Functional and pharmacological characterization of the first specific agonist and antagonist for the V1b receptor in mammals

By activating three distinct vasopressin receptor isoforms called V1a-R, V1b-R (V3-R) and V2-R, vasopressin (VP) mediates a wide number of biological effects in mammals and may be involved in several pathological states. Up to now only specific V1a and V2 receptor agonists and antagonists have been successfully designed. The role of the V1b-R still remains partially unknown, due to the lack of selective V1b-R ligands and orally-active molecules, which are crucial tools for investigating the central and peripheral functions or pathological disorders associated with this receptor. In this review, we report the biological and pharmacological properties of the first two specific V1b-R ligands: d[Cha4] AVP, a high affinity V1b-R agonist and SSR149415, a potent orally-active V1b-R antagonist with good selectivity with respect to other VP/OT receptor isoforms and able to control ACTH secretion in vitro and in vivo. Indeed, these molecules constitute invaluable tools for exploring the central and peripheral roles of VP mediated via V1b receptors. Interestingly, SSR149415 displays potent anxiolytic and antidepressant-like activities, indicating that this new class of drugs has a promising therapeutical potential in the treatment of stress-related disorders, anxiety and depression.     

Attachment-based family therapy for depressed adolescents: programmatic treatment development

Few effective psychosocial treatment models for depressed adolescents have been developed, let alone ones that use the developmentally potent context of the family as the focus of intervention. Attachment-based family therapy (ABFT) is a brief, manualized treatment model tailored to the specific needs of depressed adolescents and their families. Attachment theory serves as the main theoretical framework to guide the process of repairing relational ruptures and rebuilding trustworthy relationships. Empirically supported risk factors for depression are the primary problem states that therapists target with specific treatment strategies or tasks. Parent problem states include criticism/hostility, personal distress, parenting skills, and disengagement. Adolescent problem states include motivation, negative self-concept, poor affect regulation, and disengagement. Intervention tasks include relational reframing, building alliances with the adolescent and with the parent, addressing attachment failures, and building competency. A small, randomized clinical trial provides initial support for the model. Several process research studies, using both qualitative and quantitative methods, have helped refine the clinical guidelines for each treatment task. ABFT is a promising new treatment for depressed adolescents and more research on it is warranted.     

Assessing the Experience of Autonomy in New Cultures and Contexts

This research demonstrates the usefulness of the technique of Smallest Space Analysis (SSA) in the construction of indices of the experience of autonomy, a central construct in Ryan and Deci’s self-determination theory of motivation and personality (SDT, 2000) and a construct central to recent controversies on socialization in different cultures. We propose that SSA has two advantages in comparison to correlation tables in the assessment of the experience of autonomy. First, it allows easy identification of items that best capture the various motivations along the relative autonomy continuum postulated by SDT. Second, and more important, it can reveal data patterns that might contribute to theoretical refinement that otherwise might remain unnoticed. These advantages were demonstrated in three Israeli samples: two samples of elementary school children (n = 697 and n = 417), and one sample of high school students (n = 317). Discussion considers ways in which SSA can contribute to the development and refinement of measures and theory pertaining to the experience of autonomy in cultures and contexts not examined so far.

Attentional blink differences between adolescent dyslexic and normal readers

The goal of this study was to evaluate the possibility that dyslexic individuals require more working memory resources than normal readers to shift attention from stimulus to stimulus. To test this hypothesis, normal and dyslexic adolescents participated in a Rapid Serial Visual Presentation experiment (Raymond, Shapiro, & Arnell, 1992). Surprisingly, the result showed that the participants with dyslexia produced a shallower attentional blink than normal controls. This result may be interpreted as showing differences in the way the two groups encode information in episodic memory. They also fit in a cascade-effect perspective of developmental dyslexia.     

