Purple sweet potato color repairs d-galactose-induced spatial learning and memory impairment by regulating the expression of synaptic proteins

Purple sweet potato color (PSPC), a class of naturally occurring anthocyanins used to color food (E163), has been reported to possess a variety of biological activities, including anti-oxidant, anti-tumor, and anti-inflammatory. The effect of PSPC on the spatial learning and memory of mice treated with d-galactose (d-gal) was evaluated by the Morris water maze; d-gal-treated mice had decreased performance compared with mice in the vehicle and PSPC groups, while the PSPC + d-gal group showed significantly shortened escape latency to platform, increased swimming speed, more target quadrant search time and more platform crossings as compared with the d-gal group. Brain functions, such as memory formation and recovery of function after injury, depend on proper regulation of the expression levels of the pre- and post-synaptic proteins. We investigated the expression of four pre-synaptic proteins (growth-associated protein-43, synapsin-I, synaptophysin, and synaptotagmin) and two post-synaptic proteins (post-synaptic density protein-95 and Ca²⁺/calmodulin-dependent protein kinase II) in the hippocampus and cerebral cortex, respectively, in response to different treatments. Western blotting analysis showed that there were significant decreases in the expression of these representative synaptic proteins in the hippocampus and cerebral cortex of d-gal-treated mice. Interestingly, these decreased expression levels of synaptic proteins could be reversed by PSPC. The levels of expression of these representative synaptic proteins in mice treated with PSPC alone were not significantly different from those in untreated mice. The results of this study suggested that memory impairment and synaptic protein loss in d-gal-treated mice may be improved by treatment with PSPC.     

Treadmill exercise enhances passive avoidance learning in rats: the role of down-regulated serotonin system in the limbic system

While serotonin (5-HT) may impair learning and memory, exercise has been reported to improve them. Whether chronic exercise can facilitate fear memory via regulating the serotonin system is unknown. We examined the effects of 4-week treadmill exercise training on levels of 5-HT and its metabolite 5-hydroxyindoleacetic acid (5-HIAA), the protein expression of its receptor 5-HT_1A and transporter in the amygdala, hippocampus and prefrontal cortex of male Sprague–Dawley rats. Our results demonstrated that treadmill exercise (1) improved the passive avoidance learning performance; (2) decreased the 5-HT level in the hippocampus; (3) decreased the expression of 5-HT_1A receptor in the amygdala without altering the transporter expression. Moreover, pretreatment with 0.1 mg/kg 8-hydroxy-di-n-propylamino tetralin, a selective 5-HT_1A receptor agonist, impaired the passive avoidance performance and completely abolished the exercise-enhanced fear memory. Our results suggest that down-regulation of the 5-HT system in the limbic system, i.e., the reduction of the hippocampus 5-HT content and the amygdala 5-HT_1A receptor expression, may be involved in the exercise-enhanced fear memory.     

十七大精神与社会正义

十七大报告中八个地方专门提到公平正义的用语,并且明确指出,实现社会公平正义是中国共产党人的一贯主张,是发展中国特色社会主义的重大任务.报告中从社会发展一般目标到具体的制度体制设计对什么是社会主义初级阶段的公平正义的内涵和怎样达致公平正义的目标作了具有时代特征的科学阐释,具有重大的理论和实践意义.     

发散性思维的年龄差异及“位置法”记忆训练的作用

该研究的目的是探讨发散性思维的年龄差异以及“位置法”记忆训练对发散性思维的迁移作用。训练组为经过记忆训练的青年人24名,老年组20名,对照组为相匹配的青年人24名、老年人19名。结果表明:(1)在图形、符号、语义三方面的流畅性、变通性和独特性上,老年组均很显著地比青年组差。青年组的个别差异较大,老年组的更大,尤其是独特性。(2)青年训练组的图形流畅性、独特性及语义的独特性成绩显著优于其对照组,老年训练组图形的变通性有优于其对照组的趋势(P=.052),说明“位置法”记忆训练对发散性思维有一定的间接迁移作用,尤其是对青年人。(3)发散性思维与想象力、数字符号、训练前和训练后词的记忆以及图形的记忆成绩均有很显著正相关。而词汇成绩只与训练组两项发散性思维有显著相关。     

条件性味觉厌恶分化后臂旁核c-fos表达的变

以口内注入糖精或蔗糖溶液为条件刺激,腹腔内注射LiCl为非条件刺激,在大鼠形成条件性味觉厌恶后进行分化训练,观察味质和嗜好性对臂旁核各亚核c-fos表达的影响及其交互作用。结果表明：味质和嗜好性对背侧外侧亚核(dls)和腹侧外侧亚核(vls)的c-fos表达无影响;在内侧外侧亚核(ils)和外部内侧亚核(ems),蔗糖诱导的c-fos表达高于糖精,但在外部外侧亚核(els),糖精诱导的表达高于蔗糖;嗜好性刺激引起ils、中央外侧亚核(cls)和cms内c-fos高表达,厌恶性刺激引起ems和els内的高表达。在ils和cms嗜好性与味质的影响各自独立,在els和ems内嗜好性与味质的影响存在交互作用。提示PBN内存在味质辨别和报酬评价的代表区,两种代表区有交迭,ems和els对味质信息和报酬信息的整合有重要作用     

