溶栓后PCI,从不行到可行

再灌注治疗STEMI的方法有直接PCI和溶栓。我国各地医疗条件差别较大,只有12%的STEMI患者能够及时接受直接PCI,超过半数的患者仍行溶栓治疗,故溶栓在我国再灌注策略中占有重要地位。虽然溶栓后即刻PCI即易化PCI被证实不如直接PCI,但溶栓并非STEMI治疗的终点。目前国外循证证据显示溶栓后早期转运PCI优于溶栓失败后再转运行补救PCI,值得我国借鉴学习。     

Ventral lateral geniculate input to the medial pons is necessary for visual eyeblink conditioning in rats

The conditioned stimulus (CS) pathway that is necessary for visual delay eyeblink conditioning was investigated in the current study. Rats were initially given eyeblink conditioning with stimulation of the ventral nucleus of the lateral geniculate (LGNv) as the CS followed by conditioning with light and tone CSs in separate training phases. Muscimol was infused into the medial pontine nuclei (MPN) after each training phase to examine conditioned response (CR) retention to each CS. The spread of muscimol infusions targeting the MPN was examined with fluorescent muscimol. Muscimol infusions into the MPN resulted in a severe impairment in retention of CRs with the LGNv stimulation and light CSs. A less severe impairment was observed with the tone CS. The results suggest that CS information from the LGNv and light CSs is relayed to the cerebellum through the MPN. Retrograde tracing with fluoro-gold (FG) showed that the LGNv and nucleus of the optic tract have ipsilateral projections to the MPN. Unilateral inputs to the MPN from the LGNv and nucleus of the optic tract may be part of the visual CS pathway that is necessary for visual eyeblink conditioning.The neural substrates of associative motor learning have been studied extensively using eyeblink conditioning (Christian and Thompson 2003; Thompson 2005). Eyeblink conditioning is typically established by pairing a tone or light conditioned stimulus (CS) with an unconditioned stimulus (US) that elicits the eyeblink reflex. An eyeblink conditioned response (CR) emerges over the course of paired training, and the peak of eyelid closure occurs at the onset time of the US. Results from experiments using temporary lesions of the cerebellar deep nuclei or cerebellar cortex indicate that the anterior interpositus nucleus and cerebellar cortex are necessary for acquisition, expression, and extinction of eyeblink conditioning (Krupa et al. 1993; Hardiman et al. 1996; Krupa and Thompson 1997; Garcia and Mauk 1998; Medina et al. 2001; Bao et al. 2002; Freeman et al. 2005a). Blocking cerebellar output with inactivation of the superior cerebellar peduncle, red nucleus, or brainstem motor nuclei selectively blocks CR expression but not acquisition, providing further evidence that learning occurs in the cerebellum (Chapman et al. 1990; Krupa et al. 1993, 1996; Krupa and Thompson 1995).Sensory stimuli from every modality are sent to the pontine nuclei (PN), which receive projections from the lower brainstem, thalamus, and cerebral cortex (Glickstein et al. 1980; Brodal 1981; Mihailoff et al. 1989; Schmahmann and Pandya 1989; Wells et al. 1989; Knowlton et al. 1993; Campolattaro et al. 2007). Neurons in the PN project CS information to the cerebellum via mossy fibers in the middle cerebellar peduncle that synapse on granule cells in the cerebellar cortex and on neurons in the interpositus nucleus (Bloedel and Courville 1981; Brodal 1981; Steinmetz and Sengelaub 1992; Mihailoff 1993). Lesions of the middle cerebellar peduncle impair eyeblink conditioning with auditory, somatosensory, and visual CSs (Lewis et al. 1987). Bilateral electrolytic lesions of the dorsolateral and lateral pontine nuclei (LPN) block retention of CRs to an auditory CS but have no effect on light-elicited CRs (Steinmetz et al. 1987). Inactivation of the contralateral LPN blocks CRs to a tone CS but not to lateral reticular nucleus stimulation in rabbits (Bao et al. 2000). Moreover, stimulation of the LPN or middle cerebellar peduncle is a sufficient CS for eyeblink conditioning (Steinmetz et al. 1986, 1987; Tracy et al. 1998; Bao et al. 2000; Freeman and Rabinak 2004; Freeman et al. 2005b; Campolattaro and Freeman 2008). The findings from the lesion, inactivation, and stimulation studies provide evidence that the PN is the proximal part of the CS pathway for cerebellar learning. These studies also indicate that the LPN is the primary source of auditory CS input to the cerebellum.Only a few studies have examined the visual CS pathway necessary for eyeblink conditioning. The dorsal and ventral divisions of the lateral geniculate nucleus of the thalamus (LGNd, LGNv), pretectal nuclei, visual cortex (VCTX), and superior colliculus (SC) comprise a hypothesized parallel visual CS pathway for eyeblink conditioning (Koutalidis et al. 1988). Combined lesions of all of these visual areas completely block acquisition, lesions of two visual areas produce a partial impairment, and lesions in one visual area do not impair CR acquisition (Koutalidis et al. 1988). Stimulation of the VCTX, SC, and LGNv support eyeblink conditioning, and each of these structures has a direct unilateral projection to the PN that could be important for eyeblink conditioning (Halverson et al. 2009). The lesion and stimulation studies provide evidence that structures in the hypothesized visual CS pathway are independently capable of supporting conditioning. An important aspect of the visual CS pathway proposed in the Koutalidis et al. (1988) study is distributed projections of each visual area to different regions of the PN. The important projections were hypothesized to be from the VCTX to the rostral portion of the PN, from both the SC and pretectal nuclei to the dorsolateral PN, and the LGNv projection to the medial pontine nuclei (MPN) (Koutalidis et al. 1988). Lesions of the VCTX were substituted for LGN lesions in the Koutalidis et al. (1988) study due to technical problems with animal survival. The LGNv projection to the MPN was therefore not examined in their combined lesion group. Stimulation of the anterior pretectal nucleus is not a sufficient CS to support eyeblink conditioning (Campolattaro et al. 2007). The direct PN projection from the VCTX is not necessary for CR retention to a light CS, as lesions do not prevent eyeblink conditioning to a light CS in dogs or monkeys (Hilgard and Marquis 1935, 1936). Moreover, lesions of the entire cerebral cortex do not prevent acquisition or retention of delay eyeblink conditioning to a tone or light CS in rabbits (Oakley and Russell 1972, 1977). The LGNv and SC, therefore, are likely sources of visual input to the PN that is necessary for eyeblink conditioning.The current experiment investigated whether information from the LGNv and a visual CS (light) share similar inputs into the MPN and whether those inputs are different from an auditory CS. The visual projections to the MPN were also investigated with the retrograde tracer fluoro-gold (FG) to identify structures that may be involved with the relay of CS information during eyeblink conditioning. In the conditioning experiment, rats received three phases of training, with each phase consisting of three acquisition sessions followed by a muscimol infusion into the MPN, and then a saline recovery session. Each rat received unilateral stimulation of the LGNv (contralateral to the trained eye) during phase 1 of training followed by either a tone or light CS in phases 2 and 3 (order of stimulus presentation was counterbalanced). One group received LGNv stimulation in phase 1 followed by a light CS in phase 2, and a tone CS in phase 3 (SLT). The other group received the tone CS in phase 2, and light CS in phase 3 (STL).     

