Working memory theory of hippocampal function needs qualification

To compare the predictive value of "cognitive map" and "working memory" theories of hippocampal function, the performance of rats with dorsal hippocampal lesions was compared to that of control rats in a series of experiments. In Experiment I, experimental rats learned a spatial alternation task with normal ease, but in Experiment II, they were significantly impaired on an elevated 8-arm radial maze. In Experiment III, the performance of the same experimental and control rats was compared on two versions of a 16-arm enclosed radial maze. In the first version, carpet inserts served as cues to mark eight unbaited arms and each of the remaining arms contained one food pellet. While both experimental and control rats successfully avoided the set of cued arms, experimental rats reentered uncued baited arms more frequently than did control rats. In the second version no intramaze cues were provided, but the spatial distribution of baited and unbaited arms remained the same as that used in the first version. In this uncued version, experimental rats both entered unbaited arms and reentered baited arms more frequently than did control rats, i.e., they were impaired in both "reference" and "working" memory. These findings are compatible with the hypothesis that hippocampal lesions result in an impaired capacity to form cognitive maps but they are not compatible with the working memory hypothesis. Furthermore, twelve separate evaluators classed experimental rats as using fewer mapping and more orientation strategies than control rats in the 8-arm maze.     

Reading-disabled hyperactive children: A distinct subgroup of Attention Deficit Disorder with Hyperactivity?

Mixed hyperactive/reading-disabled children, selected from a large sample of hyperactive children, were compared to pure hyperactive children on demographic, behavioral, and neuropsychological measures. Children in the Mixed group were reading-disabled relative to age and IQ; those in the Pure group had achievement scores that were average relative to age and IQ. The Mixed group was significantly older than the Pure group; there were no differences in gender, race, or socioeconomic status. Behaviorally, the groups did not differ significantly on teacher ratings or on psychiatric ratings of aggression. The Mixed group had a significantly higher Performance IQ, whereas the Pure group had a significantly higher Verbal IQ and performed better on measures of cognitive impulsivity. Several other measures failed to distinguish the groups. The data give minimal support to the notion that pure hyperactive and mixed hyperative/reading-disabled children constitute distinct subgroups of Attention Deficit Disorder with Hyperactivity.This research was supported in part by Mental Health Clinical Research Grant MH-30906 and by U. S. Public Health Service Grant MH-18579.     

Performance differences following exposure to predictable and unpredictable noncontingent outcomes in high and low achievers

Two experiments are described in which subjects rated as high or low in achievement motivation were exposed to uncontrollable outcomes on a cognitive task. Effects on subsequent performance on a different cognitive task were shown to depend on level of achievement motivation, on whether the uncontrollable outcomes were predictable or unpredictable, and on whether the uncontrollable outcomes were positive or negative. These findings have important theoretical implications which are discussed.     

Bilingual frequency encoding

Two experiments are reported that examine the nature of the processing of frequency information in Spanish-English bilinguals. In the first study, subjects studied a list of English-only, Spanish-only, and mixed-language words varying in their frequency of occurrence, and under conditions of being either informed or uninformed about the later frequency test. Subjects were then shown pictures represeting the nominally presented items and had to give frequency judgments for the words depicting the objects. Frequency judgments were significantly faster when the words had been presented in a single language, suggesting a summation of access times for the mixed-language words. Instructional conditions had no effect on frequency judgments, but the latency to judge was significantly reduced for the informed subjects. In the second study, using similar acquisition procedures, subjects were shown test words in either the same or the different language from the one in which the words were originally experienced. Subjects demonstrated a clear ability to assign frequencies according to the relationship between acquisition and test language. The data were discussed in terms of supporting the hypothesis of separate bilingual language processing, and implications for the automatic nature of frequency acquisition were also addressed.This article is based on a paper originally presented at the meetings of the Southwestern Psychological Association, San Antonio, April 1983.     

Evidence for the involvement of brain GABA and serotonin systems in the anticonflict effects of chlordiazepoxide in rats

