幽门螺杆菌感染的免疫防治

幽门螺杆菌感染与慢性胃炎、消化性溃疡、胃癌及胃黏膜相关性淋巴瘤有关.疫苗是防治幽门螺杆菌感染切实可行的方法.近年来新的防治和根除幽门螺杆菌感染的疫苗正在开发并取得了很大的进展.本综述结合本室研制Hp疫苗的研究基础,简要概述疫苗保护性抗原的筛选、黏膜免疫佐剂及接种途径、Hp疫苗的保护性免疫机制、Hp感染动物模型的建立及Hp疫苗人体临床试验等方面的研究进展.     

有偿献血HIV感染者的情绪障碍

考察有偿献血HIV感染者的情绪状况,探讨他们面临的艾滋病压力和对感染HIV的认知评价对其情绪的影响。方法：采用Beck抑郁量表、焦虑自评量表、艾滋病压力量表、认知评价量表作为测查工具,测查了185名有偿献血HIV感染者,并收集了人口学资料、症状资料和其它信息。结果：（1）92%的有偿献血HIV感染者有中、重度抑郁障碍,他们的焦虑程度高于神经衰弱者和焦虑症者;（2）艾滋病压力不仅通过认知评价而且会直接对情绪障碍产生影响;（3）认知评价在艾滋病压力和情绪障碍之间起部分中介作用。结论：有偿献血HIV感染者抑郁、焦虑情绪障碍严重,艾滋病压力和认知评价对情绪障碍的产生都有直接或间接的影响     

汉语图片命名中获得年龄的作用

不同语种的研究都发现获得年龄是影响图片命名和词汇命名的重要因素。该研究对汉语图片命名中获得年龄的作用进行了初步探讨。研究分为两部分,第一部分让20名大学生对187幅选自Snodgrass和Vanderwart图片集的线条画的名称的获得年龄进行了评定;第二部分以该187幅图片为刺激,30名大学生被试对图片进行命名反应。以命名反应时为因变量,采用多重回归分析,发现除了名称一致性和概念熟悉性,获得年龄是图片命名反应时的主要预测指标,并没有发现词频的效应。文章对此结果进行了讨论。     

耻感与道德体系

在主张德治的儒家和主张法治的法家两大道德哲学的历史传统及其所代表的个体道德和社会伦理的两大道德哲学的逻辑体系中,耻感都是道德哲学体系的原素和原色.耻感的伦理根源和伦理动力是个体"成为一个人"的向伦理实体和人的公共本质回归的精神运动.耻感的道德本性是作为"主观意志的法"的道德自由,因而它的更深刻的本质不是他律而是自律,不是制裁而是激励,是推动人们在道德上自强不息、止于至善的精神力量.     

A technique for simulating visual field losses in virtual environments to study human navigation

The following paper describes a new technique for simulating peripheral field losses in virtual environments to study the roles of the central and peripheral visual fields during navigation. Based on Geisler and Perry's (2002) gaze-contingent multiresolution display concept, the technique extends their methodology to work with three-dimensional images that are both transformed and rendered in real time by a computer graphics system. In order to assess the usefulness of this method for studying visual field losses, an experiment was run in which seven participants were required to walk to a target tree in a virtual forest as quickly and efficiently as possible while artificial head and eye-based delays were systematically introduced. Bilinear fits were applied to the mean trial times in order to assess at what delay lengths breaks in performance could be observed. Results suggest that breaks occur beyond the current delays inherent in the system. Increases in trial times across all delays tested were also observed when simulated peripheral field losses were applied compared to full FOV conditions. Possible applications and limitations of the system are discussed. The source code needed to program visual field losses can be found at lions.med.jhu.edu/archive/turanolab/Simulated_Visual_Field_Loss_Code.html.     

分配不公正下的退缩行为：程序公正和互动公正的影响

以160名中学教师为被试,采用2×2的完全随机设计,以模拟故事（scenarios）的方法呈现刺激,研究了在职称评定中分配不公正的前提下,程序公正/不公正,互动公正/不公正对教师的退缩行为（消极怠工、拒绝帮助、离职、对校长的消极态度）的影响。结果表明,在分配不公正条件下：（1）程序公正、互动公正均影响教师的消极怠工程度;（2）程序公正、互动公正均影响教师的拒绝帮助行为程度,而且交互作用显著;（3）互动公正影响教师对上司的消极态度,程序公正无显著影响;（4）程序公正和互动公正对离职意愿影响均不显著     

家长式领导与组织公正感的关系

以428名企事业单位员工为调查对象,采用问卷法,探讨了家长式领导与组织公正感的关系,结果表明：（1）仁慈领导对组织公正感各维度有显著的积极影响;德行领导对组织公正感各维度有显著的积极影响;权威领导对领导公正有显著的消极影响;（2）在分配公正、程序公正上,德行与权威领导有显著负交互效应;在领导公正、领导解释上,仁慈与权威领导有显著负交互效应。最后,对研究的理论和实践意义作了探讨,并提出了未来的研究方向     

Statistical Learning of Unfamiliar Sounds as Trajectories Through a Perceptual Similarity Space

In typical statistical learning studies, researchers define sequences in terms of the probability of the next item in the sequence given the current item (or items), and they show that high probability sequences are treated as more familiar than low probability sequences. Existing accounts of these phenomena all assume that participants represent statistical regularities more or less as they are defined by the experimenters—as sequential probabilities of symbols in a string. Here we offer an alternative, or possibly supplementary, hypothesis. Specifically, rather than identifying or labeling individual stimuli discretely in order to predict the next item in a sequence, we need only assume that the participant is able to represent the stimuli as evincing particular similarity relations to one another, with sequences represented as trajectories through this similarity space. We present experiments in which this hypothesis makes sharply different predictions from hypotheses based on the assumption that sequences are learned over discrete, labeled stimuli. We also present a series of simulation models that encode stimuli as positions in a continuous two‐dimensional space, and predict the next location from the current location. Although no model captures all of the data presented here, the results of three critical experiments are more consistent with the view that participants represent trajectories through similarity space rather than sequences of discrete labels under particular conditions.     

临床医学教育中的医学哲学

医学哲学是现代医学教育中的重要组成部分,医学科学必须与医学哲学相结合才是未来医学教育的发展方向。在以岗位胜任能力为导向的医学教育转型中,培养医学生的哲学思维无疑是其重要环节之一。为适应全球卫生事业的迅猛发展,医学教育务必在临床思维上进行整合。本文从培养合格医学毕业生的角度出发,阐述了医学与哲学的关系、医学教育中的哲学地位及哲学在临床医学教育中的具体应用。旨在提高医学生的哲学理念,促进现代医学教育的转型发展。     

独立预测作用,还是基础性影响？——价值观对集体行动的影响机制

为阐明价值观在集体行动参与中的地位和影响机制,研究者以利比亚事件为背景,针对现实和网络场域中不同程度的4类集体行动倾向,在天津市957名大学生中进行问卷调查研究,结果发现：价值观显著增加了低成本集体行动倾向解释率,并调节着情绪、工具性动机和社会认同对集体行动倾向的影响;中国人进行集体行动决策时具有集体主义理性计算特征;不同场域和程度的集体行动有其各自规律.结论：价值观在集体行动参与决策中是一种与社会认同类似的基础性变量.