Brain responses to lexical-semantic priming in children at-risk for dyslexia

Deviances in early event-related potential (ERP) components reflecting auditory and phonological processing are well-documented in children at familial risk for dyslexia. However, little is known about brain responses which index processing in other linguistic domains such as lexicon, semantics and syntax in this group. The present study investigated effects of lexical-semantic priming in 20- and 24-month-olds at-risk for dyslexia and typically developing controls in two ERP experiments. In both experiments an early component assumed to reflect facilitated lexical processing for primed words was enhanced in the at-risk group compared to the control group. Moreover, an N400-like response which was prominent in the control group was attenuated or absent in at-risk children. Results suggest that deficiencies in young children at-risk for dyslexia are not restricted to perceptual and lower-level phonological abilities, but also affect higher order linguistic skills such as lexical and semantic processing.     

Developmental dyslexia and widespread activation across the cerebellar hemispheres

Developmental dyslexia is the most common learning disability in school-aged children with an estimated incidence of five to ten percent. The cause and pathophysiological substrate of this developmental disorder is unclear. Recently, a possible involvement of the cerebellum in the pathogenesis of dyslexia has been postulated. In this study, 15 dyslexic children and 7 age-matched control subjects were investigated by means of functional neuroimaging (fMRI) using a noun-verb association paradigm. Comparison of activation patterns between dyslexic and control subjects revealed distinct and significant differences in cerebral and cerebellar activation. Control subjects showed bilaterally well-defined and focal activation patterns in the frontal and parietal lobes and the posterior regions of the cerebellar hemispheres. The dyslexic children, however, presented widespread and diffuse activations on the cerebral and cerebellar level. Cerebral activations were found in frontal, parietal, temporal and occipital regions. Activations in the cerebellum were found predominantly in the cerebellar cortex, including Crus I, Crus II, hemispheric lobule VI, VII and vermal lobules I, II, III, IV and VII. This preliminary study is the first to reveal a significant difference in cerebellar functioning between dyslexic children and controls during a semantic association task. As a result, we propose a new hypothesis regarding the pathophysiological mechanisms of developmental dyslexia. Given the sites of activation in the cerebellum in the dyslexic group, a defect of the intra-cerebellar distribution of activity is suspected, suggesting a disorder of the processing or transfer of information within the cerebellar cortex.     

Kuhn's Account Of Family Resemblance: A Solution To The Problem Of Wide-Open Texture

It is a commonly raised argument against thefamily resemblance account of concepts that, on thisaccount, there is no limit to a concept's extension.An account of family resemblance which attempts toprovide a solution to this problem by including bothsimilarity among instances and dissimilarity tonon-instances has been developed by the philosopher ofscience Thomas Kuhn. Similar solutions have beenhinted at in the literature on family resemblanceconcepts, but the solution has never received adetailed investigation. I shall provide areconstruction of Kuhn's theory and argue that hissolution necessitates a developmental perspective withbuilds on both the transmission of taxonomies betweengenerations and a progressive development throughhistory.     

Typology,the eight-function model,and archetypal complexes

This clinical presentation shows what insights a typology-conscious analysis of clients and their families may lead to and points out what is added by applying John Beebe’s eight-function, eight-archetype model. To reflect on the inner balance between archetypal complexes in the eight-function structure that holds our psyche, the author invites clients to do a typological analysis, including an analysis of their archetypal patterns, which may, itself, provoke anxiety. This article includes a presentation of ideas and experiences sparked when confronting these complexes in clinical work. Clients are introduced to six stages of coping with stress that may allow them to be more conscious of their complexes when triggered. These stages are Faint, Freeze, Flight, Fidget, Fight, and Flow. To identify whether the stress is physiological, emotional, or intellectual, the idea of the Triune Brain is introduced. The therapeutic work may lead to redemption from opposites, which is an ethical task.     

