Spermine improves recognition memory deficit in a rodent model of Huntington’s disease

Huntington’s disease (HD) is a progressive neurodegenerative disorder associated with motor and cognitive impairment. Intrastriatal administration of quinolinic acid (QA) causes neurodegeneration, glial proliferation and cognitive impairment in animals, which are similar to these seen in human HD. Since polyamines improve memory in cognitive tasks, we now tested if the post-training intrastriatal administration of spermine, an agonist of the polyamine site at the NMDA receptor, reverses the deficits in the object recognition task induced by QA. Bilateral striatal injections of QA (180 or 360 nmol/site) caused object recognition impairment, neuronal death and reactive astrogliosis. A single injection of spermine (0.1 and 1 nmol/site), 5 days after QA injection, reversed QA-induced impairment of object recognition task. Spermine (0.1 nmol/site) also inhibited QA-induced reactive astrogliosis measured by a semi-quantitative determination of GFAP immunolabelling, but did not alter neuronal death, measured by a semi-quantitative determination of fluoro-Jade C staining. These results suggest that polyamine binding sites may be considered a novel therapeutic target to prevent reactive astrogliosis and mnemonic deficits in HD.     

The effect of maternal employment on adolescent daughters

This report considers the question of the effects of maternal employment on adolescents. The frequently cited conclusion that there is "no difference between the adolescents of employed and nonemployed mothers" is considered inaccurate. It is argued that failure to find differences between these two groups does not mean that there are no differences. Comparisons of personal relationships within the family context showed that daughters of nonemployed mothers had a closer relationship with their fathers, perceived them as happier and more friendly, and experienced less anger and tension in the home.     

The effects of metabolic stress and vagotomy on emotional learning in an animal model of anxiety

The aim of the present study is to evaluate the role of the blood glucose (BG) level in emotional learning in the elevated plus maze (EPM), an animal model of anxiety. In Experiment 1, male Wistar rats were submitted to different EPM trial lengths (1- or 5-min). Blood samples were withdrawn before and after the maze exploration, through a polyethylene cannula chronically implanted into the jugular vein. In Experiment 2, the animals received either saline or 2-deoxy-D-glucose, a glucoprivic drug (2-DG, 250 or 500 mg kg(-1)) by i.p. route, 30 min before a 5-min EPM exposure and were retested in the maze (Trial1/Trial2 EPM procedure) 24 h later. In an independent group of rats, blood samples were withdrawn 0, 5, 15, and 30 min after 2-DG administration, through the jugular vein, to determine BG. In Experiment 3, the animals underwent a vagotomy and were tested in a Trial1/Trial2 EPM procedure four weeks later. The results showed that rats exploring the EPM for 5 min displayed increased fear and higher hyperglycemia than those exploring the EPM for 1 min. In addition, rats submitted to 5-min EPM Trial1 length displayed higher level of fear on Trial2, as well as higher percentage of shortening of the %Open arm entries and %Open arm time from Trial1 to Trial2, which characterizes the occurrence of emotional learning. In contrast, rats previously vagotomized or treated with 2-DG (500 mg kg(-1)) showed the same level of fear on both EPM trials and a low percentage of shortening, from Trial1 to Trial2, of the %Open arm entries and %Open arm time, indicating poor emotional learning. The data is discussed regarding the role of glycaemia in emotional learning in the EPM.     

Relative age effect in Olympic Taekwondo athletes

Relative age effects refer to the effects of age differences among individuals who have been grouped together for a performance activity. This study aimed to investigate the relative age effect on Olympic Taekwondo athletes, in several Olympic Games, and in both sexes. The study sample consisted of 291 athletes who had competed in Atlanta, Sydney, and Beijing Olympic Games. The relative age effect was examined for the general distribution of athletes by quartile, for each of the individuals, and for male and female athletes. There were no discernable effects of relative age on Olympic Taekwondo athletes.     

