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91.
92.
Hao Z Jiang X Sharafeih R Shen S Hand AR Cone RE O'Rourke J 《Stress (Amsterdam, Netherlands)》2005,8(2):141-149
Recurrent stress is clinically associated with early onset hypertension and coronary artery disease. A mechanism linking emotion to pathogenic remodeling of the artery wall has not been identified. Stress stimulates acute regulated release of tissue plasminogen activator (t-PA) into the circulation, which is presently attributed to the vascular endothelium. Sympathetic neurons also synthesize t-PA and axonally transport it to the arterial smooth muscle. Unlike release by the endothelium, a stress-stimulated sympathetic discharge would potentially accelerate degradation of the wall matrix by plasmin. To assess whether sympathetic axons are the principal source of acute stress-induced arterial release of t-PA, we compared the output from small densely innervated and large sparsely innervated isolated artery segments before and after sympathetic stimulation, and after ablations. Following phenylephrine infusion densely-innervated microvessels in uveal eyecups were released over 60-fold greater amounts of active t-PA per milligram than the sparsely innervated aorta; and ten-fold more than carotid artery segments. Mesenteric artery release was 4.8-fold greater than release by the carotid artery. In vivo, uveal release of t-PA increased more than three-fold within one minute following superior cervical sympathetic ganglion electrical stimulation, and after phenylephrine, or nicotine infusions of the anterior chamber. Circulating levels of t-PA fell 70% following chemical sympathectomy. We propose that sympathetic nerves are the primary source of stress-induced release of t-PA into and from the densely innervated resistance arteries and arterioles, where dysregulated plasmin-induced proteolysis could damage the wall matrix. 相似文献
93.
The mediating role of self-efficacy in the development of entrepreneurial intentions 总被引:4,自引:0,他引:4
The purpose of this study was to investigate the mediating role of self-efficacy in the development of students' intentions to become entrepreneurs. The authors used structural equation modeling with a sample of 265 master of business administration students across 5 universities to test their hypotheses. The results showed that the effects of perceived learning from entrepreneurship-related courses, previous entrepreneurial experience, and risk propensity on entrepreneurial intentions were fully mediated by entrepreneurial self-efficacy. Contrary to expectations, gender was not mediated by self-efficacy but had a direct effect such that women reported lower entrepreneurial career intentions. The authors discuss practical implications and directions for future research. 相似文献
94.
表演式学习──表演理论对“最近发展区”的发展 总被引:1,自引:0,他引:1
美国当代心理学家、剧作家、表演理论的创始人弗雷德·纽曼(FredNewman)及其同事致力于在实践中发展维果茨基的理论,从表演的维度探讨了zpd的概念,并以此为核心提出了表演式学习的概念,以区别于在当今社会大行其道的工具性学习,即以获取知识和技能为目的的学习。表演理论通过对工具性学习的消极影响的批判及对表演式学习的倡导,在人的教育和发展方面提出了独到见解。 相似文献
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Wei He Po Hao Xu Huang Li-Rong Long Nathan J. Hiller Shao-Long Li 《Personnel Psychology》2020,73(1):199-225
Drawing on the componential model of creativity (Amabile), we examined how shared leadership and a formally appointed leader's transformational leadership jointly cultivate team creativity in two studies. We conducted an experiment with a sample of 109 undergraduate students (32 teams) enrolled in a business plan competition (Study 1) and a field survey based on multisource, time-lagged data collected from 251 full-time employees working on 64 research and development teams (Study 2). The results from both studies revealed that shared leadership enhanced team members’ individual creative self-efficacy and individual creativity, which in turn improved team creativity. Moreover, the results from Study 2 showed that a formally appointed leader's use of different transformational leadership behaviors had different impacts on individual and team creativity. Individual-focused transformational leadership strengthened the positive effect of shared leadership on team members’ average individual creativity, whereas group-focused transformational leadership facilitated the translation of teams with high average individual creativity into teams with high levels of team creativity. The theoretical and practical implications of the findings are discussed. 相似文献
97.
网络慈善众筹是从在线社区获得财力捐助的行为。本研究通过3个实验,考察在线社交平台上受益者面部表情与捐赠者–受益者关系对慈善众筹捐赠行为的影响。结果发现,快乐的面部表情对捐赠金额和分享意愿的影响总体上比悲伤更大;捐赠者–受益者共有的熟人关系比陌生人关系对捐赠金额与分享意愿的影响更大;面部表情与捐赠者–受益者关系对慈善众筹的捐赠金额存在交互作用,但对分享意愿没有显著性影响。结果表明,在线社交平台的慈善众筹捐赠行为更偏好有快乐面部表情的受益者,并且更多地受到间接的、社会交换预期微弱的熟人共有关系的影响。 相似文献
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99.
幽门螺杆菌感染与慢性胃炎、消化性溃疡、胃癌及胃黏膜相关性淋巴瘤有关.疫苗是防治幽门螺杆菌感染切实可行的方法.近年来新的防治和根除幽门螺杆菌感染的疫苗正在开发并取得了很大的进展.本综述结合本室研制Hp疫苗的研究基础,简要概述疫苗保护性抗原的筛选、黏膜免疫佐剂及接种途径、Hp疫苗的保护性免疫机制、Hp感染动物模型的建立及Hp疫苗人体临床试验等方面的研究进展. 相似文献
100.
有偿献血HIV感染者的情绪障碍 总被引:10,自引:0,他引:10
考察有偿献血HIV感染者的情绪状况,探讨他们面临的艾滋病压力和对感染HIV的认知评价对其情绪的影响。方法:采用Beck抑郁量表、焦虑自评量表、艾滋病压力量表、认知评价量表作为测查工具,测查了185名有偿献血HIV感染者,并收集了人口学资料、症状资料和其它信息。结果:(1)92%的有偿献血HIV感染者有中、重度抑郁障碍,他们的焦虑程度高于神经衰弱者和焦虑症者;(2)艾滋病压力不仅通过认知评价而且会直接对情绪障碍产生影响;(3)认知评价在艾滋病压力和情绪障碍之间起部分中介作用。结论:有偿献血HIV感染者抑郁、焦虑情绪障碍严重,艾滋病压力和认知评价对情绪障碍的产生都有直接或间接的影响 相似文献