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The 5-HT3 receptor for serotonin is expressed within limbic structures and is known to modulate neurotransmitter release, suggesting that this receptor may influence learning and memory. Perturbations in serotonergic neurotransmission lead to changes in the ability to attend, learn, and remember. To examine the role of 5-HT3 receptors in learning, memory, and attention, 5-HT3 receptor overexpressing (5-HT3-OE) transgenic mice and their wild-type littermates (WT) were tested in Pavlovian contextual and cued fear conditioning, fear extinction, and latent inhibition (LI) paradigms. Prepulse inhibition (PPI) was assessed to reveal changes in sensorimotor gating. Additionally, anxious behaviors, shock sensitivity, and reactions to novel stimuli were evaluated. 5-HT3-OE mice displayed enhanced contextual conditioning, whereas cued conditioning remained the same as that of WT mice. 5-HT3-OE mice did not differ from WT in extinction rates to either the context or cue. LI was enhanced for 5-HT3-OE mice compared to WT. PPI remained unchanged. No differences in sensitivity to footshock or startle were found. However, 5-HT3-OE mice demonstrated heightened exploratory behavior in response to novel environmental stimuli and decreased anxiety as measured in the elevated plus-maze. Results indicate that overexpression of the 5-HT3 receptor in mouse forebrain results in enhanced hippocampal-dependent learning and attention. Enhanced inspective behavior in response to novelty may contribute to the observed improvements in learning, memory, and attention due to 5-HT3 receptor overexpression.  相似文献   
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The participants were 360 Canadian undergraduates. After receiving written scenarios involving a campus visitor seeking direction to a nearby destination (simple route) or a distant destination (complex route), they drew maps to that destination. The authors varied the visitor's gender, age, and familiarity with campus. They analyzed the content of the students' maps in terms of cardial indicators (compass grid, correct north-south orientation), landmarks, labeled buildings, directional arrows, and supplemental written directions. The men tended to provide more cartographically complete maps than the women, though there were no gender differences in use of landmarks or labeled buildings. The men were significantly more inclined than the women to take visitor characteristics into account, providing more complete maps to visitors navigating complex routes, to newcomers, and to older visitors who were unfamiliar with the campus. The men had more confidence that their maps would successfully lead visitors to their destinations. Route complexity led to greater use of landmarks, labeled buildings, and cardinal indicators. The participants' self-reported familiarity with campus had little effect on their direction giving, except for a greater use of labeled buildings in maps.  相似文献   
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A survey of 263 employed men and women examined the effect of length of employment, perceived ability to find a better job, positive job features (pay, job security, and intrinsic interest), and perceived risk of occupational injury on intentions to stay with or leave one's current employer. Perceived risk of occupational injury significantly predicted one's belief that the person would not stay with the current employer. Perceived inability to find alternative employment lessened the desirability of leaving the current employer. Desire to leave was lower when a job was rated highly for pay, security, and intrinsic interest. Length of employment, as a measure of job commitment, was not a factor.  相似文献   
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In this essay I review the advantages and challenges of contingent faculty service from a perspective which crosses programs, but chiefly from within one academic institution, a church‐related but independent theological seminary. I anecdotally relate certain “value‐added” potentialities which accrue for students and instruction when an adjunct faculty's primary institutional connections are outside the academic environment. I cite benefits to the student, school, and instructor. See companion essays published in this issue of the journal by Hoon J. Lee, Adam Wirrig, Bradley Burroughs, and Kyle A. Schenkewitz.  相似文献   
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The productivity measurement and enhancement system: a meta-analysis   总被引:1,自引:0,他引:1  
Meta-analytic procedures were used to examine data from 83 field studies of the Productivity Measurement and Enhancement System (ProMES). The article expands the evidence on effectiveness of the intervention, examines where it has been successful, and explores moderators related to its success. Four research questions were explored and results indicate that (a) ProMES results in large improvements in productivity; (b) these effects last over time, in some cases years; (c) the intervention results in productivity improvements in many different types of settings (i.e., type of organization, type of work, type of worker, country); and (d) moderator variables are related to the degree of productivity improvement. These moderator variables include how closely the study followed the original ProMES methodology, the quality of feedback given, whether changes were made in the feedback system, the degree of interdependence of the work group, and centralization of the organization. Implications based on these findings are discussed for future use of this intervention, and the system is discussed as an example for evidence-based management.  相似文献   
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W. Andrew Harrell 《Sex roles》1986,15(9-10):467-478
Survey data collected from 450 male farmers in Canada revealed that three variables — conservative farming, willingness to risk life and limb to make a profit, and safe equipment operation — directly predicted the rate of serious farming-related accidents. Three dimensions of masculinity — suppression of emotions, “men in charge,” and recklessness — had strong indirect effects. Masculine recklessness tended to increase profit-oriented personal risk taking and to decrease the safe operation of farm equipment. Suppression of emotions also increased risk taking.  相似文献   
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