医科大学生优秀学业表现的人格心理学分析及相关性研究

目的:探讨医科大学生优秀学业表现的特征人格以及学业成绩性别差异的人格心理学原因。方法:以卡特尔16PF个性测验为测试工具,应用Spearman相关系数对医科大学生人格特质与学业成绩综合得分进行相关分析。结果:医科大学男女生的开放性分别为5.80±0.89和4.47±1.41,差别有统计学显著性(p0.001)。大学生学业成绩的高低和大学生的自律性和稳定性的相关系数分别为0.271和0.263。结论:医科男女大学生学业成绩差异主要与其开放性大小有关,大学生在校期间学业成绩分值的高低与人格特质中的自律性和稳定性大小成正比,提示加强大学生自律性和稳定性的训练有助于塑造大学生良好的人格特质。     

信息外部表征形式对初中生学习决策框架效应的影响

333名初中生被分配到基于描述表征的两种条件下,分别对获得框架与损失框架下的风险回避类与风险寻求类学习时间选项进行抉择,以探讨信息外部表征对学习决策框架效应的影响.结果表明:1)在基于描述表征的条件下,学习决策领域中存在框架效应,但有其领域特殊性,被试在获得框架中无明显决策偏向,但在损失框架中的决策明显偏向风险寻求.2)在基于经验表征的条件下,学习决策不存在框架效应.无论是在获得框架还是损失框架中的学习决策均不存在明显的偏向.     

