Decision making cognition in primary progressive aphasia

We sought to investigate the decision making profile of Primary Progressive Aphasia (PPA) by assessing patients diagnosed with this disease (n = 10), patients diagnosed with behavioral variant frontotemporal dementia (bvFTD, n = 35), and matched controls (n = 14) using the Iowa Gambling Task, a widely used test that mimics real-life decision making. Participants were also evaluated with a complete neuropsychological battery. Patients with PPA were unable to adopt an advantageous strategy on the IGT, which resulted in a flat performance, different to that exhibited by both controls (who showed advantageous decision making) and bvFTD patients (who showed risk-appetitive behavior). The decision making profile of PPA patients was not associated with performance on language tasks and did not differ between sub-variants of the disease (namely, semantic dementia and progressive nonfluent aphasia). Investigating decision making in PPA is crucial both from a theoretical perspective, as it can shed light about the way in which language interacts with other cognitive functions, as well as a clinical standpoint, as it could lead to a more objective detection of impairments of decision making deficits in this condition.     

Early detection of drug use and bullying in secondary school children by using a three-dimensional simulation program

The current study analyzes the psychometric properties of an innovative three-dimensional (3D) simulation program, entitled Mii-School (MS), designed for the early detection of drug use and bullying in Secondary School children. This computer program showed adequate reliability and construct validity. The factorial structure, as well as the explanatory weight of the different factors, is presented. In addition, the results of a parallel version in paper and pencil format are also presented and compared with those of the computerized version (i.e., MS). There was a statistically significant difference between the two formats in the total (i.e., combined) sore of risk. When drug use and bullying were separately analyzed, differences were found only with regard to drug use. The relevance of these results as well as the suitability of this type of 3D instrument for the early detection of risky behaviors in young people are discussed.     

Psychometric Properties of the Child Posttraumatic Cognitions Inventory in a Sample of Brazilian Children

Cognitive models of trauma propose that maladaptive cognitions in children and adolescents are causally implicated in the unfolding and maintenance of posttraumatic response. The objective of this study was to evaluate the psychometric properties of the Child Posttraumatic Cognitions Inventory (CPTCI). The sample included 131 children and adolescents. The psychometric properties of the CPTCI were examined, including reliability and convergent validity. The results showed high internal consistency for both CPTCI total scale (α = .90) and its subscales (CPTCI–PC α = .88 and CPTCI–SW α = .79) and a 2-component solution explaining 37.63% of the variance of CPTCI. Convergent validity evidence was obtained through correlations with the Trauma Symptom Checklist for Children and Children’s Depression Inventory. Findings suggest that CPTCI instruments are reliable and had adequate evidence of validity.     

Representations in working memory yield interference effects found with externally-triggered representations

An act as simple as flicking a switch involves various stages of processing. Each stage is susceptible to interference from competing representations/processes. Interference at different stages of processing (e.g., perceptual stages versus response selection stages) leads to distinct behavioral, neural, and subjective effects. In the flanker task, for instance, one responds to a visual target and disregards flanking ‘distractors.’ Theoretically-predicted interference (increased response times, error rates, and subjective ‘urges to err’) is stronger when distractors and targets are associated with different actions (response interference) than when they look different but are associated with the same action (perceptual interference). Extant versions of the task tax working memory (WM) minimally, but many everyday actions (e.g., searching for keys or holding one's breath) require more WM-based control. To illuminate this uncharted area, we examined the nature of interference in delayed action tasks, which rely on WM. We found that systematic interference arises even when action-related representations are, not triggered solely by external stimuli, but actively held in WM. We discuss these findings with increased emphasis on the under-explored subjective effects of different kinds of interference. The implications of these findings for the study of action production, WM, and conscious processing are entertained.     

Mouse vocal communication system: Are ultrasounds learned or innate?

