Recognition memory deficits in mild cognitive impairment

ABSTRACT There is no agreement on the pattern of recognition memory deficits characteristic of patients diagnosed with mild cognitive impairment (MCI). Whereas lower performance in recollection is the hallmark of MCI, there is a strong controversy about possible deficits in familiarity estimates when using recognition memory tasks. The aim of this research is to shed light on the pattern of responding in recollection and familiarity in MCI. Five groups of participants were tested. The main participant samples were those formed by two MCI groups differing in age and an Alzheimer's disease group (AD), which were compared with two control groups. Whereas one of the control groups served to assess the performance of the MCI and AD people, the other one, composed of young healthy participants, served the purpose of evaluating the adequacy of the experimental tasks used in the evaluation of the different components of recognition memory. We used an associative recognition task as a direct index of recollection and a choice task on a pair of stimuli, one of which was perceptually similar to those studied in the associative recognition phase, as an index of familiarity. Our results indicate that recollection decreases with age and neurological status, and familiarity remains stable in the elderly control sample but it is deficient in MCI. This research shows that a unique encoding situation generated deficits in recollective and familiarity mechanisms in mild cognitive impaired individuals, providing evidence for the existence of deficits in both retrieval processes in recognition memory in a MCI stage.     

Brain oscillatory activity associated with task switching and feedback processing

In this study, we sought to dissociate event-related potentials (ERPs) and the oscillatory activity associated with signals indicating feedback about performance (outcome-based behavioral adjustment) and the signals indicating the need to change or maintain a task set (rule-based behavioral adjustment). With this purpose in mind, we noninvasively recorded electroencephalographic signals, using a modified version of the Wisconsin card sorting task, in which feedback processing and task switching could be studied separately. A similar late positive component was observed for the switch and correct feedback signals on the first trials of a series, but feedback-related negativity was observed only for incorrect feedback. Moreover, whereas theta power showed a significant increase after a switch cue and after the first positive feedback of a new series, a selective frontal beta–gamma increase was observed exclusively in the first positive feedback (i.e., after the selection of the new rule). Importantly, for the switch cue, beta–alpha activity was suppressed rather than increased. This clear dissociation between the cue and feedback stimuli in task switching emphasizes the need to accurately study brain oscillatory activity to disentangle the role of different cognitive control processes.     

Pure versus guided mirror exposure to reduce body dissatisfaction: a preliminary study with university women

While effectiveness of mirror exposure to reduce body dissatisfaction has been demonstrated, the exposure was almost always combined with other interventions. The aim of the study was to evaluate the effectiveness of a pure mirror exposure intervention compared with a guided mirror exposure (participants are guided to describe their body shape in a non-evaluative manner) and an imagery exposure intervention (participants are guided to describe their body through mental representation). Thirty-one women with high body dissatisfaction received five sessions of treatment under one of the three conditions. All interventions reduced body dissatisfaction, but only the mirror exposures successfully reduced the frequency of negative thoughts and feelings of ugliness. Pure mirror exposure was more effective than guided exposure for reducing body discomfort within and between sessions. Pure mirror exposure, based on the traditional extinction paradigm, led to strong emotional activation followed by a fast decrease in emotional reactivity.     

Emotional nouns affect attachment decisions in sentence completion tasks

We report three sentence completion experiments in which we manipulate the emotional dimension of the nouns in a complex noun phrase (NP) that precedes a relative clause (RC), as in the classic ambiguity in Someone shot the servant of the actress who was on the balcony. The aim was to see whether nouns such as orgy or genocide affect the well-established preference of Spanish to adjoin the relative clause high in the tree (to servant instead of actress in the example above). We manipulated the valence and arousal of the lexical entities residing in the NP. Our results indicate that (a) the inclusion of either pleasant or unpleasant words induces changes in the usual NP1 preference found in Spanish; (b) the effects of high-arousal words are especially clear, in that they pull RC adjunction towards the NP where they are located, be it the NP1 or the NP2; and (c) in the context of sentence production, these kinds of words seem intense enough to promote changes in (and even reverse) a solid syntactic bias. We discuss these findings in the light of existing theories of syntactic ambiguity resolution.     

Reliability and Validity of a Brief Clinician-Report Scale for Screening Behavioral Inhibition

Given the implications of behavioral inhibition (BI) on social anxiety and depression, several cost-effective methods have been developed to detect this trait. However, there is no instrument for obtaining a systematic measurement of BI that uses the reports of mental health professionals. The present study aims to explore the psychometric properties of the Behavioral Inhibition Observation System (BIOS), a brief tool enabling clinicians to provide a quick measure of BI. Parents and teachers of 361 preschool children provided measures of BI and psychopathology. Clinicians completed the BIOS after an individual meeting with every child. Seventy-four randomly selected children were exposed to standardized observation. Two researchers completed the BIOS after standardized observation. The results show that the BIOS is structured in one dimension that explains 60 % of the total variance. It shows good internal consistency (Cronbach’s Alpha?=?.88) and good test-retest reliability. The BIOS scores moderately converge with observational measures of BI and adequately distinguish constructs not related to BI (such as aggressiveness, disruptive behavior, or peer conflict). The results support that the BIOS, an 8-item scale that takes 3 min to complete, is valid and reliable for capturing a clinician’s measure of BI. The BIOS may help to detect temperamental disposition to social anxiety.     

