Animal spare parts? A Canadian public consultation on xenotransplantation

Xenotransplantation, or the use of animal cells, tissues and organs for humans, has been promoted as an important solution to the worldwide shortage of organs. While scientific studies continue to be done to address problems of rejection and the possibility of animal-to-human virus transfer, socio-ethical and legal questions have also been raised around informed consent, life-long monitoring, animal welfare and animal rights, and appropriate regulatory practices. Many calls have also been made to consult publics before policy decisions are made. This paper describes the Canadian public consultation process on xenotransplantation carried out by the Canadian Public Health Association in an arm’s length process from Health Canada, the ministry overseeing government health policy and regulation. Focusing on six citizen fora conducted around the country patterned after the citizen jury deliberative approach, the paper describes the citizen panelists’ recommendations to hold off on proceeding with clinical trials and the rationales behind this recommendation. The consultation process is discussed in the context of constructive technology assessment, a framework which argues for broader input into earlier stages of technology innovation, particularly at the technology design stage. This study was supported by a grant to the first author from the Social Sciences and Humanities Research Council in Canada.     

Opportunistic use of cognitive smokescreens by araneophagic jumping spiders

Little is known about how a prey species' cognitive limitations might shape a predator's prey-capture strategy. A specific hypothesis is investigated: predators take advantage of times when the prey's attention is focussed on its own prey. Portia fimbriata, an araneophagic jumping spider (Salticidae) from Queensland, is shown in a series of 11 experiments to exploit opportunistically a situation in which a web-building spider on which it preys, Zosis genicularis (Uloboridae), is preoccupied with wrapping up its own prey. Experimental evidence supports three conclusions: (1) while relying on optical cues alone, P. fimbriata perceives when Z. genicularis is wrapping up prey; (2) when busy wrapping up prey, the responsiveness of Z. genicularis to cues from potential predators is diminished; and (3) P. fimbriata moves primarily during intervals when Z. genicularis is busy wrapping up prey. P. fimbriata's strategy is effective partly because the wrapping behaviour of Z. genicularis masks the web signals generated by the advancing P. fimbriata's footsteps and also because, while wrapping, Z. genicularis' attention is diverted away from predator-revealing cues. Electronic Publication     

Emotion, plasticity, context, and regulation: perspectives from affective neuroscience

The authors present an overview of the neural bases of emotion. They underscore the role of the prefrontal cortex (PFC) and amygdala in 2 broad approach- and withdrawal-related emotion systems. Components and measures of affective style are identified. Emphasis is given to affective chronometry and a role for the PFC in this process is proposed. Plasticity in the central circuitry of emotion is considered, and implications of data showing experience-induced changes in the hippocampus for understanding psychopathology and stress-related symptoms are discussed. Two key forms of affective plasticity are described--context and regulation. A role for the hippocampus in context-dependent normal and dysfunctional emotional responding is proposed. Finally, implications of these data for understanding the impact on neural circuitry of interventions to promote positive affect and on mechanisms that govern health and disease are considered.     

The Ponzo illusion affects grip-force but not grip-aperture scaling during prehension movements

Contextual cues such as linear perspective and relative size can exert a powerful effect on the perception of objects. This fact is demonstrated by the illusory effects that can be induced by such cues (e.g., the Ponzo railway track and Titchener circles illusions). Several recent studies have reported, however, that visual illusions based on such cues have little or no influence on the visuomotor mechanisms used to guide hand action. Furthermore, evidence of this sort has been cited in support of a distinction between visual perception and the visual control of action. In the current study, the authors investigated the effect of the Ponzo visual illusion on the control of hand action, specifically, the scaling of grip force and grip aperture during prehension movements. The results demonstrate that grip force scaling is significantly influenced by the Ponzo visual illusion, whereas the scaling of grip aperture is unaffected by the illusion.     

The Psychosocial Adjustment to Illness Scale--Self-Report: factor structure and item stability

The Psychosocial Adjustment to Illness Scale--Self-Report (PAIS-SR; Derogatis & Derogatis, 1990), a frequently used measure of adjustment in medically ill adults, was subjected to several exploratory factor analyses, with principal-axes factor extractions and varimax rotation procedures. The sample consisted of kidney, heart, liver, lung, and bone marrow transplant candidates (N = 280). The final analysis yielded a six-factor, 26-item instrument accounting for 59% of the variance. Coefficient alpha for the 26-item measure was .87, and internal consistency estimates for the factors ranged from .50 to .86. Strong correlations with other adjustment measures commonly used in the assessment of adults with chronic physical conditions support the validity of the PAIS-SR.     