Polyaminergic agents modulate contextual fear extinction in rats

Polyamines, such as spermidine and spermine, have been reported to improve memory retention through the activation of N-methyl-d-aspartate receptors (NMDAr). However whether polyamine agonists and antagonists alter extinction remains unclear. In the current study, we investigated whether spermidine and polyamine antagonists that selectively block the NR2B subunit at the NMDAr alter the extinction of contextual conditioned fear in male Wistar rats. The bilateral intra-hippocampal administration of exogenous spermidine (2 nmol/site) immediately after, but not 6 h after extinction training, facilitated the extinction of fear conditioning. The injection of the NMDAr antagonists arcaine (0.2 nmol/site), ifenprodil (20 nmol/site) and traxoprodil (0.2 nmol/site), disrupted fear extinction and, at doses that had no effect per se, reversed the facilitatory effect of spermidine on fear extinction. These results suggest that exogenous and endogenous polyamines facilitate the extinction of contextual conditioned fear through activation of NR2B subunit-containing NMDAr in the hippocampus. Since extinction-based exposure therapy is widely used as treatment for a number of anxiety-related disorders, including phobias and post-traumatic stress, the currently reported facilitation of extinction by polyaminergic agents suggest these compounds as putative candidates for drug development.     

Is Weiner's attribution‐help model stable across cultures? A test in Brazilian subcultures

The effect of attribution of responsibility on the intention to help is a well‐studied effect. The Weiner model of attribution‐emotion‐help is the main theoretical development to describe the structural relation between these variables. Some research results have suggested that culture influences the relation between model variables. Collectivists tend to show more compassionate emotions independent of attribution of responsibility whereby emotion is no longer a mediator. The present research aims to test the Weiner model in Brazil, a country with established subcultures and clear distinctions in the collectivism–individualism dimension across its regions. An experiment with 1,569 participants from all five Brazilian regions was conducted. Path analysis revealed that more socially oriented participants tended to feel more compassion for the experimental scenario's protagonist, independent of controllability manipulation, decreasing the effect of emotions in the model. These results depict the effect of culture on the model, questioning the stability of the model across cultures.     

Final Insults & Other Family Matters

We didn't want to put her in a nursing home. Until the last minute, and even after that, we believed it could be otherwise. I'd plan to fly Mom down to stay with me. I painted the guest room and made lace curtains. My sister mentally arranged and rearranged the furniture in her apartment, converting the livingroorn into a bedroom for Mom. But in the end, our mother's dying overwhelmed us. She was so difficult, so unhappy to be dying, and not about to impart: words of wisdom and comfort from her deathbed. The medication, Dilaudid, made her very dark, like she used to get on alcohol. Mean things bubbled out of her mouth. When I came to take her home after her second stay in the hospital, she frowned at me and said, “You're not even the person I want to see.” I found it hard to believe it was just the drugs speaking.     

The Processing of Grammatical Gender Agreement in Brazilian Portuguese: ERP Evidence in Favor of a Single Route

Journal of Psycholinguistic Research - The present study used event-related potentials to investigate whether the processing of grammatical gender agreement involving gender regular and irregular...     

Are There Cross-Cultural Legal Principles? Modal Reasoning Uncovers Procedural Constraints on Law

Despite pervasive variation in the content of laws, legal theorists and anthropologists have argued that laws share certain abstract features and even speculated that law may be a human universal. In the present report, we evaluate this thesis through an experiment administered in 11 different countries. Are there cross-cultural principles of law? In a between-subjects design, participants (N = 3,054) were asked whether there could be laws that violate certain procedural principles (e.g., laws applied retrospectively or unintelligible laws), and also whether there are any such laws. Confirming our preregistered prediction, people reported that such laws cannot exist, but also (paradoxically) that there are such laws. These results document cross-culturally and –linguistically robust beliefs about the concept of law which defy people's grasp of how legal systems function in practice.     

Learning Behavioral Repertoires with Different Consequences Hinders the Interconnection of These Repertoires in Pigeons in the Box Displacement Test

The Psychological Record - The interconnection of repertoires is a behavioral process related to problem solving and creativity. Experiments on this topic have mostly used a single reinforcer type...