PSYCHOPHYSIOLOGICAL REACTIONS TO TWO DIFFERENT PLACEBO TREATMENTS

Reactions to a placebo introduced either as a depressant or as a stimulant drug were examined in 16 healthy female subjects. Comparisons between pre- and post-placebo measurements showed that the two treatments produced marked effects in opposite directions: (1) the 'depressant' placebo produced a statistically significant decrease in pulse rate, blood pressure, objective and subjective reaction speed, as well as significant effects on subjective mood in the expected directions, and (2) the 'stimulant' placebo produced opposite and significant changes in all variables. The subjective reactions were, on the whole, more pronounced than the effects on performance and physiological functions.     

Effects of pentobarbital on fixed-ratio reinforcement,

Certain doses of pentobarbital consistently increased the rate of pecking engendered by a fixed-ratio schedule of 30 responses in a group of 13 pigeons, and still higher doses produced decrements in rate of responding. For individual subjects, the dose-effect functions were qualitatively similar, but differed with respect to the doses producing the maximum increase and subsequent decrease in rate. In general, the maximum occurred at lower doses and the decrement was greater at the highest dose in the birds with the highest control rates. It was also possible to distinguish between the effects of pentobarbital and several other drugs on the behavior maintained by FR 30. The results indicate that changes in rate of responding on FR 30 after drug administration are dose-dependent, drug-specific effects.     

The recording of continuous variation along four dimensions

A system is described for signalling, recording and analysing continuous changes in up to four dimensions applicable to the visual after-image and other phenomena. Some advantages of the method are discussed.     

Generalization gradients of inhibition following auditory discrimination learning

A more direct method than the usual ones for obtaining inhibitory gradients requires that the dimension of the nonreinforced stimulus selected for testing be orthogonal to the dimensions of the reinforced stimulus. In that case, the test points along the inhibitory gradient are equally distant from the reinforced stimulus. An attempt was made to realize this condition by obtaining inhibitory gradients along the frequency dimension of a pure tone after discrimination training in which the nonreinforced stimulus was a pure tone (or tones), and the reinforced stimulus was either white noise or the absence of a tone. The results showed that some degree of specific inhibitory control was exerted by the frequency of the tone, although the gradients were broad and shallow in slope.

A further experiment was conducted to see whether the modification of an excitatory gradient resulting from training to discriminate neighboring tones could arise from a simple interaction of inhibitory and excitatory gradients. The results indicated that it could not, since discrimination training produced a concentration of responding in the vicinity of the reinforced stimulus which cannot be derived from any plausible gradient of inhibition.

     

Some statistical treatments compatible with individual organism methodology

Consider experimental treatments with consequences so irreversible that baseline performance cannot be recovered. The conventional method of assessing the effects of such treatments by statistical means involves separate experimental and control groups. An alternative proposed here is to administer the experimental treatment to each subject, one subject at a time and in a random order; whenever any subject receives the experimental treatment, those subjects which have not yet received it receive a control treatment. This procedure permits results significant at the one-tailed 0.05 level to be obtained with four subjects; if a two-group procedure evaluated by means of the U test is used, a minimum of six subjects is needed for the same significance level. More generally, the procedure permits equal sensitivity to any experimental effect with over 30% fewer subjects than a two-group procedure. Extensions of the basic method are made to a variety of levels of the experimental treatment and to treatments without irreversible effects, and limitations of the method are discussed.     

A new principle of pellet feeder design

Most current commercial devices dispense dry food pellets by moving the pellets horizontally toward a discharge point. Individual pellets, captured by perforations in a horizontal metal disk, are discharged one by one by stepwise rotation of the disk within the pellet reservoir. In our laboratory, where the average pellet discharge rate is some 20,000 pellets per week, feeders of this type produced occasional problems. Some were electronic; others involved failure always to capture a pellet in each perforation, particularly when the pellet supply was low. But the most common problem was an accumulation of pellet chips and dust under and around the perforated disk, which ultimately jammed the mechanism. Despite weekly cleaning and maintenance, troubles arose at least twice a month, prompting a search for a simpler pellet-feeder design which would be more reliable and require less maintenance. The present pellet feeder employs a vertical rather than horizontal design principle. It has been used extensively in operant conditioning applications for more than a year. More than 200,000 pellets have been reliably discharged from a single feeder without a breakdown. No maintenance, other than a weekly cleaning of the discharge tube, has been required.