The origin of exemplar effects in rule-driven categorization

S. W. Allen and L. R. Brooks (1991) have shown that exemplar memory can affect categorization even when participants are provided with a classification rule. G. Regehr and L. R. Brooks (1993) argued that stimuli must be individuated for such effects to occur. In this study, the authors further analyze the conditions that yield exemplar effects in this rule application paradigm. The results of Experiments 1-3 show that interchangeable attributes, which are not part of the rule, influence categorization only when attention is explicitly drawn on them. Experiment 4 shows that exemplar effects can occur in an incidental learning condition, whether stimulus individuation is preserved or not. The authors conclude that the influence of exemplar learning in rule-driven categorization stems from the attributes specified in the rule or in the instructions, not from the stimulus gestalts.     

Supervisees' perspectives on the contribution of supervision to psychotherapy outcomes

Objective

The aim of this study was to examine supervisees' perspectives about the contribution of two predefined aspects of supervision, supervisory bond (SB) and didactic input of supervisor (DI), to their ascribed outcome of therapy.

Method

Supervisees anonymously assessed the SB, supervisors' DI and their contribution to therapy outcome. Assessment was quantitative and qualitative. The supervisory aspects were assessed using a questionnaire constructed for this study. Perceived contribution was evaluated by two scaled questions, and themes generated by an open question. Supervisees (n = 111) evaluated 16 supervisors and supervision’s contribution to psychotherapy outcomes of 111 clients.

Findings

Hierarchical regression showed that supervisees' age, supervisors' status and frequency of supervision accounted for 24% of the variance ascribed to outcome. SB and DI accounted for 51% of the variance. These values, which are higher than reported in the literature, may be attributed to the assessment of predefined aspects of supervision by the same assessor. Thematic analysis of the didactic input produced more themes than for the supervisory bond.

Conclusion

Sociodemographic variables and supervisory relationship variables determine supervisees' evaluations of supervision’s contribution to outcome.

Implications for practice

Training and supervision may benefit from information obtained from quantitative and qualitative measures regarding these and other predefined variables related to supervision. The in-depth look at views and experiences shared by supervisees may advance training, practice and research.     

Talking to a (Segregation) Wall: Intergroup Contact and Attitudes Toward Normalization Among Palestinians From the Occupied Territories

This article examines how Palestinians' intergroup contact experiences relate to their attitudes towards interactions with Israelis (i.e., normalization). We draw on four recent advances in intergroup contact literature. First, recent research indicates that positive contact can impede disadvantaged groups' motivation to challenge inequalities. Second, increased endorsement of normalization mediates this sedative effect of positive contact on motivation to resist in the West Bank. Third, negative contact has been related to increased motivation for social change. Fourth, institutions and societal norms shape the meaning of intergroup contact and its effect on intergroup relations. We hypothesize that negative experiences at checkpoints can act as reminders of institutionalized inequalities and thus attenuate sedative effects. Furthermore, we explore the contextual boundary conditions of such reminder effects. Analyses of cross-sectional survey conducted among a representative sample (N = 1,000) in the West Bank including Jerusalem showed that (1) positive intergroup contact related to normalization endorsement (sedative effect), (2) negative intergroup contact related to decreased normalization endorsement (mobilizing effect), and (3) negative contact experiences (at checkpoints) canceled out the effect of positive contact (reminder effect), but only in Jerusalem. Results suggest that the impacts of intergroup contact need to be interpreted in light of institutionalized forms of group inequality and segregation.     

Nietzsche's Critique of Pure Altruism—Developing an Argument from Human,All Too Human

Abstract

Nietzsche often appears, especially in his writings from the middle period, to endorse psychological egoism, namely the claim that all actions are motivated by, and are for the sake of, the agent’s own self-interest. I argue that Nietzsche’s position in Human, All Too Human (Cambridge: Cambridge University Press, 1986) should not be so understood. Rather, he is claiming, more weakly and more plausibly, that no action is entirely unegoistic, entirely free of egoistic motivations. Thus some actions might be motivated both by egoistic and unegoistic motives, on his view. Nietzsche’s argument may, in other words, be understood to be directed specifically against Schopenhauer’s portrayal of moral motivation, as pure, entirely unalloyed altruism, to show that this sort of action is impossible, not to rule out the possibility of any altruistic motive whatsoever. In light of Schopenahuer’s moral psychology, to which Nietzsche to some extent adhered at that time, I develop a concept of motivation and reconstruct Nietzsche’s argument.