Does Response Inhibition Have Pre- and Postdiagnostic Utility in Parkinson's Disease?

ABSTRACT. Parkinson's disease (Pd) is the second most prevalent degenerative neurological condition worldwide. Improving and sustaining quality of life is an important goal for Parkinson's patients. Key areas of focus to achieve this goal include earlier diagnosis and individualized treatment. In this review the authors discuss impulse control in Pd and examine how measures of impulse control from a response inhibition task may provide clinically useful information (a) within an objective test battery to aid earlier diagnosis of Pd and (b) in postdiagnostic Pd, to better identify individuals at risk of developing impulse control disorders with dopaminergic medication.     

Why computational models are better than verbal theories: the case of nonword repetition

Tests of nonword repetition (NWR) have often been used to examine children's phonological knowledge and word learning abilities. However, theories of NWR primarily explain performance either in terms of phonological working memory or long‐term knowledge, with little consideration of how these processes interact. One theoretical account that focuses specifically on the interaction between short‐term and long‐term memory is the chunking hypothesis. Chunking occurs because of repeated exposure to meaningful stimulus items, resulting in the items becoming grouped (or chunked); once chunked, the items can be represented in short‐term memory using one chunk rather than one chunk per item. We tested several predictions of the chunking hypothesis by presenting 5–6‐year‐old children with three tests of NWR that were either high, medium, or low in wordlikeness. The results did not show strong support for the chunking hypothesis, suggesting that chunking fails to fully explain children's NWR behavior. However, simulations using a computational implementation of chunking (namely CLASSIC, or Chunking Lexical And Sub‐lexical Sequences In Children) show that, when the linguistic input to 5–6‐year‐old children is estimated in a reasonable way, the children's data are matched across all three NWR tests. These results have three implications for the field: (a) a chunking account can explain key NWR phenomena in 5–6‐year‐old children; (b) tests of chunking accounts require a detailed specification both of the chunking mechanism itself and of the input on which the chunking mechanism operates; and (c) verbal theories emphasizing the role of long‐term knowledge (such as chunking) are not precise enough to make detailed predictions about experimental data, but computational implementations of the theories can bridge the gap.     

BETWEEN LIBERATION(S) AND OCCUPATION(S): RECONSIDERING THE EMERGENCE OF MAGHREBI JEWISH COMMUNISM, 1942–1945

From the fall of France in 1940 to the Anglo-American liberation of North Africa from Vichy rule (in Morocco and Algeria) and German occupation (in Tunisia), from November 1942 to May 1943, the Second World War profoundly transformed North African youth. For young French-educated Jews living in urban colonial spaces, disillusionment with Vichy France's betrayal of democracy and equality led them to a search for new political models, including Communism.

Through the memoirs of three North African Jews that came to politics through local Communist parties, Abraham Serfaty, Daniel Timsit and Gilbert Naccache, Communism in its wartime form (allied with Western democracies) provided an ideal mediating force. For a generation that wanted to fight against the anti-Jewish measures of the Vichy and Nazi regimes, as well as to abolish colonial distinctions between indigenous Jews and Muslims and Europeans, Communism proposed radical equality in a supra-national framework. As the authors/activists look back on the failures of decolonization, they attempt to make sense of their political commitments by gesturing to a utopian moment when Jews could be grounded in local struggles while looking to the US, the Soviet Union, and Popular Front France as models for equality.     

Positive and Negative Affective Dysfunction in Psychopathology

Moods are a constant feature of human experience. Although we all experience good and bad moods, there are individual differences in the propensity to experience positive and negative feeling states. These individual differences are assessed as traits under the terms positive affectivity (PA) and negative affectivity (NA), respectively. Studying the relations between PA, NA, and psychopathology has provided a basic understanding of emotional dysfunction in a range of symptoms and disorders. A substantial body of evidence indicates that general NA is a core feature of many types of psychopathology. In contrast, the relations for general PA are more varied, as it correlates negatively with some disorders but positively with others. Additionally, some research has investigated how more specific components of PA and NA relate to psychological disorders and their symptoms. However, further research of this type is needed to improve our conceptualization of emotional dysfunction across disorders.     

Aspirin Use is Associated with Lower Prostate Cancer Risk in Male Carriers of BRCA Mutations

Previous studies have shown that male BRCA mutation carriers stand at increased risk of developing prostate cancer and have concerns about developing cancer. Genetic counseling practitioners often discuss strategies for reducing the risk of cancer for patients at high risk due to their genetic background. Addressing modifiable health habits is one such strategy. Unfortunately, modifiable risk factors for prostate cancer have only been documented in the general population and have not yet been studied in the BRCA carrier subpopulation. Therefore, this study aimed to identify modifiable risk factors for prostate cancer in BRCA carriers. We examined prostate cancer risk factors in 74 men who were part of families with a BRCA mutation. This study examined nine dichotomous variables including: exercise, history of vasectomy, smoking history, alcohol use, finasteride use, statin use, aspirin use, coffee use, and vitamin use. The survey was sent to all cases of prostate cancer in the Hereditary Cancer Center Database at Creighton University with a known BRCA status. This study confirmed the protective benefits of daily aspirin use, which have been observed in previous studies of the general population, and suggests its benefit in BRCA carriers. Protective benefits from regular vigorous exercise and daily coffee use trended towards significance, but neither factor withstood the Bonferroni Correction for multiple comparisons.     

