A transdiagnostic examination of decreased intolerance of uncertainty and treatment outcome

Intolerance of uncertainty (IU) is characterized by negative beliefs and reactions to uncertainty. IU is present in emotional disorders and may be a mechanism of change in treatment . There are two components of IU, prospective and inhibitory IU, that may be differentially associated with outcome. The current study tested associations between pre- and post-treatment changes in the components of IU, symptoms of anxiety and depression, and treatment outcome in a large diagnostically heterogeneous partial hospital sample. Results suggested that social anxiety disorder was associated with greater pre-treatment prospective and inhibitory IU scores than those without the diagnosis. Results also showed that inhibitory IU predicted change in anxiety and depression symptoms and prospective IU and depression reductions predicted improvements in overall psychological health and psychological inflexibility. Only change in depression predicted improvement in interpersonal relationships throughout treatment. Clinical and theoretical implications of the findings are discussed.     

Precaution or Integrated Responsibility Approach to Nanovaccines in Fish Farming? A Critical Appraisal of the UNESCO Precautionary Principle

Nanoparticles have multifaceted advantages in drug administration as vaccine delivery and hence hold promises for improving protection of farmed fish against diseases caused by pathogens. However, there are concerns that the benefits associated with distribution of nanoparticles may also be accompanied with risks to the environment and health. The complexity of the natural and social systems involved implies that the information acquired in quantified risk assessments may be inadequate for evidence-based decisions. One controversial strategy for dealing with this kind of uncertainty is the precautionary principle. A few years ago, an UNESCO expert group suggested a new approach for implementation of the principle. Here we compare the UNESCO principle with earlier versions and explore the advantages and disadvantages by employing the UNESCO version to the use of PLGA nanoparticles for delivery of vaccines in aquaculture. Finally, we discuss whether a combined scientific and ethical analysis that involves the concept of responsibility will enable approaches that can provide a supplement to the precautionary principle as basis for decision-making in areas of scientific uncertainty, such as the application of nanoparticles in the vaccination of farmed fish.     

Achievement motives and emotional processes in children during problem-solving: Two experimental studies of their relation to performance in different achievement goal conditions

In two studies, the influence of key emotional and motivational factors on performance in different achievement goal-type situations is examined. In study 1, based on 314 sixth-graders, two types of goal situations were induced; performance and mastery. The goals were examined with respect to important antecedents (e.g., motive dispositions) and several consequences (e.g., performance, satisfaction, pleasant affect, worry, and emotionality). The results showed that the motive to achieve success (M _s) produced positive affects, satisfaction, and increased performance, whereas the motive to avoid failure (M _f) produced worries and performance reduction. In study 2, based on 331 sixth-graders, three types of goal situations were induced; performance–approach, performance–avoidance, and mastery goals. The findings revealed that the most important single factors positively related to performance were M _s and mastery–goal situation. In addition, high M _s pupils performed better under mastery condition than under performance condition. Finally, avoidance-goal situation accentuate the negative effects of high M _f on performance.     

Sensitivity to spacing changes in faces and nonface objects in preschool-aged children and adults

Sensitivity to variations in the spacing of features in faces and a class of nonface objects (i.e., frontal images of cars) was tested in 3- and 4-year-old children and adults using a delayed or simultaneous two-alternative forced choice matching-to-sample task. In the adults, detection of spacing information was robust against exemplar differences for faces but varied across exemplars for cars (Experiment 1A). The 4-year-olds performed above chance in both face and car discrimination even when differences in spacing were very small (within ±1.6 standard deviations [SDs]) and the task involved memory components (Experiment 1B), and the same was true for the 3-year-olds when tested with larger spacing changes (within ±2.5 SDs) in a task that posed no memory demands (Experiment 2). An advantage in the discrimination of faces over cars was found at 4 years of age, but only when spacing cues were made more readily available (within ±2.5 SDs). Results demonstrate that the ability to discriminate objects based on feature spacing (i.e., sensitivity to second-order information) is present at 3 years of age and becomes more pronounced for faces than cars by 4 years of age.     

Emotion processing facilitates working memory performance

The effect of emotional stimulus content on working memory performance has been investigated with conflicting results, as both emotion-dependent facilitation and impairments are reported in the literature. To clarify this issue, 52 adult participants performed a modified visual 2-back task with highly arousing positive stimuli (sexual scenes), highly arousing negative stimuli (violent death) and low-arousal neutral stimuli. Emotional stimulus processing was found to facilitate task performance relative to that of neutral stimuli, both in regards to response accuracy and reaction times. No emotion-dependent differences in false-alarm rates were found. These results indicate that emotional information can have a facilitating effect on working memory maintenance and processing of information.     