Effect of self-discrepancy on specificity of autobiographical memory retrieval

Research using a cue word paradigm has consistently shown that depression, in both adults and adolescents, is associated with difficulties in retrieving specific autobiographical memories. Inspired by previous work stating that depressed feelings are related to a perceived discrepancy between attributes of the actual and the ideal self, the present study aimed to investigate the hypothesis that cues bringing discrepancies between the actual and ideal selves to the foreground might promote or facilitate the recall of overgeneral (instead of specific) autobiographical memories. In two studies adolescents provided autobiographical memories in response to 10 high-discrepant and 10 low-discrepant words. As predicted, results in both studies showed an effect of cue word discrepancy on the specificity of autobiographical memories such that participants retrieved a smaller proportion of specific and a greater proportion of overgeneral memories in response to high-discrepant words as compared to low-discrepant words. The findings are discussed in terms of the self-memory system (SMS) as a conceptual framework of autobiographical memory (Conway & Pleydell-Pearce, 2000).     

Neuropattern: a new translational tool to detect and treat stress pathology. II. The Teltow study

The present study was designed to test the clinical utility of Neuropattern (NP), a newly developed translational diagnostic tool. NP consists of biological and psychological measures that facilitate the identification of functional changes (called "neuropatterns") in patients with stress-related health problems. In this prospective, randomized control trial, we expected NP to improve therapeutic efficacy, as compared with the usual treatment. NP was applied to 101 in-patients suffering from various mental disorders (mainly depression, anxiety disorders, and adjustment disorders), and scoring high on the Symptom Checklist-90-R (SCL-90-R) somatization scale. The patients (73% females, mean?±?standard deviation age 46?±?9.03 years) were randomly assigned to two groups: in the experimental group (n?=?51), physicians received results from NP diagnostics, while in the control group (n?=?50), this information was not available until discharge from the hospital. Improvements of symptoms in consequence of treatment were monitored by two self-rating scales, the SCL-90-R and Short Form-12 health survey, and a physician's clinical global rating (Beeintr?chtigungs-Schwere Score). There was a significantly greater improvement in the experimental group in the self-rating assessments on symptom severity (p?=?0.03) and quality of life (p?=?0.05), but not in the observer rating of emotional, physical, and social-communicative functioning (p?=?0.13). Treatment efficacy in patients can be improved by providing the attendant physician and the patient with diagnostic information and treatment recommendations by NP. The role of concrete mediators of treatment efficacy awaits further research.     

Defense mechanisms: An approach from the perspective of personal construct psychology

The psychoanalytic concept of defense mechanisms was theoretically and empirically approached from the perspective of personal construct psychology, in an attempt to investigate its cognitive components. Thirty neurotic clients of the Psychotherapeutic Center in Stuttgart, Federal Republic of Germany, were investigated by means of the Questionnaire for Defense Categories (Ehlers & Peter, 1989) and the Repertory Grid Test (Kelly, 1955). Tight construing, extremity of emotional evaluation, construal of the symptom as having positive implications, and construed similarity between certain aspects of the self were observed in clients who frequently used the defense mechanisms denial, rationalization, and turning against the object.     

Negotiating ending: A qualitative study of the process of ending psychotherapy

Objectives: When psychotherapy is open-ended, the question of termination is a matter for negotiation. A model based on both content and the process of ending may explain how ‘good enough’ psychotherapies can be brought to ‘good enough’ endings.

Design: Twelve processes of ending were explored through a combination of audio recordings made during therapy sessions and post-therapy interviews with clients and therapists. Therapies had been tailored to the needs of the clients and were based on a broad spectrum of theoretical affiliations.

Methods: A procedure for systematic text condensation was used on a case-by-case basis. Issues surrounding the initiation and negotiation of ending were pointed out in each case and were then compared across cases.

Results: The initiation of ending and exchanges concerned with when and how to end therapy unfolded as a concerted process because both parties seemed to be aware that the theme of ending contained a potential challenge to the alliance. Dual affect regulation, implicit communication and a future-oriented perspective were important features. Structural elements such as schedule changes and temporary breaks served several psychological functions. Therapies seemed to reach ‘good enough’ endings when the client and therapist joined in their efforts to resolve basic ambivalences embedded in the decision to terminate contact with the affirmation of a continuing emotional bond.