Using male hooded Lister rats the effects of GABAergic and serotonergic treatments alone and with chlordiazepoxide (CDP) were compared with the behavioral effects of CDP in a conditioned conflict procedure with three components; Reward, Time Out, and Conflict. CDP (2.5, 5.0, and 10.0 mg/kg ip) dose- relatedly increased punished and time out responding, but increased rewarded responding in an inversely dose-related manner. Punished responding was enhanced by chronic treatment to a rate which remained stable between 9 and 19 injections. The GABA transaminase inhibitor ethanolamine-O-sulfate (EOS), given chronically in drinking water (5.0 mg/ml), increased punished responding linearly to a high stable level after 2-3 weeks. Rewarded and time out responding were less substantially increased. CDP given with EOS dose- relatedly increased time out and punished responding substantially above the rates found with either treatment alone. The GABA antagonist picrotoxin blocked the increase in punished and time out responding found with EOS and CDP alone. The tryptophan hydroxylase inhibitor p-chlorophenylalanine (PCPA; 100 mg/kg x 3) linearly increased punished responding for the first week of treatment. CDP with PCPA selectively and significantly increased punished responding above the rates for either treatment alone, but the increases were not as substantial as those with EOS + CDP. The serotonin reuptake inhibitor Wy 25093 reduced increases in time out and punished responding under CDP, and the precursor 5-hydroxytryptophan (5-HTP) counteracted increases in punished responding under PCPA but also substantially reduced rewarded responding. These results provide evidence that both increased GABA and decreased serotonin transmission are involved in the anticonflict effects of CDP, as EOS and PCPA both mimicked and potentiated effects of CDP, while picrotoxin, Wy 25093, and 5-HTP counteracted them.(ABSTRACT TRUNCATED AT 250 WORDS)     

Increased novelty-induced grooming in aged rats: a preliminary observation

Age-related changes in grooming activity in female Fischer-344 rats were observed in a home cage and in a novel testing chamber for 50 min. Compared to the home cage condition with brief handling treatment, excessive grooming was found in the novel situation. The amount of novelty-induced grooming of aged rats (26-28 months) was about two times that of young animals (6-8 months). This increase in novelty-induced grooming of aged animals was attributable to an increase in the number of grooming bouts, prolongation of each grooming bout, and a slight increase in the duration of licking elements. However, there were no age differences in the percentage of face washing and the duration of face-washing elements. These results are discussed in terms of behavioral aging and age-related changes in peptidergic pathways in the brain.     

Age norms for impulsiveness,venturesomeness and empathy in children

A total of 1505 children (633 boys and 872 girls) completed the I₆ Impulsiveness Questionnaire. Reliabilities, scale intercorrelations and means and standard deviations are given after slight modifications were made to the original scoring key on the basis of factor analyses. Age means for both sexes are also given.     

A temperamental and development model for personality assessment: application to self-control in middle childhood

In personality theory and assessment, it is important to distinguish between dispositional and developmental constructs. This important but often neglected distinction is applied to general personality models, and, specifically, to psychological temperament dimensions and ego development. These conjoined domains are used as a framework to study impulsivity and self-control in a sample of middle-childhood boys. Impulsivity is conceptualized as a temperamental dimension and self-control as an ego-developmental dimension. A factor-analytic procedure was used to test the assumption of orthogonality between impulsivity and self-control. Results were consistent with the hypothesis and provide implications for the concept of ‘difficulty’ of temperament constellations and study of ego development in middle childhood.     

Interrogative suggestibility and delinquent boys: An empirical validation study

This study has several aims. First, to validate the Gudjonsson Suggestibility Scale (GSS) among delinquent and adolescent boys placed in an assessment and short-term treatment centre. Second, to test the hypothesis that adolescent boys are particularly susceptible to suggestions when they are ‘pressured’ by negative feedback and instructions. Finally, to investigate the hypothesis that suggestibility is related to memory recall and self-esteem. The GSS was administered to 31 boys (ages 11 to 16 yr) who had been independently rated by two teachers on measures of suggestibility and self-esteem. Suggestibility as measured by the GSS was found to correlate significantly with the teachers' ratings of suggestibility, supporting empirically the criterion-related validity of the GSS. Compared with young ‘normal’ adults the boys were no more likely to give in to suggestive questions than the adults, unless their performance was subjected to criticism and negative feedback. The results suggest that deliquent adolescents may be particularly responsive to interpersonal pressure during interrogation. The findings have important implications for police interrogation procedures.     

Development of differences in response latencies to right and left visual fields

Robust lateralization developed in right-handed adults who were asked to judge letter pairs as "same" or "different" during 4608 trials. By the end of the first two blocks (768 trials) "same" responses were favored when presented in the RVF (transmitted directly to the left hemisphere) and "different" responses were favored when presented in the LVF (transmitted direction to the right hemisphere). This gradually reversed over sessions with "same" responses becoming faster for letters presented in the LVF, and "different" responses becoming faster for stimuli presented in the RVF. The laterality acquired under these conditions was cumulative and reproducible, appeared in all 16 subjects, and was preserved between sessions a week apart. The data suggest that laterality is a flexible and reversible characteristic of the human brain even when stimulus and task remain constant.