A self-help book is better than sleep hygiene advice for insomnia: a randomized controlled comparative study

The objective was to compare the effects of two types of written material for insomnia in a randomized trial with follow-up after three months. Insomniacs were recruited through newspaper advertisements to a web-based survey with validated questionnaires about sleep, anxiety, depression, and use of sleep medications. A self-help book focusing on cognitive behavioral therapy for insomnia was compared to standard sleep hygiene advice; 77 and 78 participants were randomized to self-help book or sleep hygiene advice, respectively. The response rate was 81.9%. The self-help book gave significantly better scores on the sleep questionnaires compared to sleep hygiene advice. The proportion using sleep medications was reduced in the self-help book group, whereas it was increased in the sleep hygiene group. Compared to pre-treatment, the self-help book improved scores on the sleep (effect sizes 0.61-0.62) and depression (effect size 0.18) scales, whereas the sleep hygiene advice improved scores on some sleep scales (effect sizes 0.24-0.28), but worsened another (effect size -0.36). In addition, sleep hygiene advice increased the number of days per week where they took sleep medications (effect size -0.50). To conclude, in this randomized controlled trial, the self-help book improved sleep and reduced the proportion using sleep medications compared to sleep hygiene advice. The self-help book is an efficient low-threshold intervention, which is cheap and easily available for patients suffering from insomnia. Sleep hygiene advice also improved sleep at follow-up, but increased sleep medication use. Thus, caution is warranted when sleep hygiene advice are given as a single treatment.     

Improved effectiveness of cueing by self‐explanations when learning from a complex animation

A major problem in learning from instructional animations is that the complex perceptual and cognitive processing exceeds the learner's limited processing capacities. Although attention cueing might help learners in focusing on essential parts of an animation, previous studies have shown that it does not necessarily improve learning performance. This study investigated whether generating self‐explanations while studying a cued or an uncued animation might engage learners in cognitive activities necessary for learning. It was hypothesized that learning from a cued animation that reduces working memory load associated with searching for specific elements might be improved by generating self‐explanations, whereas self‐explaining with an uncued animation would have no positive effect on learning. The results confirmed the hypothesized interaction between cueing and self‐explaining. They suggest that self‐explanation enhances learning if visual cues are used to structure and highlight the essential parts of an animation. Copyright © 2010 John Wiley & Sons, Ltd.     

Lüdecke C,Sachsse U,Faure H (2010) Sucht – Bindung – Trauma: Psychotherapie von Sucht und Traumafolgen im neurobiologischen Kontext

Buchbesprechungen

Lüdecke C, Sachsse U, Faure H (2010) Sucht – Bindung – Trauma: Psychotherapie von Sucht und Traumafolgen im neurobiologischen Kontext Schattauer, Stuttgart, 364 S., ISBN-13: 978-3794527465, EUR 49,95     

Cognitive Differences Between Patients with Left-sided and Right-sided Parkinson’s Disease. A Review

At disease onset, patients with Parkinson’s disease (PD) typically report one side of the body to be more affected than the other. Previous studies have reported that this motor symptom asymmetry is associated with asymmetric dopaminergic degeneration in the brain. Research on the cognitive repercussions of this asymmetric degeneration has yielded inconsistent results. Here, we review studies that reported on the cognitive performance of patients with left-sided (LPD) or right-sided (RPD) motor symptom predominance. We present evidence that patients with RPD typically experience problems with language-related tasks and verbal memory, whereas patients with LPD more often perform worse on tasks of spatial attention, visuospatial orienting and memory and mental imagery. In general, no differences were found between both groups on tasks measuring attention and executive function. The association between motor asymmetry and cognitive performance indicates that PD does not lead to one typical cognitive profile. The effect of symptom laterality on the cognitive complaints should be considered in the assessment and treatment of each individual patient.     

Executive function tests in early‐onset psychosis: which one to choose?

People with schizophrenia exhibit executive functioning deficits, an area well investigated in the adult onset schizophrenia (AOS) group, but far less so in early-onset schizophrenia (EOS). Since EOS in general seems to exhibit poorer cognitive functions and is clinically more compromised than AOS, choice of efficient and sensitive assessment measures is not necessarily the same within the two groups. The MATRICS Consensus Cognitive Battery was developed for adults when studying treatment effects and uses Mazes (Neuropsychological Assessment Battery [NAB]) to assess executive functioning. We tested 31 adolescents with schizophrenia spectrum disorders and 66 healthy controls in order to examine how Mazes compares to two other commonly used tests to measure executive functioning, D-KEFS Color Word Interference Test (Stroop) and the Wisconsin Card Sorting Test (WCST). Significant discriminating power was found for all three measures. Patients performed 0.8-1.5 SD below controls with Stroop as the most sensitive measure, followed by Mazes and WCST. Mazes was selected by the MATRICS to assess treatment effects in AOS and is shown to be able. We find the instrument also able to separate adolescent patients from controls and thus, it appears a sensible choice in clinical settings. If a more elaborated neuropsychological evaluation of the executive functioning domain is needed, Stroop should be considered a complementary test.