时间贴现的分段性

以延迟和相对延迟时间贴现的实验范式, 用选择法、匹配法确定价值主观相等点, 探讨时间贴现的分段性。三个实验和一个问卷调查发现, 时间贴现具有分段性。被试的时间贴现有三次显著变化, 表现为三个时段时间贴现心理状态的不同: 从现在到未来2周内规避损失、偏好风险、愿意短期等待, 从未来2周起直到未来10年采取非补偿性策略、需求与风险并重、愿意长期等待, 和从未来10年起直到未来50年规避风险、聊胜于无、不愿意等待。     

元刻板印象及其对群际关系的作用

元刻板印象是指个体关于外群体成员对其所属群体(内群体)所持刻板印象的信念。作为一种群际元知觉, 元刻板印象的内容和效价可以在一定程度上反映群际关系。近些年, 越来越多的研究表明元刻板印象是影响群际关系的更加重要的变量。相对于刻板印象, 元刻板印象的激活更加复杂, 激活的元刻板印象会引发一系列的情绪、认知和行为效应。未来研究应关注元刻板印象作用于群际关系的心理机制, 并进一步探讨通过元刻板印象改善群际关系的策略, 开展针对于我国不同群体的本土化研究。     

绩效薪酬对员工突破性创造力和渐进性创造力的影响

研究分别从认知评价理论和习得性努力理论视角考察了绩效薪酬对员工突破性创造力和渐进性创造力的影响及其作用机制, 并检验了变革型领导和交易型领导对上述两条路径的调节效应。基于24家企业的364对上下级匹配数据的研究结果表明：绩效薪酬对内在动机和突破性创造力没有显著的影响, 对外在动机和渐进性创造力有显著的正向影响。变革型领导调节绩效薪酬与突破性创造力的关系：高变革领导情境下, 绩效薪酬通过正向影响内在动机间接对突破性创造力产生正向影响; 低变革领导情境下, 绩效薪酬通过负向影响内在动机间接对突破性创造力产生负向影响。交易型领导调节绩效薪酬与渐进性创造力的关系：交易型领导通过强化绩效薪酬对外在动机的影响进而放大了绩效薪酬对渐进性创造力的正向效应。针对上述结果, 讨论了本文的理论与实践意义。     

心理距离对跨期选择和风险选择的影响

通过考察时间距离、社会距离和概率距离对跨期选择和风险选择的影响, 探究跨期选择和风险选择心理过程的相似性, 并检验不同心理距离影响决策的相似性。结果发现, 无论是时间距离(实验1)、社会距离(实验2)、还是概率距离(实验3), 心理距离越远, 被试在跨期选择中越倾向于延迟选项, 在风险选择中越倾向于风险选项。研究认为, 在跨期选择和风险选择中, 选项的表征结构和选项整体评价时不同选项特征的相对权重具有相似性。随着心理距离增加, 与高识解相联系的金额特征的相对权重增加, 与低识解相联系的时间和概率特征的相对权重降低, 这使得被试更倾向于选择金额较大的延迟和风险选项。同时, 研究发现三类心理距离对两类决策有相似影响, 进一步验证了不同心理距离的本质相似性。     

情绪对内隐态度和外显态度联结的调节作用

不同的情绪在内隐态度与外显态度表现过程中塑造着不同的心理环境, 调节内隐态度和外显态度的一致性。正性情绪增加了内隐态度与外显态度的联结, 然而负性情绪对内隐态度与外显态度联结的调节作用表现并不一致。单一考虑情绪的正负效价不足以解释具体情绪影响的差异性, 情绪的确定性、情绪与直觉信任的交互作用均会对内隐态度与外显态度的联结产生影响。理论方面, 联结性-推理性评价模型及情绪-信息模型对情绪调节内隐态度与外显态度联结的内在机制进行了解释。未来研究可进一步探索特定情绪对内隐态度与外显态度联结的调节作用, 并考察情绪是否会对内隐刻板印象与外显刻板印象的联结产生调节作用, 以及采用认知神经科学技术揭示情绪调节内隐态度与外显态度联结的神经机制。     

文本阅读中时间信息加工特点及二阶段模型的建构

时间信息的加工一直是当代阅读心理研究的热点。以往研究对时间信息表征的性质、维度特征、提取机制等问题存在诸多争论, 主要表现为强印象假设与场景理论的冲突。我们认为, 文本阅读中时间信息的加工包括两个阶段：加工时间词以及低水平的更新情景模型阶段和通达与整合先前信息阶段, 强印象假设和场景理论争论的实质在于前者解释的是加工的第一个阶段, 而后者解释的是加工的第二个阶段, 因此, 总是难以调和。本项目首先在更高的理论层面上将二者加以整合, 然后采用经典的认知心理学研究方法与现代的眼动研究技术相结合的方法, 通过对文本阅读中时间信息表征性质、加工的维度特征、提取过程的激活与抑制特征等问题的探讨, 为本项目提出的时间信息加工的二阶段模型提供行为实验与眼动实验证据, 从而解决该领域中强印象假设与场景理论的长期争论。本项目的理论构想与研究技术对文本阅读其他问题的探讨具有重要的方法论意义。