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阿尔茨海默病(AD)是常见的中枢神经系统变性疾病,是痴呆最常见的病因,发病率高.病理特征为老年斑及神经元纤维缠结.AD的确诊有赖病理学,临床诊断极其耗时.由于尚无准确的早期诊断方法,常使AD患者错过早期治疗的时机,这成为制约有效防控AD的瓶颈问题.因此寻找高敏感性、特异性、无创性的生物学标志物对AD的早期诊断至关重要.本文仅将目前较为广泛研究的生物学标志物及其研究现状作一概述.分别对脑脊液、血液、尿液及唾液中的AD标志物作逐一介绍. 相似文献
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The Wallach–Kogan Creativity Tests were translated into Chinese and later fully computerized for research in Hong Kong. The normative data of two cohorts (1994 and 2002) of school children were employed to test the hypothesis that growth in creative thinking occurs in a society or culture during a period of education and curriculum reforms that emphasize creative thinking. Results of multivariate analysis of variance and subsequent univariate analysis of variance supported the hypothesis. Moreover, some interesting gender differences in creativity growth were observed, underlining the fact that boys and girls should be treated differentially to obtain a desirable creativity growth for them. 相似文献
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Over the past decade, research at three different levels of sensorimotor control has revealed a degree of complexity that challenges traditional hypotheses regarding servocontrol of individual muscles: (a) The connectivity of spinal circuits is much more divergent and convergent than expected. (b) The normal and reflex-induced recruitment of individual muscles and compartments of muscles is more finely controlled than was noted previously. (c) The mechanical interactions among linked skeletal segments and their often multiarticular muscles are neither simple nor intuitively obvious. We have developed a mathematical model of the cat hind limb that permits us to examine the influence of individual muscles on posture and gait. We have used linear quadratic control theory to predict the optimal distribution of feedback from a hypothetical set of proprioceptors, given different assumptions about the behavioral goals of the animal. The changes in these predictions that result from changes in the structure and control objectives of the model may provide insights into the functions actually performed by the various circuits in the spinal cord. 相似文献
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This study tested the greater male variability hypothesis in creative thinking with a Chinese student sample in Mainland China. The Test for Creative Thinking-Drawing Production (TCT-DP) was administered to 627 Chinese adolescent boys (n = 332) and girls (n = 295). Results using the boy/girl variance ratio (VR) generally supported the hypothesis that boys have greater variability than girls in creativity test performance. However, results using the boy/girl ratios from different regions of the creativity score distribution revealed a pattern of male superiority. While boys significantly outnumbered girls in the higher extremes, girls tended to outnumber boys in the central region and the lower extremes. Results from an analysis of the means lent further support to the findings of male superiority. Plausible explanations for greater male variability and male superiority in Mainland China are proposed. The theoretical and practical implications of the findings are discussed. 相似文献
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We investigated how age of faces and emotion expressed in faces affect young (n=30) and older (n=20) adults’ visual inspection while viewing faces and judging their expressions. Overall, expression identification was better for young than older faces, suggesting that interpreting expressions in young faces is easier than in older faces, even for older participants. Moreover, there were age-group differences in misattributions of expressions, in that young participants were more likely to label disgusted faces as angry, whereas older adults were more likely to label angry faces as disgusted. In addition to effects of emotion expressed in faces, age of faces affected visual inspection of faces: Both young and older participants spent more time looking at own-age than other-age faces, with longer looking at own-age faces predicting better own-age expression identification. Thus, cues used in expression identification may shift as a function of emotion and age of faces, in interaction with age of participants. 相似文献
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We report the study of the effect of strain rate on the compressive behaviour of a Zr56Al10.9Ni4.6Cu27.8Nb0.7 bulk metallic glass. The results indicated that both the strength and plasticity of the glass increase with increasing the strain rate up to 10?5 s?1, above which the strength and plasticity start to decrease. The enhanced mechanical properties under a strain rate of 10?5 s?1 are due to the emission/propagation rate of the shear bands being consistent with the strain rate. 相似文献