Development switch in neural circuitry underlying odor-malaise learning

Fetal and infant rats can learn to avoid odors paired with illness before development of brain areas supporting this learning in adults, suggesting an alternate learning circuit. Here we begin to document the transition from the infant to adult neural circuit underlying odor-malaise avoidance learning using LiCl (0.3 M; 1% of body weight, ip) and a 30-min peppermint-odor exposure. Conditioning groups included: Paired odor-LiCl, Paired odor-LiCl-Nursing, LiCl, and odor-saline. Results showed that Paired LiCl-odor conditioning induced a learned odor aversion in postnatal day (PN) 7, 12, and 23 pups. Odor-LiCl Paired Nursing induced a learned odor preference in PN7 and PN12 pups but blocked learning in PN23 pups. 14C 2-deoxyglucose (2-DG) autoradiography indicated enhanced olfactory bulb activity in PN7 and PN12 pups with odor preference and avoidance learning. The odor aversion in weanling aged (PN23) pups resulted in enhanced amygdala activity in Paired odor-LiCl pups, but not if they were nursing. Thus, the neural circuit supporting malaise-induced aversions changes over development, indicating that similar infant and adult-learned behaviors may have distinct neural circuits.     

Aripiprazole-related tardive dyskinesia

The low prevalence of extrapyramidal symptoms associated with atypical antipsychotics has led to their widespread use during the past decade. Aripiprazole, the newest medication in this class, has been associated with extrapyramidal symptoms (eg, akathisia) and with improvement of tardive dyskinesia (TD), but to date it has not been associated with the development of TD. We report a case of TD associated with the use of aripiprazole 15 mg/day for 18 months for refractory depression. Symptoms of TD resolved within several weeks of discontinuation of aripiprazole.     

Responses to symptom induction exercises in panic disorder

Exposure to panic symptoms (interoceptive exposure) is often included as part of treatment for panic disorder (PD), although little is known about the relative effects of particular symptom induction exercises. This study describes responses of individuals with PD and nonclinical controls to 13 standard symptom induction exercises and 3 control exercises. Generally, individuals with PD responded more strongly to symptom induction exercises than did controls. The exercises producing the most fear included spinning, hyperventilation, breathing through a straw, and using a tongue depressor. This study also reports findings regarding specific symptoms triggered by each exercise, the percentage of participants reporting fear during each exercise, and predictors of fear.     

The classification of violence risk

The Classification of Violence Risk (COVR) is an interactive software program designed to estimate the risk that a person hospitalized for mental disorder will be violent to others. The software leads the evaluator through a chart review and a brief interview with the patient. At the end of this interview, the software generates a report that contains a statistically valid estimate of the patient's violence risk-ranging from a 1% to a 76% likelihood of violence-including the confidence interval for that estimate, and a list of the risk factors that the program took into account to produce the estimate. In this article, the development of the COVR software is described and several issues that arise in its administration are discussed.     

Investigating the M-FAST: psychometric properties and utility to detect diagnostic specific malingering

This study examined the ability of the M-FAST to differentiate a group of undergraduate students simulating one of four DSM-IV diagnoses (n = 190; schizophrenia, major depressive disorder, bipolar disorder, and posttraumatic stress disorder) and a clinical comparison sample drawn from previous M-FAST studies comprising individuals with the same diagnosis (n = 142). Across all diagnostic conditions, the simulators obtained higher M-FAST total scores than the clinical comparisons, and the rare combinations scale was equal or superior to the total score at differentiating the groups. The M-FAST was most efficient at distinguishing feigned from bona fide schizophrenia. Although the internal consistency of the total score was high (alpha = 0.88), inter-item correlations were lower than values reported in previous research. Lastly, given the importance of base rate considerations in the evaluation of diagnostic instruments, it was notable that the M-FAST was able to identify malingerers even at relatively low base rates.     

Easy to remember?: genocide and the philosophy of religion

Philosophers of religion have written a great deal about “the problem of evil.” Their reflections, however, have not concentrated, at least not extensively or sufficiently, on the particularities of evil that manifest themselves in genocide. Concentrating on some of those particularities, this essay reflects on genocide, which has sometimes been called the crime of crimes, to raise questions such as: how should genocide affect the philosophy of religion and what might philosophers of religion contribute to help check that crime against humanity?     

Wayfinding through an unfamiliar environment

Strategies for finding one's way through an unfamiliar environment may be helped by 2D maps, 3D virtual environments, or other navigation aids. The relative effectiveness of aids was investigated. Experiments were conducted in a large, park-like environment. 24 participants (12 men, 12 women; age range = 22-50 years; M=32, SD = 7.4) were divided into three groups of four individuals, who explored a 2D map of a given route prior to navigation, received a silent guided tour by means of an interactive virtual representation, or acquired direct experience of the real route through a silent guided tour. Participants then had to find the same route again on their own. 12 observers were given a "simple" route with only one critical turn, and the other 12 a "complex" route with six critical turns. Compared to three people familiar with the routes, among the naive participants, those who had a direct experience prior to navigation all found their way again on the simple and complex routes. Those who had explored the interactive virtual environment were unable to find their way on the complex route. The relative scale representation in the virtual environment may have given incorrect impressions of relative distances between objects along the itinerary, rendering important landmark information useless.     

On misunderstanding science

Abstract

The paper examines the differences between Kuhn's account, in The Structure of Scientific Revolutions, of the sciences as necessarily communal activities with internally set standards of procedure and achievement, and that view of the sciences which calls itself ‘Scientific Realism’ and regards them as striving toward, and perhaps asymptotically approaching, some external and objective reality that bestows truth or falsity on scientific theories.

The main argument turns on Poincaré's demonstration that Newton's Second Law (f = ma) is not a testable, provable proposition with a truth value, but something that is simply adopted. It is adopted in the light of experience, certainly, but there is no logical necessity in the adoption. My suggestion is that it is a ‘way of looking’ and ‘a method of analysis’ and that the necessity of its adoption by any individual lies in its being a necessary condition of entry into the scientific community. That community itself adopts ways of looking or methods of analysis for their fruitfulness in dealing with old problems and defining new ones.

Incoherences in the ‘approach’ account of scientific progress are looked at, and the individualistic assumptions that motivate it. These require the sciences to be presented as the source and basis of agreement and community amongst separated individuals. This picture and its requirement inverts reality as well as Kuhn's account, which makes community and agreement the starting point. The notion of reality as a transcendental convergence point becomes redundant.

The old problem of the incommensurability of paradigms is discussed by relating them to the notions of ways of looking and methods of analysis. These may be incompatible in that one cannot look at things in two different ways at once, but at the same time they cannot be measured on any common scale.     

Clinicians’ Attitudes Toward Therapeutic Alliance in E-Therapy

Although therapeutic alliance is a crucial factor in face-to-face therapies, no data exist on clinicians’ attitudes towards alliance in E-therapy. The study explored clinicians’ perceived importance of alliance in E-therapy, clinicians’ confidence in their skills to develop alliance in E-therapy, and whether attitudes towards alliance in E-therapy are associated with intended E-therapy practice. Clinicians (n = 106) responded to an online survey. The majority of clinicians considered alliance to be extremely important in both face-to-face therapy and E-therapy. However, clinicians’ ratings of the importance of alliance in face-to-face therapies were significantly higher than their ratings of the importance of alliance in E-therapy. Clinicians reported less confidence in their skills to develop alliance in E-therapy than in face-to-face therapy. Intended E-therapy practice correlated with confidence in one's ability to develop alliance in E-therapy and with previous E-therapy practice.