Stimulation of hippocampal adenylyl cyclase activity dissociates memory consolidation processes for response and place learning

Procedural and declarative memory systems are postulated to interact in either a synergistic or a competitive manner, and memory consolidation appears to be a highly critical stage for this process. However, the precise cellular mechanisms subserving these interactions remain unknown. To investigate this issue, 24-h retention performances were examined in mice given post-training intrahippocampal injections of forskolin (FK) aiming at stimulating hippocampal adenylyl cyclases (ACs). The injection was given at different time points over a period of 9 h following acquisition in either an appetitive bar-pressing task or water-maze tasks challenging respectively "response memory" and "place memory." Retention testing (24 h) showed that FK injection altered memory formation only when given within a 3- to 6-h time window after acquisition but yielded opposite memory effects as a function of task demands. Retention of the spatial task was impaired, whereas retention of both the cued-response in the water maze and the rewarded bar-press response were improved. Intrahippocampal injections of FK produced an increase in pCREB immunoreactivity, which was strictly limited to the hippocampus and lasted less than 2 h, suggesting that early effects (0-2 h) of FK-induced cAMP/CREB activation can be distinguished from late effects (3-6 h). These results delineate a consolidation period during which specific cAMP levels in the hippocampus play a crucial role in enhancing memory processes mediated by other brain regions (e.g., dorsal or ventral striatum) while eliminating interference by the formation of hippocampus-dependent memory.     

Default-mode network functional connectivity in aphasia: Therapy-induced neuroplasticity

Previous research on participants with aphasia has mainly been based on standard functional neuroimaging analysis. Recent studies have shown that functional connectivity analysis can detect compensatory activity, not revealed by standard analysis. Little is known, however, about the default-mode network in aphasia. In the current study, we studied changes in the default-mode network in subjects with aphasia who underwent semantic feature analysis therapy. We studied nine participants with chronic aphasia and compared them to 10 control participants. For the first time, we identified the default-mode network using spatial independent component analysis, in participants with aphasia. Intensive therapy improved integration in the posterior areas of the default-mode network concurrent with language improvement. Correlations between integration and improvement did not reach significance, but the trend suggests that pre-therapy integration of the default-mode network may predict therapy outcomes. Functional connectivity allows a better understanding of the impact of semantic feature analysis in aphasia.     

Stimulus–response translation in manual and vocal modality: Is age‐related slowing influenced by changes in working memory functioning?

In some conditions, age‐related slowing rates are higher for manual than for vocal responses. The interaction between age and response modality was examined in four experiments in which the performance of younger (M = 22.6 years) and older (M = 70.8 years) adults was compared under various stimulus–response mapping rules. The interaction effect was not observed in a simple localisation task on which the manual modality had an advantage in both age groups (Experiment 1). When congruence between stimulus and response was reduced (Experiment 2), manual responses were disproportionately slowed in older participants. In conceptual and size comparison tasks (Experiment 3), the age‐by‐modality effect was not influenced by working memory load during the interval between the first and the second stimulus presentation. In an identification task, age‐related slowing effects were less when responses were spoken names than when nonwords were used as labels (Experiment 4). These results indicate that older participants experience a specific difficulty in activating arbitrary S–R mapping rules during executive control.     

Effect of voice characteristics on the attended and unattended processing of two concurrent messages

Three experiments using dichotic listening measured the priming effect produced on the detection of a semantically defined target word in an attended list of words by a lexically identical word presented to the opposite ear with an attenuation of 12 dB. Experiment 1 embedded the prime in unattended continuous speech and found a 21 ms priming effect, but only when the voices of the two messages had different pitch ranges. Experiment 2 emphasised and generalised the priming effect to a more natural situation using voices differing both in pitch and timbre. This priming effect did not vary with word frequency. In Experiment 3 the prime was part of a list of isolated words played to the unattended ear. It found a 94 ms priming effect when there was no pitch-range difference between the two messages. This priming effect was larger for high-frequency words than for low. These results extend recent findings by Rivenez, Darwin, and Guillaume (2006) and demonstrate the importance of factors that influence perceptual organisation in determining the extent to which unattended messages can be processed.     

