions. Nso infants were assumed to show a higher learning rate related to their advanced gross motor development, whereas German infants were expected to show a higher baseline because of culture‐typical motor handling promoting a high level of activity (i.e. lying supine). Results showed immediate and long‐term retention in infants from both cultural contexts, as well as a higher baseline for German infants. Although the learning rate was higher for Cameroonian infants, logistic regression revealed that learning was not related to gross motor development but depended on the level of baseline response. Thus, contingency learning was shown in different cultural environments, and the level of baseline activity coined by culture‐specific motor handling turned out to influence learning within the mobile task. Copyright © 2012 John Wiley & Sons, Ltd. 相似文献
225.
Attachment anxiety has been associated with a hyperactivating response to threat. A modified emotional Stroop task was used to investigate temporal characteristics of the threat response by assessing response latencies to interpersonally threatening words (immediate interference) and two directly subsequent neutral filler words (delayed interference). Greater immediate and delayed interference to threatening words was observed (n = 125), with higher levels of attachment anxiety associated with immediate interference to threatening cues, and lower levels with delayed interference. Thus, attachment anxiety was related to the speed at which moderate perceived threat disrupted ongoing processes under top-down attentional control. Furthermore, top-down attentional control moderated the extent to which immediate or delayed interference was observed. Among participants who demonstrated relatively stronger top-down attentional control, immediate and delayed interference to threatening cues was minimal, suggesting that results involving emotional Stroop interference were primarily attributable to participants with relatively weaker top-down attentional control. The implications of these findings are considered within the broader context of performance-based and neuroimaging research, with suggestions for future applied research. 相似文献
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Alyssa A. Rheingold Carla Kmett Danielson Tatiana M. Davidson Shannon Self-Brown Heidi Resnick 《Journal of child and family studies》2013,22(3):386-397
Children who disclose child sexual abuse are often referred for a comprehensive medical exam to ensure physical well-being and gather evidence. This study examined a brief, developmentally appropriate, psychoeducational video designed to instruct children and caregivers about the exam procedures and coping strategies to be used during the exam. Sixty-nine children ages 4–15 and their caregivers were randomly assigned to view the psychoeducational video (n = 35) or to receive standard practice (n = 34). Distress before, during, and after the exam was assessed in both children and caregiver, as were measures of satisfaction and knowledge about the investigation process and coping strategies. Consistent with hypotheses, results indicated that the video intervention was well-received by families, increased caregiver knowledge, and decreased stress during the examination. Caregiver and child distress decreased from pre to post examination across both conditions, and, unexpectedly, there were no significant differences in these decreases between groups. Overall results from this pilot study are promising in supporting a cost-effective and brief early intervention approach at the time of the medical examination for child sexual abuse for children and their caregivers. 相似文献
230.
Heidi Vandebosch 《Deviant behavior》2013,34(6):541-570
When researchers investigate the relationships between media behavior and criminal behavior, they tend to focus on the links between the content preferences of offenders and the types of crime they have committed. Offenders, however, also differ with respect to their degree of criminal involvement. Although some authors indicate that the consumption of socially disvalued media contents may have a symbolic value for people with a high degree of criminal involvement, or suggest that media may provide them with useful information, the link between this criminality dimension and media use has seldom been thoroughly studied. This article describes the results of a qualitative and quantitative study into the media use of prisoners in five Flemish penitentiaries. It illustrates that the variable degree of subjective criminal involvement is a particularly strong predictor of media uses, preferences, and interests among confined offenders. 相似文献