自动思维及归因方式对抑郁症作用的多因素分析

目的：探讨抑郁症患者治疗前后自动思维、应付方式变化对抑郁严重程度变化的影响及其相互作用。方法：对97例抑郁症患者分别在其入、出院时进行测评,测评工具包括自评抑郁量表、自动思维问卷和归因方式问卷。此外对100例正常对照亦进行上述测评,其中29例在15—20天后重测。结果：自动思维问卷得分、归因方式问卷得分的logistic回归分析、路径分析表明,自动思维、对正性事件的整体性维度的归因方式对抑郁程度的影响有显著作用,自动思维的变化对SDS的变化的直接影响最大(路径系数为0．572),归因方式中正性事件整体性归因的变化为其次(路径系数为一0．193),而自动思维的变化与归因方式中正性事件整体性归因的变化的相互影响较小(路径系数为-0．188)。结论：自动思维、对正性事件的整体性维度的归因方式对抑郁严重程度有显著影响。     

军人焦虑、忧郁情绪研究Ⅱ:主导因素及其交互作用

在研究Ⅰ中我们揭示了军人焦虑、忧郁情绪的基本状态,发现了影响因素,产提出因素间可能存在一定的交互作用,共同对情绪发生影响的假设。本研究在此基础上,着重对主导因素及因素间的交互作用进一步探索。结果发现,导致忧郁的主要因素为家庭因素即单亲家庭;其次为军龄,独生子女和成长环境（城市或农村）,环境与文化程度两因素的交互作用明显;导致焦虑的主要因素也为单亲家庭,其次为军龄,环境与文化程度两因素的我互作用同样     

虚拟所有权关系下的自我参照效应

通过两个实验,探讨了代词所确定的所有权关系对记忆的影响。实验1为2(参照条件:我的与他的)×3(报告类型:主试跟读、被试跟读与被试自己读)的混合设计,实验2为2(参照条件:我的与他的)×2(报告顺序:自己先报告与他人先报告)的被试内设计。实验中被试按相应的要求报告物品的所有权关系。结果发现,被试对自己的物品的回忆成绩显著高于对他人物品的回忆成绩,表现出所有权效应,说明即使由代词确定的虚拟所有权关系也对记忆有影响。     

文本阅读中背景信息的加工过程：激活与整合

采用移动窗口技术和眼动技术探讨了文本阅读中当前信息跟背景信息的具体加工过程。被试为华南师范大学本科生92名。实验1使用移动窗口技术,计算机屏幕上每次只呈现一个句子,让被试自己按键逐句进行阅读,通过分析不同实验条件下探测词的再认反应时间和不同实验条件下目标句的阅读时间来探讨文本阅读中信息加工的具体过程。实验2使用眼动技术在一种更自然的情境中通过分析不同实验条件下眼动指标的差异来进一步探讨文本阅读中信息加工的具体过程。实验结果表明,文本阅读中背景信息的加工过程包括激活和整合两个阶段,这两个阶段相互独立但又紧密联系,激活是整合发生的前提,有整合必先发生激活,但激活发生后并不一定会发生整合;文本阅读过程中读者阅读时间的延长主要发生在整合阶段     

作为哲学方法论的“本来性—现实性”——就荒木见悟《佛教与儒教》而谈

“本来性—现实性”是荒木见悟的一个重要哲学方法论,贯穿其整个中国哲学及佛学研究的过程。这一方法论观念既源自其对儒佛两教重要经典的创造诠释,更是源自其深刻的宗教体验、身心体验乃至战争期间的生命体验,最终在《佛教与儒教》中以“序论”的方式登场。在儒佛思想构造中,正如“本来成佛”或“本来圣人”所示,不论儒佛教说存有多大歧义,都表现出对这一本来性问题的终极关怀;出世间性的佛教对现实性问题亦并不缺乏关心,相反,以冷峻的目光正视现实性,透过现实性以肯定本来性,这是华严学特别是宗密哲学所关注的重点。儒教对本来性与现实性的理论建构更是其核心主题,如宋明儒学中的朱子学与阳明学。故超越儒佛宗派对立,以本来性与现实性的问题关切来整体审视儒佛两教乃至中国传统文化的思想智慧,进而为未来文化发展指明“现实本来性”的方向,具有重要的理论意义。