Mouse ultrasonic vocalizations (USVs) are often used as behavioral readouts of internal states, to measure effects of social and pharmacological manipulations, and for behavioral phenotyping of mouse models for neuropsychiatric and neurodegenerative disorders. However, little is known about the neurobiological mechanisms of rodent USV production. Here we discuss the available data to assess whether male mouse song behavior and the supporting brain circuits resemble those of known vocal non-learning or vocal learning species. Recent neurobiology studies have demonstrated that the mouse USV brain system includes motor cortex and striatal regions, and that the vocal motor cortex sends a direct sparse projection to the brainstem vocal motor nucleus ambiguous, a projection previously thought be unique to humans among mammals. Recent behavioral studies have reported opposing conclusions on mouse vocal plasticity, including vocal ontogeny changes in USVs over early development that might not be explained by innate maturation processes, evidence for and against a role for auditory feedback in developing and maintaining normal mouse USVs, and evidence for and against limited vocal imitation of song pitch. To reconcile these findings, we suggest that the trait of vocal learning may not be dichotomous but encompass a broad spectrum of behavioral and neural traits we call the continuum hypothesis, and that mice possess some of the traits associated with a capacity for limited vocal learning.     

Conflict,consensus, and liberty in J. S. Mill’s representative democracy

The relationship between representative democracy and conflict in John Stuart Mill’s political philosophy has been interpreted in very different ways. While some scholars claim that Millian democracy is incompatible with political conflict, others identify in Mill a radical political agonism that would offer a non-consensual model of deliberative democracy. This paper argues that neither of these views is exactly accurate: although he highlights the centrality of conflict in political life, Mill believes that democratic deliberation presupposes a minimal level of consensus regarding the formal value of democracy’s basic principles, viz. the principles of individual freedom and equality. Initially, I shall reconstruct the relationship between conflict and consensus in Mill’s conception of representative democracy. I shall then investigate his association of representation and advocacy and show that Mill’s encomium on political conflict was influenced by Guizot’s work. Finally, I shall explain how a democratic debate riven with conflict is conducive to individual freedom.     

Effects of long-term blindness on preparatory emg modulation in humans performing landing movements

To investigate the long-term effect of blindness on the task of leaping down to a lower landing surface, five blind individuals were compared with 10 sighted individuals who performed landing movements with and without sight. Participants performed six consecutive drop-landings from four different heights, during which the prelanding modulation of EMG timing and amplitude in four lower-limb muscles were recorded. Analysis showed that blind individuals showed specific prelanding EMG modulation, suggesting that long-term dependence on somesthetic and vestibular cues leads to different preparatory measures for vertical falls.     

Mind control? Creating illusory intentions through a phony brain–computer interface

Can one be fooled into believing that one intended an action that one in fact did not intend? Past experimental paradigms have demonstrated that participants, when provided with false perceptual feedback about their actions, can be fooled into misperceiving the nature of their intended motor act. However, because veridical proprioceptive/perceptual feedback limits the extent to which participants can be fooled, few studies have been able to answer our question and induce the illusion to intend. In a novel paradigm addressing this question, participants were instructed to move a line on the computer screen by use of a phony brain–computer interface. Line movements were actually controlled by computer program. Demonstrating the illusion to intend, participants reported more intentions to move the line when it moved frequently than when it moved infrequently. Consistent with ideomotor theory, the finding illuminates the intimate liaisons among ideomotor processing, the sense of agency, and action production.     

'Silent' priming of translation-dependent LTP by ß-adrenergic receptors involves phosphorylation and recruitment of AMPA receptors

The capacity for long-term changes in synaptic efficacy can be altered by prior synaptic activity, a process known as "metaplasticity." Activation of receptors for modulatory neurotransmitters can trigger downstream signaling cascades that persist beyond initial receptor activation and may thus have metaplastic effects. Because activation of β-adrenergic receptors (β-ARs) strongly enhances the induction of long-term potentiation (LTP) in the hippocampal CA1 region, we examined whether activation of these receptors also had metaplastic effects on LTP induction. Our results show that activation of β-ARs induces a protein synthesis-dependent form of metaplasticity that primes the future induction of late-phase LTP by a subthreshold stimulus. β-AR activation also induced a long-lasting increase in phosphorylation of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR) GluA1 subunits at a protein kinase A (PKA) site (S845) and transiently activated extracellular signal-regulated kinase (ERK). Consistent with this, inhibitors of PKA and ERK blocked the metaplastic effects of β-AR activation. β-AR activation also induced a prolonged, translation-dependent increase in cell surface levels of GluA1 subunit-containing AMPA receptors. Our results indicate that β-ARs can modulate hippocampal synaptic plasticity by priming synapses for the future induction of late-phase LTP through up-regulation of translational processes, one consequence of which is the trafficking of AMPARs to the cell surface.