Verbal working memory predicts co-speech gesture: Evidence from individual differences

Gesture facilitates language production, but there is debate surrounding its exact role. It has been argued that gestures lighten the load on verbal working memory (VWM; Goldin-Meadow, Nusbaum, Kelly, & Wagner, 2001), but gestures have also been argued to aid in lexical retrieval (Krauss, 1998). In the current study, 50 speakers completed an individual differences battery that included measures of VWM and lexical retrieval. To elicit gesture, each speaker described short cartoon clips immediately after viewing. Measures of lexical retrieval did not predict spontaneous gesture rates, but lower VWM was associated with higher gesture rates, suggesting that gestures can facilitate language production by supporting VWM when resources are taxed. These data also suggest that individual variability in the propensity to gesture is partly linked to cognitive capacities.     

Resilience Among Women with HIV: Impact of Silencing the Self and Socioeconomic Factors

In the U.S., women account for over a quarter of the approximately 50,000 annual new HIV diagnoses and face intersecting and ubiquitous adversities including gender inequities, sexism, poverty, violence, and limited access to quality education and employment. Women are also subjected to prescribed gender roles such as silencing their needs in interpersonal relationships, which may lessen their ability to be resilient and function adaptively following adversity. Previous studies have often highlighted the struggles encountered by women with HIV without focusing on their strengths. The present cross-sectional study investigated the relationships of silencing the self and socioeconomic factors (education, employment, and income) with resilience in a sample of women with HIV. The sample consisted of 85 women with HIV, diverse ethnic/racial groups, aged 24–65 enrolled at the Chicago site of the Women’s Interagency HIV Study in the midwestern region of the United States. Measures included the Connor-Davidson Resilience Scale -10 item and the Silencing the Self Scale (STSS). Participants showed high levels of resilience. Women with lower scores on the STSS (lower self-silencing) reported significantly higher resilience compared to women with higher STSS scores. Although employment significantly related to higher resilience, silencing the self tended to predict resilience over and above the contributions of employment, income, and education. Results suggest that intervention and prevention efforts aimed at decreasing silencing the self and increasing employment opportunities may improve resilience.     

Assessing hopelessness in terminally ill cancer patients: development of the Hopelessness Assessment in Illness Questionnaire

Hopelessness has become an increasingly important construct in palliative care research, yet concerns exist regarding the utility of existing measures when applied to patients with a terminal illness. This article describes a series of studies focused on the exploration, development, and analysis of a measure of hopelessness specifically intended for use with terminally ill cancer patients. The 1st stage of measure development involved interviews with 13 palliative care experts and 30 terminally ill patients. Qualitative analysis of the patient interviews culminated in the development of a set of potential questionnaire items. In the 2nd study phase, we evaluated these preliminary items with a sample of 314 participants, using item response theory and classical test theory to identify optimal items and response format. These analyses generated an 8-item measure that we tested in a final study phase, using a 3rd sample (n = 228) to assess reliability and concurrent validity. These analyses demonstrated strong support for the Hopelessness Assessment in Illness Questionnaire providing greater explanatory power than existing measures of hopelessness and found little evidence that this assessment was confounded by illness-related variables (e.g., prognosis). In summary, these 3 studies suggest that this brief measure of hopelessness is particularly useful for palliative care settings. Further research is needed to assess the applicability of the measure to other populations and contexts.     

SenseCam improves memory for recent events and quality of life in a patient with memory retrieval difficulties

A wearable camera that takes pictures automatically, SenseCam, was used to generate images for rehearsal, promoting consolidation and retrieval of memories for significant events in a patient with memory retrieval deficits. SenseCam images of recent events were systematically reviewed over a 2-week period. Memory for these events was assessed throughout and longer-term recall was tested up to 6 months later. A written diary control condition followed the same procedure. The SenseCam review procedure resulted in significantly more details of an event being recalled, with twice as many details recalled at 6 months follow up compared to the written diary method. Self-report measures suggested autobiographical recollection was triggered by the SenseCam condition but not by reviewing the written diary. Emotional and social wellbeing questionnaires indicated improved confidence and decreased anxiety as a result of memory rehearsal using SenseCam images. We propose that SenseCam images provide a powerful boost to autobiographical recall, with secondary benefits for quality of life.