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31.
原发性胆汁性肝硬化(PBC)是一种以慢性进行性胆汁淤积为特点的自身免疫性肝病,血清中抗线粒体抗体(AMAs),尤其AMA-M2升高是该病的特异性表现.AMAs在PBC发病过程中的作用是研究重点之一.丙酮酸脱氢酶复合物(PDC)的E2亚单位(PDC-E2)是AMAs的主要抗原.诱发AMAs靶抗原暴露和打破免疫耐受的主要诱因是感染及化学因素.后者或与靶抗原交叉反应,或通过对靶抗原的化学修饰,或是使凋亡后抗原的清除发生障碍,从而促进AMAs的产生.针对PDC-E2的细胞免疫主要参与PBC的发病.AMAs在PBC发病中的作用存在争议,更多研究认为其不参与PBC的发病. 相似文献
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本研究旨在观察妊娠晚期亚临床甲状腺功能减退症对母婴合并症的影响。最终选择2010年1月~2010年11月期间共325例妊娠晚期孕妇分为病例组(A组,n=65)和正常对照组(B组,n=260),观察两组之间母婴合并症的变化。结果显示,两组之间在年龄、住院日、血压、体质量指数(BM I)、心率、分娩时孕周、血糖以及血脂方面差异均无统计学意义(P>0.05)。但与B组相比较,A组发生母亲合并症及胎儿合并症的发生率明显增加,差异有统计学意义(P<0.05)。此研究提示妊娠晚期亚临床甲状腺功能减退症增加母婴合并症的风险。 相似文献
33.
随着人们对于肿瘤性疾病的发生、发展、转移机制的进一步探索,循环肿瘤细胞(CTCs)逐渐进入人们视野,其应用价值日益体现,可用于肿瘤性疾病的早期诊断及治疗效果的监测,尤其是对于早期肿瘤的诊断具有独特优势。其富集技术及检测方法也在发生着日新月异的变化。近年来,微流控分析芯片技术运用于 CTCs 的富集及检测,具有高丰度、高富集度、高活性及不需要对样本进行预处理等优点使得人们聚焦于此技术,本文对微流控分析芯片在 CTCs 检测中的运用做简要综述。 相似文献
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The effect of cognitive reappraisal on long‐term emotional experience and emotional memory
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Hyeon Min Ahn Shin Ah Kim In Jae Hwang Ji Woon Jeong Hyun Taek Kim Stephan Hamann Sang Hee Kim 《Journal of Neuropsychology》2015,9(1):64-76
One's ability to properly regulate emotion is critical to psychological and physical well‐being. Among various strategies to regulate emotion, cognitive reappraisal has been shown to modulate both emotional experience and emotional memory. However, most studies of reappraisal have focused on reappraisal of negative situations, with reappraisal of positive emotion receiving considerably less attention. In addition, the effects of reappraisal on emotional reactions to stimuli are typically only assessed either immediately or after a short delay, and it remains unclear whether reappraisal effects persist over longer time periods. We investigated the effect of cognitive reappraisal on emotional reactions and long‐term episodic memory for positive and negative stimuli. Men and women viewed emotionally negative, positive, and neutral pictures while they were instructed to either increase, decrease, or maintain the initial emotional reactions elicited by the pictures. Subjective ratings of emotional valence and arousal were assessed during the regulation task and again after 1 week. Memory for the pictures was assessed with free recall. Results indicated that pictures accompanied by instructions to increase emotion were better recalled than pictures reappraised to decrease emotion. Modulation of emotional arousal elicited by stimuli persisted over a week, but this effect was observed only for men. These findings suggest that cognitive reappraisal can have long‐lasting effects on emotional reactions to stimuli. However, the sex differences observed for the effects of reappraisal on emotional reactions highlight the importance of considering individual differences in the effects of regulation. 相似文献
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Exploratory factor analysis (EFA) and confirmatory factor analysis (CFA) were used to investigate the factor structure of coping in mothers with high levels of life stress. In Study 1, EFA of the Coping Orientation to Problems Experienced (C. S. Carver, M. F. Scheier, & J. K. Weintraub, 1989) in a sample of mothers of full-term or very low birth weight 2-year-old children yielded 7 reliable coping factors. Each factor accounted for significant variance in at least 1 of 6 outcomes measuring maternal-child well-being. In Study 2, CFA was used to cross-validate the EFA model on the basis of the responses of mothers of 2-year-old children with prenatal polysubstance exposure. CFA results revealed a moderately good fit, confirming the factor structure in a 2nd, independent sample of mothers with high levels of life stress. 相似文献
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David Schultz Archana Ambike Sean Kevin Logie Katherine E. Bohner Laura M. Stapleton Holly VanderWalde Christopher B. Min Jennifer A. Betkowski 《Journal of abnormal child psychology》2010,38(5):601-613
Crick and Dodge’s (Psychological Bulletin 115:74–101, 1994) social information processing model has proven very useful in guiding research focused on aggressive and peer-rejected children’s
social-cognitive functioning. Its application to early childhood, however, has been much more limited. The present study responds
to this gap by developing and validating a video-based assessment tool appropriate for early childhood, the Schultz Test of
Emotion Processing—Preliminary Version (STEP-P). One hundred twenty-five Head Start preschool children participated in the
study. More socially competent children more frequently attributed sadness to the victims of provocation and labeled aggressive
behaviors as both morally unacceptable and less likely to lead to positive outcomes. More socially competent girls labeled
others’ emotions more accurately. More disruptive children more frequently produced physically aggressive solutions to social
provocations, and more disruptive boys less frequently interpreted social provocations as accidental. The STEP-P holds promise
as an assessment tool that assesses knowledge structures related to the SIP model in early childhood. 相似文献
40.
“多少”概念发展的研究 总被引:1,自引:0,他引:1
采用数量判定任务,分别用2~30和5~100范围内点子图为刺激,研究个体“多”和“少”概念的发展。结果发现:在5~100点子条件下,随年龄的增长,个体“多”概念的判断值、“少”概念的判断值、“多”“少”概念的临界值均显著增大;7~9岁是个体“多少”概念发展的转折期;个体对“多少”概念的认知具有相对性;在本实验的两种条件下,随年龄增长,个体“多”概念的判断值、“少”概念的判断值、“多”“少”概念的临界值逐渐趋于刺激点子数最大值的2/3、1/3、1/2,“多”概念与“少”概念判断的不确定距离逐渐趋于刺激点子数最大变化范围的1/3或略小于1/3。 相似文献