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Opposing effects on muscarinic acetylcholine receptors in the piriform cortex of odor-trained rats
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Saar D Dadon M Leibovich M Sharabani H Grossman Y Heldman E 《Learning & memory (Cold Spring Harbor, N.Y.)》2007,14(3):224-228
We combined pharmacological studies and electrophysiological recordings to investigate modifications in muscarinic acetylcholine (ACh) receptors (mAChR) in the rat olfactory (piriform) cortex, following odor-discrimination rule learning. Rats were trained to discriminate between positive and negative cues in pairs of odors, until they reached a phase of high capability to learn unfamiliar odors, using the same paradigm (“rule learning”). It has been reported that at 1–3 d after the acquisition of odor-discrimination rule learning, pyramidal neurons in the rat piriform cortex show enhanced excitability, due to a reduction in the spike-activated potassium current IAHP, which is modulated by ACh. Further, ACh and its analog, carbachol (CCh), lost the ability to reduce the IAHP in neurons from trained rats. Here we show that the reduced sensitivity to CCh in the piriform cortex results from a decrease in the number of mAChRs, as well as a reduction in the affinity of the receptors to CCh. Also, it has been reported that 3–8 d after the acquisition of odor-discrimination rule learning, synaptic transmission in the piriform cortex is enhanced, and paired-pulse facilitation (PPF) in response to twin stimulations is reduced. Here, intracellular recordings from pyramidal neurons show that CCh increases PPF in the piriform cortex from odor-trained rats more than in control rats, suggesting enhanced effect of ACh in inhibiting presynaptic glutamate release after odor training. 相似文献
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Michael F. Harris Karen Shalev Greene 《Journal of Investigative Psychology & Offender Profiling》2016,13(3):253-266
The aim of this article is to examine the attitudes of English police officers to return interviews of people who are reported missing repeatedly (e.g. three times or more). In addition to a brief police ‘Safe & Well Check’ a return interview is also carried out by a police officer and seeks to find out where people went and why, in order to identify potential risks to their safety and whether they experienced harm whilst they were missing. A mixed‐methods survey of 50 constables from one police force in England ran in March 2014, using quantitative and open qualitative questions. Key themes that emerged were individual frustration at repetition, negativity around usefulness of the interviews, a challenge to involve third sector partners, and development areas in training. Statistical significance was found in variables relating to officer experience and gender, against views on interviewing missing people. The article looks at the limited existing literature and makes recommendations about best practice with return interviews, advocating a multi‐agency approach to improve interventions, and better training to improve positivity towards missing people. Copyright © 2016 John Wiley & Sons, Ltd. 相似文献
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Hagar Lahav 《Journal of Contemporary Religion》2016,31(1):17-34
Secular-believers, who constitute about 25% of Israeli Jews, are self-identified secular people who believe in some kind of divinity. Based on in-depth interviews with secular-believer women, this study aims to reveal their theological assumptions and claims. It examines metaphors and images participants used to relate to the divine as well as the theological categories they emphasized. The study uncovers the pluralistic nature of secular-believers’ beliefs and the common tendency to address faith-related content in a positive light. 相似文献
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Rebecca A. Shalev Suzanne M. Milnes Cathleen C. Piazza Jennifer M. Kozisek 《Journal of applied behavior analysis》2018,51(1):70-79
In the current investigation, we compared and evaluated the effects of two intervention procedures, a modified chin prompt and reclined seating, on the liquid expulsion of 2 children with feeding disorders. For both participants, expulsion decreased to clinically meaningful levels when we added the modified chin prompt or reclined seating to a treatment package consisting of differential reinforcement of acceptance, nonremoval of the cup, and re‐presentation. We discuss possible mechanisms underlying the effects of the 2 interventions and areas for future research. 相似文献
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In four experiments participants were instructed to detect and localise a gap on a small vertical line. When the line was presented at the periphery, inattention produced a tendency to report broken lines as solid ones and also produced a substantial increase in coarse localisation errors. The results support the hypothesis (Tsal & Shalev, 1996) that the unattended visual field is composed of large attentional receptive fields (ARFs) within which there is no spatial resolution. A partial stimulation of such an ARF, by the broken line's inner ends producing the gap, signals the activation of the entire ARF resulting in the perceptual closure of the gap. 相似文献