National evaluation of US newborn screening system components

Newborn screening has existed as a state-based public health service since the early 1960s. Every state and most territorial jurisdictions have comprehensive newborn screening programs in place, but in the United States a national newborn screening policy does not exist. This results in different administrative infrastructures, screening requirements, laboratory and follow-up services, medical management approaches, and related activities across the country. Federal initiatives and support have contributed to limited evaluations of various aspects of individual newborn screening programs at the national level, but funding is an issue. The national evaluation strategies have taken various forms, all with the intent of improving the screening system through review of actions taken and suggestions for future improvements. While participation in the national evaluation effort for newborn screening laboratory practices includes all US programs, and this has aided in improving quality and harmonizing protocols, other national evaluation activities have been only moderately successful. National data reporting of quality indicators for various program elements must be comprehensive and timely, and the elements must be universally accepted in order to meet the evaluation and improvement needs of the national newborn screening system. A comprehensive real time national evaluation activity will likely require additional resources and enforcement incentives. Limited federal actions through grant incentives and selected reporting requirements provide a possible means of stimulating programs to participate in national harmonization efforts.     

Stimulus-governance and the hyperkinetic syndrome

The hypothesis that hyperkinetic children are stimulusgoverned was tested. In a sample of 39 nonmedicated hyperkinetic boys 26 were found to be stimulus-governed. In a control sample of 20 nonmedicated boys 6 were found to be stimulus-governed. An association was found between the hyperkinetic syndrome and stimulusgovernance. The hypothesis is raised that response to methylphenidate is related to stimulusgovernance. Several issues raised by the research are discussed.This research was supported in part by a grant from Bloemendaal Psychiatric Hospital, The Hague, The Netherlands. The authors wish to thank Mr. E. M. Ockhorst, for constructing the KFA-testing equipment, and Mr. R. Reyneart, for helping with the computer analysis. An earlier draft of the paper was presented at the European Conference of Neuropsychology, sponsored by the International Neuropsychology Society, at Oxford University, England.     

The duration and perceived intensity of sucrose taste

Thirty-two subjects judged the perceived intensity of each of four concentrations of sucrose over 2 min. Stimuli were either sipped and expectorated or flowed over the subject’s extended tongue. Ratio judgments on a line scale and category ratings were made. Sixteen of the subjects had had extensive training in judging the sensory attributes of food products, and another group of 16 subjects were untrained. The perceived intensity of sucrose rose to a peak within 5 or 10 sec, and then declined over 2 min. In both the sip and the flow conditions, the taste disappeared completely for 26 of 32 subjects. Stronger concentrations were perceived as having greater peak intensities and longer lasting taste. The differences between concentrations were enhanced when sipped rather than flowed over the tongue. Judgments of intensity and duration were largely unaffected by the training level of subjects and the use of different rating scales.     

A jackknife test of homogeneity of variance with paired replicates data

A nonparametric test of dispersion with paired replicates data is described which involves jackknifing logarithmic transformations of the ratio of variance estimates for the pre- and post-treatment populations. Results from a Monte Carlo simulation show that the test performs well underH _o and has good power properties. Examples are given of applying the procedure on psychiatric data.A referee called our attention to valuable references which related to our work, and he suggested the inclusion of competing jackknife procedures into our studies.     

Foreign Investments in Southern Africa

“If one believes in the Prince of Peace one must stop committing crimes in the name of the Prince of Peace. The Christian Church still rules this world, it still has the power to change the structure of South Africa.” James Baldwin in his address to the Fourth Assembly of the World Council of Churches, Uppsala, 1968.     

A stimulus-compounding assay of conditioned inhibition and excitation

Rats were trained in an operant discrimination involving two panel lights, A and B. Group CI (Conditioned Inhibition) was trained to lever press in the presence of A (S+), and not in the presence of the compound AB (S?). The opposite contingencies held in Group CE (Conditioned Excitation). Response rates were higher in Group CE than in Group CI, especially to the positive stimulus. However, the groups acquired the discrimination at comparable rates. In a separate phase of the experiment, a tone (C) was separately trained in the absence of the lights to control responding. All seven possible combinations of A, B, and C were then presented randomly during extinction. The inhibitory effect of B on C in Group CI was comparable in magnitude to the excitatory effect of B on C in Group CE. B's effect on C was not altered by the presence or absence of A, regardless of whether A was inhibitory or excitatory. The symmetry between CI and CE revealed by the stimulus-compounding test may be partly artifactual.