Secondary prevention interventions for young drug users: a systematic review of the evidence

This paper reviews the international scientific evidence on the effectiveness of secondary prevention interventions for young drug users. The review provides insight into the effectiveness of interventions that have been evaluated using moderately strong research designs. Most of the studies included are from the United States of America. Some interventions are effective in reducing drug use and associated problems while others have no or mixed effect. Those successful in reducing drug use include behavior therapy, Minnesota 12-step programs, residential care, and general drug treatment. Those with either no effect or mixed effect include schools interventions. Involving parents and other agencies may enhance an intervention's effect. There is a lack of good quality studies outside the USA. Future interventions should focus on either low- or high-risk groups of young drug users. Future research should be conducted on a wider range of services for young people and include non-medical outcomes such as communication skills, schooling, employment, family relations, and economic costs.     

Simple arithmetic processing: the question of automaticity

In adult simple arithmetic performance, it is commonly held that retrieval of solutions occurs automatically from a network of stored facts in memory. However, such an account of performance necessarily predicts a uniform reaction time for solution retrieval and is therefore not consistent with the robust finding that reaction time increases with problem size and difficulty. Additionally, past research into arithmetic performance has relied on tasks that may have actually induced and measured attentional processing, thereby possibly confounding previous results and conclusions pertaining to automaticity. The present study therefore, attempted to more reliably assess the influence of automatic processing in arithmetic performance by utilizing a variant of the well-established semantic word-priming procedure with a target-naming task. The overall results revealed significant facilitation in naming times at SOAs of 240 and 1000 ms for congruent targets i.e., targets that represented the correct solutions to problems presented as primes (e.g., 6+8 and 14). Significant inhibition in comparison to a neutral condition (0+0 and 17) was also observed at 120 and 240 ms SOAs in naming incongruent targets (e.g., 6+8 and 17). Furthermore, response times were found to vary as a function of both arithmetic fluency and problem size. Differences in performance to addition and multiplication operations and implications for cognitive research and education are considered.     

Conjoint developmental trajectories of young adult alcohol and tobacco use

Developmental and etiological advances have set the stage for considering trajectories of problem behavior across the life course, but little work thus far addresses co-occurring problem behavior trajectories. Although recent work characterizes drinking and smoking trajectories, none has explored the course of concurrent drinking and smoking. Using panel data from the Monitoring the Future Project (N=32,087), the authors applied growth mixture modeling to 4 waves of heavy drinking and smoking in a young-adult sample. The authors extracted a single latent group membership factor from heavy drinking and smoking. Associations between trajectory classes and risk factors were relatively unique to the substance being predicted. The association of smoking with alcohol expectancies and delinquency appeared to exist by virtue of smoking's comorbidity with drinking.     

Eating disorder prevention programs: a meta-analytic review

This meta-analysis of eating disorder prevention programs found that intervention effects ranged from an absence of any effects to reductions in current and future eating pathology. Certain effects persisted as long as 2 years and were superior to minimal-intervention control conditions. Larger effects occurred for selected (vs. universal), interactive (vs. didactic), and multisession (vs. single session) programs; for programs offered solely to females and to participants over age 15; for programs without psychoeducational content; and for trials that used validated measures. The results identify promising prevention programs and delineate sample, format, and design features that are associated with larger effects, but they suggest the need for improved methodological rigor and statistical modeling of trials and enhanced theoretical rationale for interventions.     

Shape-from-shading depends on visual, gravitational, and body-orientation cues

The perception of shading-defined form results from an interaction between shading cues and the frames of reference within which those cues are interpreted. In the absence of a clear source of illumination, the definition of 'up' becomes critical to deducing the perceived shape from a particular pattern of shading. In our experiments, twelve subjects adjusted the orientation of a planar disc painted with a linear luminance gradient from one side to the other, until the disc appeared maximally convex-that is, until the luminance gradient induced the maximum perception of a three-dimensional shape. The vision, gravity, and body-orientation cues were altered relative to each other. Visual cues were manipulated by the York Tilted Room facility, and body cues were altered by simply lying on one side. The orientation of the disc that appeared maximally convex varied in a systematic fashion with these manipulations. We present a model in which the direction of perceptual 'up' is determined from the sum of three weighted vectors corresponding to the vision, gravity, and body-orientation cues. The model predicts the perceived direction of 'up', contributes to our understanding of how shape-from-shading is deduced, and also predicts the confidence with which the 'up' direction is perceived.