Impact of Motivational Climates on Claimed Self-Handicapping Strategies: Illustration in Tropical Environment

The purpose of the present study was to quantitatively and qualitatively examine whether claimed self-handicapping is increased in a performance motivational climate (PMC) compared with a mastery motivational climate (MMC) within a strictly controlled tropical environment. Participants completed measures of self-handicapping using open-ended questions before a physical test. The analyses revealed that (a) participants who engage in self-handicapping strategy were more numerous, (b) the number of self-handicap reported self-handicap score were greater, and (c) participants who engage in self-handicapping strategy reported more impediments in the PMC as compared with MMC. Information about the nature of self-handicapping claims is also provided.     

Middle School as a Developmental Niche for Civic Engagement

The present study investigated how school climate, school connectedness and academic efficacy beliefs inform emergent civic engagement behaviors among middle school youth of color. These associations were examined both concurrently and longitudinally using a developmentally appropriate measure of civic engagement. Data were drawn from two subsamples of a larger study of social/emotional development in middle school (cross‐sectional sample n = 324; longitudinal sample n = 232), M = 12 years old, 46 % female, 53 % male. Forty‐two percent (42.2 %) of the sample self‐identified as African American, 19.8 % as Multiracial or Mixed, 19.4 % as Latino, 11.6 % as Asian American or Pacific Islander, 11.6 % identified as Other, and 5.2 % as Native American. The study tested and found support for a latent mediation model in which more positive perceptions of school climate were positively related to school connectedness, and this in turn, was positively associated with civic engagement; school climate was also positively associated with academic‐self‐efficacy beliefs, but such beliefs did not mediate the climate‐civic engagement association. Implications for future research and practice are discussed.     

Speaking two languages at once: Unconscious native word form access in second language production

Bilingualism research has established language non-selective lexical access in comprehension. However, the evidence for such an effect in production remains sparse and its neural time-course has not yet been investigated. We demonstrate that German-English bilinguals performing a simple picture-naming task exclusively in English spontaneously access the phonological form of –unproduced– German words. Participants were asked to produce English adjective-noun sequences describing the colour and identity of familiar objects presented as line drawings. We associated adjective and picture names such that their onsets phonologically overlapped in English (e.g., green goat), in German through translation (e.g., blue flower – ‘blaue Blume’), or in neither language. As expected, phonological priming in English modulated event-related brain potentials over the frontocentral scalp region from around 440 ms after picture onset. Phonological priming in German was detectable even earlier, from 300 ms, even though German was never produced and in the absence of an interaction between language and phonological repetition priming at any point in time. Overall, these results establish the existence of non-selective access to phonological representations of the two languages in the domain of speech production.     

Dyadic Cross-Sectional Associations Between Negative Mood,Marital Idealization,and Relationship Quality

This study aimed to evaluate (a) dyadic associations between relationship quality (RQ) and both depressive and anxious mood (DM and AM), (b) reciprocity hypotheses of negative mood within dyadic interactions, and (c) mediational role of marital idealization between negative mood and relationship quality. Actor-partner interdependence models (APIMs) were performed using data from a sample of 198 dyads. Our results showed that (a) these two facets of negative mood did not have the same weight on RQ and that they had a gender-specific effects pattern, and (b) there was no support for the mood transmission hypothesis. Men's DM displayed direct and indirect (via marital idealization) actor as well as partner effects on RQ, whereas women's DM displayed only a direct actor effect on RQ. There were no significant direct actor effects of AM on RQ, meaning that this link is fully mediated by marital idealization. However, only women's AM showed such indirect effects on RQ.     

Children's memory distortions following social contact with a co-witness: Disentangling social and cognitive mechanisms

This study examined whether recalling an event with a co-witness influences children's recall. Individual 3-5-year-olds (n = 48) watched a film with a co-witness. Unbeknown to participants, the co-witness was watching an alternative version of the film. Afterwards both the co-witness and the participant answered questions about the film together (public recall), and the degree to which children conformed to the co-witness's alternative version of events was measured. Subsequently participants were questioned again individually (private recall). Children also completed false belief and inhibitory control tasks. By separating errors made in public and private, the results indicated that both social conformity (32% of errors) and memory distortion (68% of errors) played a role in co-witness influence. Inhibitory control predicted the likelihood of retracting errors in private, but only for children who failed (r=.66) rather than passed false belief tasks (r=-.10). The results suggest that children with a theory of mind conform in the company of the co-witness to avoid social embarrassment, while those a poor theory of mind conform on the basis of an inability to inhibit the co-witness's response. The findings contribute to our understanding of the motivations responsible for co-witness conformity across early childhood.