Incorporating Social Media into your Support Tool Box: Points to Consider from Genetics-Based Communities

Patients with newly-described or rare genetic findings are turning to social media to find and connect with others. Blogs, Facebook groups, and Twitter have all been reported as tools for patients to connect with one another. However, the preferences for social media use and privacy among patients, their families, and these communities have not been well characterized. To explore preferences about privacy and membership guidelines, an online survey was administered to two web-based patient registries, Simons Variation in Individuals Project (www.simonsvipconnect.org) and GenomeConnect (www.genomeconnect.org). Over a three-month period, invitations were sent to 2524 individuals and 103 responses (4%) were received and analyzed. Responses indicate that Facebook is the most popular resource accessed within this sample population (99%). Participants used social media to look for information about their diagnosis or test results (83%), read posts from rare disease groups or organizations (73%), participate in conversations about their diagnosis (67%), and connect with others to find support (58%). Focusing on privacy issues in social media, respondents indicate that membership and access impact the level of comfort in sharing personal or medical information. Nearly 60% of respondents felt uncomfortable sharing photos or medical information within a public Facebook group, whereas only 12% of respondents felt uncomfortable sharing in private group targeted to families alone. Using this preliminary data concerning social media use and privacy, we developed points for genetic counselors to incorporate when discussing available support resources for patients with a new, or rare, genetic diagnosis or genetic test result. Genetic counselors are trained to provide anticipatory guidance to families adapting to new genetic information, and are well-equipped to help patients consider their preferences about using social media as a source of information and support.     

The heart of control: Proactive cognitive control training limits anxious cardiac arousal under stress

Research and theory suggest that anxious people employ cognitive control on a relatively late and transient basis. This tendency may impair emotion regulation that depends on early, persistent implementation of cognitive control. We examined whether anxious people could be trained to apply cognitive control proactively (i.e., in advance of goal-related action) and whether such training limited anxiety’s rise during stress. In Study 1, 96 high trait-anxious participants completed proactive or reactive training followed by the Trier Social Stress Test (TSST) with measurement of subjective anxiety, heart rate, and skin conductance level (SCL). In Study 2, 59 high trait-anxious participants completed a proactive or no-instruction training for 4 days and then completed the TSST. For Study 2 but not Study 1, the proactive versus control training was associated with lower stress-related increases in subjective anxiety and heart rate, but not sympathetically mediated SCL. Exercising proactive control may leverage the parasympathetic nervous system to inhibit the escalation of anxious arousal during stress.     

5-HTTLPR X Stress in Adolescent Depression: Moderation by MAOA and Gender

Depression surges in adolescence, especially among girls. Most evidence indicates that the short allele of a polymorphism in the promoter region of the serotonin transporter gene (5-HTTLPR) interacts with stress to influence the onset of depression. This effect appears to be less robust in adolescents, particularly among boys, and may be moderated by other genetic polymorphisms. Seeking to explain the adolescent gender difference in depression, this study examined the effects of 5-HTTLPR (rs25531), the monoamine oxidase A-upstream variable number tandem repeat (MAOA-uVNTR), and negative life events (NLE). A community-based longitudinal sample of 309 adolescents reported depressive symptoms and NLE at ages 11, 13, and 15. 5-HTTLPR and MAOA-uVNTR genotypes were ascertained via buccal swabs. A significant four-way interaction of 5-HTTLPR, MAOA-uVNTR, NLE at age 13, and gender predicted depressive symptoms at age 15. Girls were most likely to exhibit elevated depressive symptoms when experiencing NLE if they possessed low-expression MAOA-uVNTR alleles and short 5-HTTLPR alleles, whereas low-expression MAOA-uVNTR alleles but long 5-HTTLPR alleles were implicated in boys. The results indicate that the commonly reported 5-HTTLPR by stress interaction for depression may be limited to individuals with low-expression MAOA-uVNTR alleles. These data also provide new evidence that the short allele of 5-HTTLPR confers susceptibility to stress differently for females compared with males.     

Examining mental simulations of uncertain events

A great deal of research into the experiential nature of language has demonstrated that our understanding of events is facilitated through mental simulations of the described linguistic input. However, to date little is understood about how contextual uncertainty about the described event might influence the content and strength of these mental representations or the cognitive effort involved. In this article, we report a single experiment in which participants read sentences such as “The old lady [knows/thinks] that the picnic basket is open.” Following a delay of 250 or 1,500 ms, they responded to pictures that varied in the physical form of the target object (matching vs. mismatching). Results revealed an expected facilitation effect for matching images, but more important, they also showed interference effects (longer reaction times) at the shorter interstimulus interval (ISI; 250 ms) following the uncertain verb thinks, as compared with the certain verb knows. At the longer ISI, this effect was no longer present. This suggests that at the short ISI, uncertain conditions required extra time to construct and map a simulation of events onto the available image. Results are discussed in terms of the mechanisms involved in representing possible events and with reference to related literature on perspective taking.     

A further examination of the lexical-processing stages hypothesized by the E-Z Reader model

Participants’ eye movements were monitored while they read sentences in which high- and low-frequency target words were presented normally (i.e., the normal condition) or with either reduced stimulus quality (i.e., the faint condition) or alternating lower- and uppercase letters (i.e., the case-alternated condition). Both the stimulus quality and case alternation manipulations interacted with word frequency for the gaze duration measure, such that the magnitude of word frequency effects was increased relative to the normal condition. However, stimulus quality (but not case alternation) interacted with word frequency for the early fixation time measures (i.e., first fixation, single fixation), whereas case alternation (but not stimulus quality) interacted with word frequency for the later fixation time measures (i.e., total time, go-past time). We interpret this pattern of results as evidence that stimulus quality influences an earlier stage of lexical processing than does case alternation, and we discuss the implications of our results for models of eye movement control during reading.     

The Role of Social Cognition in the Religious Fundamentalism‐Prejudice Relationship

The study examines the indirect effects of religious fundamentalism on prejudice through cognitive style and fear of invalidity. Undergraduates (n= 199) completed measures of religious fundamentalism, homophobia, modern racism, hostile and benevolent sexism, need for cognition, need for structure, preference for consistency, and fear of invalidity. Need for cognition partially mediated the relationship between religious fundamentalism and both homophobia and benevolent sexism. Preference for consistency partially mediated the relationship between religious fundamentalism and hostile sexism. The indirect effect of religious fundamentalism on modern racism through preference for consistency approached statistical significance. The interaction between need for structure and fear of invalidity partially mediated the relationship between religious fundamentalism and both homophobia and hostile sexism, with individuals high in need for structure and low in fear of invalidity having higher religious fundamentalism and prejudice.     

Implicit theories of relationships: moderators of the link between conflict and commitment

In two studies, implicit theories of relationships were examined as moderators of the association between experienced conflict and commitment. Study 1 involved 128 individuals in heterosexual romantic relationships and employed an event-contingent diary procedure in which disagreements were recorded throughout a 10-day period. Study 2 was conducted in the laboratory and involved 75 heterosexual couples who discussed problems in their relationship, with commitment measured before and after discussion. Multilevel random coefficient models revealed that conflict was generally associated with lower commitment but less so with growth belief. Also, growth belief was most beneficial under negative relationship conditions, such as when one possessed a less favorable view of the partner to begin with and when the issue remained unresolved after discussion.