Genetic Counseling in Southern Iran: Consanguinity and Reason for Referral

Population based genetic counseling that promotes public health goals is an appropriate health care service. The genetic counseling center in Shiraz, southern Iran serves most of the clients in the region. During a 4-year period, 2,686 couples presented for genetic counseling. Data files revealed that 85% had consanguineous relationships (1.5% double first cousin, 74% first cousin, 8% second cousin, 1.5% beyond second cousin). Most prevalent reasons for referral were premarital counseling (80%), with 89% consanguinity, followed by preconception (12%), postnatal (7%), and prenatal counseling (1%). The most common abnormalities in probands or relatives were intellectual and developmental disabilities, hearing loss/impairment, and neuromuscular dystrophies. Family history of medical problem(s) and/or consanguinity was the main indication for referral in nearly every family. Premarital consanguinity poses unique challenges and opportunities. There is considerable opportunity for genetic counseling and education for couples in this population. The tradition of consanguinity, which is likely to persist in Iran, requires multidisciplinary agreement regarding the appropriate process of genetic counseling. Effective genetic counseling in Iran hinges on inclusion of data from genetic counseling services in national genomic and epidemiologic research programs.     

Reduced specificity of emotional autobiographical memories following self-regulation depletion

The present study used a Color Stroop task, involving naming the ink colors of incongruous color words, to deplete self-regulation resources prior to retrieving a series of autobiographical memories to emotional and neutral cue words--the Autobiographical Memory Test (AMT). Control participants either read color words written in black ink or performed no task prior to the AMT. Difficulty accessing specific memories on the AMT has been shown to index key aspects of the onset and maintenance of depression and other emotional disorders. Our hypothesis that depleted participants would retrieve fewer specific memories to cues on the AMT relative to controls was supported, even when levels of depressed and anxious mood, an index of clinical depression, posttraumatic stress, and verbal intelligence were covaried. The results indicate that self-regulation depletion via a neutral, unrelated task can impact on emotion-related autobiographical memory processes that have been shown to be dysfunctional in emotionally disordered populations.     

Intrahippocampal insulin improves memory in a passive-avoidance task in male wistar rats

The main impacts of insulin favor the peripheral organs. Although it functions as a neuropeptide, insulin possesses also some central effects. The aim of this study was to determine the effect of intrahippocampal infusion of insulin on passive avoidance learning in healthy male rats. Thirty male wistar rats were divided into three groups (n=10 each). The experimental group had posttraining insulin infusion into the CA1 region of dorsal hippocampus, after which they were compared with sham (saline) and control (intact) groups. Insulin treated animals had greater latency to enter the dark compartment in compare with saline treated (p=0.023) or control groups (p=0.017). Upon our results, we concluded that intrahippocampal injections of insulin may enhance memory for a simple learning task which supports the concept that insulin possibly plays an endogenous role in memory formation.     

Charity, Supervenience, and Skepticism

In a number of articles Donald Davidson has argued that the charitable nature of his method of radical interpretation rules out the possibility of massive error and thus refutes Cartesian skepticism. The diversity of such arguments and the suggestions that are all being made under the name of the principle of charity have prompted a large body of conflicting responses, adding only to the obscurity of the issues that are generally associated with the question of skepticism. In this paper I propose to consider the debate in a new light by reconstruing the principle of charity as a supervenience constraint on belief attribution. This would help explain some of the puzzling features of Davidson's arguments, like the idea of an omniscient interpreter, and the ensuing commentaries. Having provided an analysis of the limitations of Davidson's arguments, I shall then suggest an alternative explanation of the purported necessity of the principle of charity. Finally, having construed the principle of charity as a supervenience constraint, I shall examine what consequences this construal has for the logical status of the principle itself and its alleged epistemic potentials.     

Motivations for childbearing and fertility behavior among urban and rural families of Iran

A sample of 384 husbands and wives were randomly selected and interviewed to investigate the implication of fertility norms and motivations for childbearing on fertility and family planning behavior among Iranian families in urban and rural areas of Iran, after the Islamic Revolution of 1979. The term "fertility behavior" refers to actual family size, which is defined as number of children the respondent has living at the time of the interview. "Family planning behavior" refers to the duration of time that the subject has used any birth control method(s). Rural families demonstrated larger actual and ideal family sizes than urban families. The rural sample had a median actual family size of 3.5 children and a median ideal family size of 4.7 children. For the urban sample these figures were 2.2 and 2.3, respectively. The median number of years married was 12.33 for rural and 13.91 for urban respondents. Urban respondents tended to emphasize the psychological and emotional benefits and liabilities associated with having children while rural respondents tended to emphasize both economic and security related motivations. Both groups endorsed infant mortality as a motivation for having more children. Male and female respondents were remarkably similar in their endorsed motivations. There was a significant positive correlation between desired and ideal family size. The correlations among ideal/desired family size and practicing birth control methods were the same and significant at the .001 level. The relationship between motivations for childbearing and years of practicing birth control methods was also significant at the .001 level. Stepwise regression analyses were performed to examine the important predictors of fertility and family planning behavior. For both actual family size and years on birth control, males and females were very similar in terms of predictor importance. Those respondents with less education and large ideal family size tended to have larger actual family size. Location (urban/rural) and parents, family size was weighted much more heavily for males than for females. Those respondents with greater education and who lived in an urban areas tended to have used birth control for longer periods of time. Ideal family size did not contribute significantly to this regression. Parents' family size and motivations for childbearing made marginal contributions to regressions on either dependent variable.     

Bilingualism Is Associated with a Delayed Onset of Dementia but Not with a Lower Risk of Developing it: a Systematic Review with Meta-Analyses

Neuropsychology Review - Some studies have linked bilingualism with a later onset of dementia, Alzheimer’s disease (AD), and mild cognitive impairment (MCI). Not all studies have observed...     

Organisational interventions to improve employees' health and wellbeing: A realist synthesis

Although organisational interventions have shown promising results in improving employees' health and wellbeing, reviews of the effectiveness of such interventions conclude results are inconsistent. Realist synthesis is considered an appropriate method of literature review to improve the consistency of empirical evidence by developing generalisable statements of ‘what works for whom in which circumstances’. In this article, to identify and synthesise existing evidence from the empirical studies of organisational interventions, we conducted a realist synthesis according to the RAMESES publication standards. We reviewed 28 articles. Six realist programme theories were developed that explain how different mechanisms of organisational interventions may bring about different outcomes in different contexts. These realist programme theories are based on the process mechanisms of implementation adherence, communication, employees' participation, senior management support, middle management support and external consultants/researchers support. This realist synthesis enhances the understanding of how organisational interventions may improve employees' health and wellbeing, in which contexts, and for which group of employees. As such, it makes an important potential contribution to designing, implementing and evaluating future organisational interventions.