A contextual approach on sex-related biases in pain judgements: The moderator effects of evidence of pathology and patients’ distress cues on nurses’ judgements of chronic low-back pain

Although women report feeling more pain than men, their pain is often underdiagnosed and undertreated. By proposing a gender-based theoretical conceptualisation, we argue that such sex-related biases may be enhanced or suppressed by contextual variables pertaining to the clinical situation, the perceiver or the patient. Consequently, we aimed to explore the moderator role of two clinically relevant variables in a chronic low-back pain (CLBP) scenario: diagnostic evidence of pathology (EP) and pain behaviours conveying distress. One-hundred and twenty-six female nurses (M?=?35.33, SD?=?7.64) participated in an experimental between-subjects design, 2 (patient's sex)?×?2 (EP: present vs. absent)?×?2 (pain behaviours: with vs. without distress). Independent variables were operationalised by vignettes depicting a patient with CLBP. Nurses judged the patient's pain on several dimensions: (1) credibility; (2) disability; (3) severity of the clinical situation; (4) psychological attributions and (5) willingness to offer support. Main findings showed that judgements of women's pain were influenced by EP, while judgements of men's pain were not. Moreover, nurses showed biases against men, but only in the presence of EP. The influence of distress cues was less consistent. Theoretical and practical implications are drawn.     

Emotional (Non-)Expression and Health: Data,Questions, and Challenges

The available evidence on the relationship between expression and non-expression of emotions (E/NE) and health is selectively and critically reviewed. It is concluded that research in this field still lacks conceptual lucidity with regard to the many existing E/NE concepts. Despite the fact that few studies adopted appropriate designs for examining causal relationships, some intriguing results have been reported showing promise for the future. These results involve prospective associations between E/NE and chronic disease, such as cardiovascular disease and HIV infection related outcomes. Future studies have to better discriminate between (i) various forms of E/NE, (ii) different (social) contexts of E/NE as well as different cognitive decision processes underlying E/NE, and (iii) individuals for whom different forms of E/NE may be adaptive. We recommend that besides (quasi)experimental studies on the potential mechanisms involved, more prospective studies are conducted in this field in order to allow for causal inferences.     

Neurological subtle signs and cognitive development: A study in late childhood and adolescence

Introduction and Aim: Neurological subtle signs (NSS) are often observed during the neurological examination of children and tend to disappear with age. Their persistence into late adolescence or young adulthood has been related to psychiatric and neurocognitive disorders. To provide a better understanding of their functional basis, a longitudinal correlational study with neurocognitive measurements was performed.

Method: We conducted multiple regression and correlation analyses of NSS with demographic and cognitive measures on a subset of 341 healthy children (56% males), taking part in a longitudinal dental study. Participants, whose ages ranged between 11–15 years, at first evaluation, undertook yearly, during 5 years, a 6-item NSS exam (producing a total score ranging between 0–18) and a comprehensive battery of neurocognitive tests. Effects of age, gender, IQ, and 7 neurocognitive factors on NSS were analyzed.

Results: Over the years, NSS scores correlated consistently with selective attention (Stroop test), motor speed (finger tapping), and visuomotor speed (pegboard speed).

Discussion: These results suggest that the disappearance of NSS in late childhood and adolescence occurs primarily in parallel with the development of motor and visuomotor functions and secondarily in relation to higher order functions such as selective attention (Stroop) and executive control (B-A Trails difference).     

On Ratio Measures of Confirmation

There are different Bayesian measures to calculate the degree of confirmation of a hypothesis H in respect of a particular piece of evidence E. Zalabardo (Analysis 69:630–635, 2009) is a recent attempt to defend the likelihood-ratio measure (LR) against the probability-ratio measure (PR). The main disagreement between LR and PR concerns their sensitivity to prior probabilities. Zalabardo invokes intuitive plausibility as the appropriate criterion for choosing between them. Furthermore, he claims that it favours the ordering of pairs evidence/hypothesis generated by LR. We will argue, however, that the intuitive non-numerical example provided by Zalabardo does not show that prior probabilities do not affect the degree of confirmation. On account of this, we conclude that there is no compelling reason to endorse LR qua measure of degree of confirmation. On the other side, we should not forget some technicalities which still benefit PR.