Inhibition of mTOR by rapamycin in the amygdala or hippocampus impairs formation and reconsolidation of inhibitory avoidance memory

Mammalian target of rapamycin (mTOR), a central regulator of protein synthesis in neurons, has been implicated in synaptic plasticity and memory. Here we show that mTOR inhibition by rapamycin in the basolateral amygdala (BLA) or dorsal hippocampus (DH) impairs both formation and reconsolidation of memory for inhibitory avoidance (IA) in rats. Male Wistar rats received bilateral infusions of vehicle or rapamycin into the BLA or DH before or after IA training or retrieval. Memory retention was tested at different time points after drug infusion. Rapamycin impaired long-term IA retention when given before or immediately after training or retrieval into the BLA. When infused into the DH, rapamycin produced memory impairment when given before training or immediately after retrieval. The impairing effects of post-retrieval rapamycin required memory retrieval and were not reversed by a reminder shock. The results provide the first evidence that mTOR in the BLA and DH might play a role in IA memory reconsolidation.     

Is the Continuity of Externalizing Psychopathology the Same in Adolescents and Middle–Aged Adults? A Test of the Externalizing Spectrum’s Developmental Coherence

Externalizing psychopathology (EXT) is a framework for understanding diagnostic comorbidity and etiology of antisocial and substance-use behaviors. EXT indicates continuity in adulthood but the structure of adolescent EXT is less clear. This report examines whether adolescent EXT is trait-like, as has been found with adults, or categorical. We use tests of measurement invariance to determine how diagnostic indicators of EXT differ in adolescents compared to adults. The EXT measures employed were DSM-IIIR diagnoses of adult antisocial behavior, conduct disorder, and alcohol, marijuana, and drug dependence. Latent trait, latent class, and hybrid models were fit to two separate data sets: 2,769 seventeen-year-old adolescents and 2,619 adults from the Minnesota Twin Family Study. The best model in both samples was a single-trait LT model. Parameters from the adolescent and adult models were equivalent for all disorders except alcohol dependence. It appears that EXT in adolescence can be accurately represented by a single-trait model, and the measurement properties of EXT are similar during these time periods with the exception of alcohol dependence.     

Stability and Invariance of Psychopathic Traits from Late Adolescence to Young Adulthood

The current study examined the longitudinal stability and invariance of psychopathic traits in a large community sample of male twins from ages 17 to 23. Participants were assessed across 6 years to gauge the stability and measurement invariance of the Minnesota Temperament Inventory (MTI), a Cleckley-based measure of psychopathic personality traits, and how family functioning and externalizing behavior were linked to these traits. A latent variable approach was used to model the structure of the MTI and provide a statistical test of measurement invariance across time. The results revealed support for invariance and moderate to strong stability of the MTI factors, which showed significant associations with the external correlates in late adolescence but not early adulthood.     

Truth approximation,belief merging,and peer disagreement

In this paper, we investigate the problem of truth approximation via belief merging, i.e., we ask whether, and under what conditions, a group of inquirers merging together their beliefs makes progress toward the truth about the underlying domain. We answer this question by proving some formal results on how belief merging operators perform with respect to the task of truth approximation, construed as increasing verisimilitude or truthlikeness. Our results shed new light on the issue of how rational (dis)agreement affects the inquirers’ quest for truth. In particular, they vindicate the intuition that scientific inquiry, and rational discussion in general, benefits from some heterogeneity in opinion and interaction among different viewpoints. The links between our approach and related analyses of truth tracking, judgment aggregation, and opinion dynamics, are also highlighted.     

Religious Experience Reconsidered as an example of theoretical assertiveness in the study of religion

The publication of Religious Experience Reconsidered is one more indication that the incoherent mixture of coyness and braggadocio that for decades has characterized the study of religion and other disciplines, is finally giving way to honest theoretical assertiveness. Taves' book is a careful treatment of experience deemed religious that manages to do justice to the recurrent features of what people tend to experience in such contexts, while also taking into consideration the culture-bound components of those experiences. What is especially welcome is that instead of seeking to establish a bland middle ground, she has pursued an independent path, making use of scholarship in a variety of disciplines, especially psychology of religion.     

Religion,Reductionism, and the Seduction of Epistemology

This paper examines phenomenology and its psychological relationship to religious education. It comments on this relationship in the light of the critique of phenomenology which Piaget himself made towards the end of his life (Piaget, 1965), though it also draws attention to other aspects of phenomenology theory which are dissonant with Piagetian psychology. This paper, therefore, is not a broad philosophical critique of phenomenology, though an element of this is included. but concentrates on the philosophical and developmental factors which impede the capacity of young people to perform either of the ‘reductions’ demanded by the phenomenological method.     

Verisimilitude and belief change for nomic conjunctive theories

In this paper, we address the problem of truth approximation through theory change, asking whether revising our theories by newly acquired data leads us closer to the truth about a given domain. More particularly, we focus on “nomic conjunctive theories”, i.e., theories expressed as conjunctions of logically independent statements concerning the physical or, more generally, nomic possibilities and impossibilities of the domain under inquiry. We define both a comparative and a quantitative notion of the verisimilitude of such theories, and identify suitable conditions concerning the (partial) correctness of acquired data, under which revising our theories by data leads us closer to “the nomic truth”, construed as the target of scientific inquiry. We conclude by indicating some further developments, generalizations, and open issues arising from our results.