Beta1-adrenoceptor or alpha1-adrenoceptor activation initiates early odor preference learning in rat pups: support for the mitral cell/cAMP model of odor preference learning

We proposed that mitral cell beta1-adrenoceptor activation mediates rat pup odor preference learning. Here we evaluate beta1-, beta2-, alpha1-, and alpha2-adrenoceptor agonists in such learning. The beta1-adrenoceptor agonist, dobutamine, and the alpha1-adrenoceptor agonist, phenylephrine, induced learning, and both exhibited an inverted U-curve dose-response relationship to odor preference learning. Phenylephrine-induced learning occurred in the presence of propranolol to prevent indirect activation of beta-adrenoceptors. Alpha1-adrenoceptor mediation may represent a novel mechanism inducing learning or may increase cAMP in mitral cells via indirect activation of GABA(B) receptors. Neither the beta2-adrenoceptor agonist, salbutamol, nor the alpha2-adrenoceptor agonist, clonidine, induced learning.     

pCREB in the neonate rat olfactory bulb is selectively and transiently increased by odor preference-conditioned training

Early olfactory preference learning in rat pups occurs when novel odors are paired with tactile stimulation, for example stroking. cAMP-triggered phosphorylation of cAMP response element binding protein (pCREB) has been implicated as a mediator of learning and memory changes in various animals (Frank and Greenberg 1994). In the present study we investigate whether CREB is phosphorylated in response to conditioned olfactory training as might be predicted given the proposed role of the phosphorylated protein in learning. On postnatal day 6, pups were trained for 10 min using a standard conditioned olfactory learning paradigm in which a conditioned stimulus, Odor, was either used alone or paired with an unconditioned stimulus, Stroking (using a fine brush to stroke the pup). In some instances stroking only was used. The pups were sacrificed at 0, 10, 30, or 60 min after the training. Using Western blot analysis, we observed that the majority of olfactory bulbs in conditioned pups (Odor + Stroking) had a greater increase in pCREB activation at 10 min after training than pups given nonlearning training (Odor only or Stroking only). The phosphorylated protein levels were low at 0 min and at 60 min after training. This is in keeping with the slightly delayed and short-lived activation period for this protein. The localization of pCREB increases within the olfactory bulb as seen by immunocytochemistry. Naive pups were not exposed to odor or training. There was a significantly higher level of label in mitral cell nuclei within the dorsolateral quadrant of the bulb of pups undergoing odor-stroke pairing. No significant differences were observed among nonlearning groups (Naive, Odor only, or Stroking only) or among any training groups in the granule or periglomerular cells of the dorsolateral region. The localized changes in the nuclear protein are consistent with studies showing localized changes in the bulb in response to a learned familiar odor. The present study demonstrates that selective increases in pCREB occur as an early step following pairing procedures that normally lead to the development of long-term olfactory memories in rat pups. These results support the hypothesized link between pCREB and memory formation.     

Guilty but mentally ill: An alternative verdict

Despite opposition from professional groups such as the American Psychiatric Association and the American Bar Association, “Guilty But Mentally Ill” (GBMI) statutes now exist in at least 12 states and are being considered in others. This paper reviews the development of the GBMI alternative to the insanity defense from a historical perspective, focusing especially on the reasons for its development in Michigan, the first state to pass GBMI legislation over 9 years ago. Using the Michigan experience, the GBMI statute is reviewed in terms of its perceived purpose and its success in accomplishing that purpose. Then recommendations for future changes are made.     

“Stay in the Game”: Collecting Data on Symptom Improvement in Naturalistic Settings in Order to Increase Reimbursement Rates

An industrious approach to increasing reimbursement rates from third-party payers is reviewed. Balancing fidelity to treatment with real-world demands at a local hospital is discussed, as well as ways we were able to increase reimbursement within our own department. Data in naturalistic settings, though not always able to adhere to randomized controlled trials, offers evidence of improvement in symptoms. This reaction paper encourages other clinical programs to "stay in the game" of data collection while balancing treatment fidelity.     

解读曼殊五部曲

苏曼殊是清末民初萃集革命与刨作于一身的“奇人异僧”。从革命的角度说,他意志坚定,积极投身于孙中山领导的资产阶级民主革命,为推翻清朝统治和袁世凯帝制尽心竭力;从创作的角度说,他多才多艺,以风格独特的诗歌、小说、散、翻译、绘画树帜坛,赢得生前和身后无数读的击节和赞赏;从身份的角度说,他是个亦僧亦俗、亦侠亦儒的革命和艺家。他曾获得的桂冠大体停留在不大反映本质的“诗僧”、“情僧”、“风流和尚”、“革命和尚”等一类称号上,然而随着这位传奇的历史人物的“真面目”越来越清晰呈现于世,而不再继续充当人们揣测的对象。     

The role of functional and perceptual attributes: evidence from picture naming in dementia

We examined the performance of a group of people with moderately severe Alzheimer's type dementia on a naming task. We found that functional information plays an important role in determining naming performance on both living and non-living things. Perceptual information may play some role in naming living things. We also found some evidence that the semantic category to which an item belongs may also have some effect on naming performance. We argue that both the sensory-functional and domain-specific knowledge hypotheses may be correct: the brain is to some organized on taxonomic grounds, while the semantic representations of living and non-living things depend differentially on perceptual and functional information. These representations can be differentially disrupted by damage to modality-specific stores. At a moderate level of severity, dementia causes global damage that has the effect of disrupting both the localized taxonomic and the modality-specific stores. We discuss the nature of functional information.     

Multiple points of entry into a circular enclosure prevent place learning despite normal vestibular orientation and cue arrays: evidence for map resetting

This study identified sources of map orientation critical for successful spatial problem solving by rats of a plus maze embedded in water. Disorientation slowed, but it did not prevent acquisition of goal location. Use of a circular enclosure with multiple points of entry prevented reliable goal location. A single entry point enabled the rats to locate a fixed goal. A cue array within the enclosure was ineffective in providing orientation. These data suggest that stable map orientation can be derived from entry location when enclosure geometry is uniformative, but is not readily taken from cue arrays. They further suggest that map orientation is reset when rats enter an enclosure.