Online Module for Carrier Screening in Ashkenazi Jewish Individuals Compared with In-Person Genetics Education: A Randomized Controlled Trial

To increase accessibility to genetics services for low-urgency patients seeking Ashkenazi Jewish (AJ) carrier screening, we designed an interactive computer (IC) module that provides pre-test genetics education and allows genetics professionals to order the test without meeting the patients beforehand. We compared this module with in-person genetic counseling (GC) using a randomized trial. AJ individuals were randomized to undergo genetics education via the IC module (n = 26) or GC (n = 28). We compared post-interventional genetics knowledge, perceived genetic risk, and anxiety between the two groups, after accounting for pre-interventional scores, using ANCOVA. Wilcoxon Rank-Sum test was used to compare post-interventional satisfaction. Post-interventional genetics knowledge, risk perception, or anxiety were not significantly different between the two groups after accounting for baseline scores (p = 0.50–0.54), although the data are inconclusive regarding the module’s non-inferiority at a 5% margin. Post-intervention satisfaction scores were generally higher in the GC group than the IC module group. Our IC module has the potential to improve access to clinical genetics services for patients and staff, but it is not suitable for all AJ patients and cannot completely replace the benefits of in-person consultations.     

Implicit attitudes and the improvement of exercise capacity during pulmonary rehabilitation

The aim of this study was to examine the role of explicit and implicit attitudes in the improvement of exercise capacity during a 5-week pulmonary rehabilitation (PR). A total of 105 patients performed walking tests at baseline and at the end of PR. Change between performances was computed at the end of PR, and Minimal-Clinically-Important-Difference (MCID) were used to categorize patients as responders (i.e. change above MCID, N = 54) or non-responders (i.e. change below MCID, N = 51). At baseline, implicit attitudes were measured through a physical activity versus sedentary behavior Implicit Association Test; explicit attitudes toward physical activity and sedentary behavior were measured by questionnaires. Only implicit attitudes significantly differed between the two groups (p = .015), responders displaying implicit attitudes significantly more in favor of physical activity (M = .91, SD = .54) than non-responders (M = .60, SD = .71) at baseline. Measuring implicit attitudes in PR could help to accurately estimate patients’ motivation, and design more individualized rehabilitation programs.     

Antiferromagnetic order and the structural order–disorder transition in the Cd6Ho quasicrystal approximant

It has generally been accepted that the orientational ordering of the Cd₄ tetrahedron within the Cd₆ R quasicrystal approximants is kinetically inhibited for R?=?Ho, Er, Tm and Lu by steric constraints. Our high-resolution X-ray scattering measurements of the Cd₆Ho quasicrystal approximant, however, reveal an abrupt (first-order) transition to a monoclinic structure below T _S?=?178?K for samples that have ‘aged’ at room temperature for approximately one year, reopening this question. Using X-ray resonant magnetic scattering at the Ho L ₃-edge we have elucidated the nature of the antiferromagnetic ordering below T _N?=?8.5?K in Cd₆Ho. The magnetic Bragg peaks are found at the charge forbidden H?+?K?+?L?=?2n?+?1 positions, referenced to the high-temperature body-centred cubic structure. In general terms, this corresponds to antiferromagnetic arrangements of the Ho moments on adjacent clusters in the unit cell as previously found for Cd₆Tb.     

When motion improves working memory

ABSTRACT

In the present study, we used a complex span task to explore how memory traces resulting from Self-Performed Task (SPT) and Verbal Task (VT) are maintained in working memory. Participants memorised series of five sentences describing an action either through SPT or VT. Between pairs of sentences, participants performed a concurrent task that varied according to its nature and its cognitive load. The concurrent task was either a verbal task, a low cognitive load motor task or a high cognitive load motor task. A control condition served as a baseline. First, we observed that performance in SPT and VT did not decrease with verbal or motor suppression, but was lower with an increase of the cognitive load. This suggests that memory traces are maintained through attentional refreshing whatever the encoding (SPT or VT). Second, while the enactment effect was replicated in the control condition, it tended to vanish with a verbal concurrent task; moreover, it was reversed with motor concurrent tasks. Surprisingly, the latter effect resulted from an increase of VT memory performance when participants repeated the same gesture between sentences. Finally, our results provide additional evidence that the enactment effect does not rely on attention.     

An Internal Version of Epistemic Logic

Representing an epistemic situation involving several agents obviously depends on the modeling point of view one takes. We start by identifying the types of modeling points of view which are logically possible. We call the one traditionally followed by epistemic logic the perfect external approach, because there the modeler is assumed to be an omniscient and external observer of the epistemic situation. In the rest of the paper we focus on what we call the internal approach, where the modeler is one of the agents involved in the situation. For this approach we propose and axiomatize a logical formalism based on epistemic logic. This leads us to formalize some intuitions about the internal approach and about its connections with the external ones. Finally, we show that our internal logic is decidable and PSPACE-complete.     

Scene perception, gaze behavior, and perceptual learning in virtual environments.

More and more immersive environments are developed to provide support for learning or training purposes. Ecological validity of such environments is usually based on learning performance comparisons between virtual environments and their genuine counterparts. Little is known about learning processes occurring in immersive environments. A new technique is proposed for testing perceptual learning during virtual immersion. This methodology relies upon eye-tracking technologies to analyze gaze behavior recorded in relation to virtual objects' features and tasks' requirements. It is proposed that perceptual learning mechanisms engaged could be detected through eye movements. In this study, nine subjects performed perceptual learning tasks in virtual immersion. Results obtained indicated that perceptual learning influences gaze behavior dynamics. More precisely, analysis revealed that fixation number and variability in fixation duration varied with perceptual learning level. Such findings could contribute in shedding light on learning mechanisms as well as providing additional support for validating virtual learning environments.     

Speech-specific auditory processing: where is it?

Are speech-specific processes localized in dedicated cortical regions or do they emerge from developmental plasticity in the connections among non-dedicated regions? Here we claim that all the brain regions activated by the processing of auditory speech can be re-classified according to whether they respond to non-verbal environmental sounds, pitch changes, unfamiliar melodies, or conceptual processes. We therefore argue that speech-specific processing emerges from differential demands on auditory and conceptual processes that are shared by speech and non-speech stimuli. This has implications for domain- vs. process-specific cognitive models, and for the relative importance of segregation and integration in functional anatomy.