Role of the striatal cholinergic system in the regulation of learned manipulation in rats

The experiments were performed on adult Wistar male rats trained to push with the forepaw on a fixed piston inside a narrow tube. It was found that after localized intracerebral injection of a cholinergic antagonist into the dorso-lateral (but not medial) neostriatum (i.e., the caudato-putamen) the behavioral performance requiring brief innate movements remained unchanged, but the performance requiring a prolonged pushing movement (> 50 msec) became disrupted. Microinjection of carbacholine (0.03-3 μ g/1 μ1) did not affect the performance of the acquired movements, whereas scopolamine (3 μ g/1 μ1) led to the significant decrease in pushing time. We conclude that changes in the state of the dorso-lateral neostriatal cholinergic system result only in disturbances of the sensory-controlled component of a complex instrumental movement. The 1994 Pavlovian Society Young Investigator Awardee was Nadezda Dubrovskaya, first author of this paper, which was presented at the annual meeting of the Pavlovian Society, July 3, 1994, in Prague, Czech Republic.     

The Suicidal Narrative and Its Relationship to the Suicide Crisis Syndrome and Recent Suicidal Behavior

In this study, we introduce the construct of the suicidal narrative, a hypothetical personal narrative linked to imminent suicide, and explore its relationship to near‐term suicidal risk and the suicide crisis syndrome (SCS). Psychiatric outpatients (N = 289) were administered the Columbia Suicide‐Severity Rating Scale (C‐SSRS), Suicide Crisis Inventory (SCI), and Suicide Narrative Inventory (SNI), a novel instrument combining the documented risk factors of Thwarted Belongingness, Perceived Burdensomeness, Humiliation, Social Defeat, Goal Disengagement, and Goal Reengagement. Dimensional measures of past month, lifetime, and past suicidal phenomena, incorporating ideation and behavior, were calculated from the C‐SSRS. Structural equation modeling was used to explore the interaction among variables. Factor analysis of the SNI yielded two orthogonal factors, termed Interpersonal and Goal Orientation. The former factor was comprised of Perceived Burdensomeness, Social Defeat, Humiliation, and Thwarted Belongingness, the latter of Goal Disengagement and Goal Reengagement. The Interpersonal factor correlated with both SCS severity and suicidal phenomena in each time frame and the Goal Orientation factor with no other variable. As hypothesized, the proposed model was significant for the past month only. Our findings support the construct of the suicidal narrative and its function as a near‐term suicidal risk factor.     

Determinants and Predictive Value of Clinician Assessment of Short‐Term Suicide Risk

We examine the interrelations among clinicians' judgment of patients' suicide risk, clinicians' emotional responses, and standard risk factors in the short‐term prediction of suicidal thoughts and behaviors. Psychiatric outpatients (n = 153) with a lifetime history of suicide ideation/attempt and their treating clinicians (n = 67) were evaluated at intake. Clinicians completed a standard suicide risk instrument (modified SAD PERSONS scale), a 10‐point Likert scale assessment of judgment of patient suicide risk (Clinician Prediction Scale), and a measure of their emotional responses to the patient (Therapist Response Questionnaire‐Suicide Form). The Columbia Suicide Severity Rating Scale and the Beck Scale for Suicide Ideation were administered at a one‐month follow‐up assessment (n = 114, 74.5%). Clinician judgment of risk significantly predicted suicidal thoughts and behaviors at follow‐up. Both the standard suicide risk instrument and clinician emotional responses contributed independently to the clinician assessment of risk, which, in turn, mediated their relationships with suicidal thoughts and behaviors. Our findings validate the importance of clinical judgment in assessing suicide risk. Clinical judgment appears to be informed both by concrete risk factors and clinicians' emotional responses to suicidal patients, highlighting emotional awareness as a promising area for research and training.     

Correction to: Lambek Calculus with Conjugates

Studia Logica - We, the authors, would like to thank Guillaume Aucher for informing us of his “Displaying Updates in Logic”, published in the Journal of Logic and Computation,...     

The Croatian version of the Emotion Regulation Questionnaire: Links with higher- and lower-level personality traits and mood

The Emotion Regulation Questionnaire (ERQ) measures habitual use of two emotion regulation strategies, cognitive reappraisal and expressive suppression. The present study tested the psychometric properties and validity of a newly developed Croatian adaptation of the ERQ. In a sample of 347 participants, we first sought to confirm the ERQ's original factor structure. Next, we tested its convergent, divergent and incremental validity. In the first subsample (N = 140), we linked the ERQ with a measure of the Five-Factor Model dimensions and their facets (Revised NEO Personality Inventory). In the second subsample (N = 207), we tested its ability to predict personality dimensions assessed by a different measure (Big Five Inventory) as well as the traits of positive and negative affect, including its incremental validity in predicting the latter. The results corroborated earlier findings, showing that the Croatian ERQ has equivalent psychometrics and predictive validity as ERQs in other languages. Crucially, the observed links between the ERQ and the facets of the Five-Factor Model dimensions enrich our understanding of the personality mechanisms behind the employment of these emotion regulation strategies.     

Decreased levels of N-acetylaspartate in dorsolateral prefrontal cortex in a case of intractable severe sympathetically mediated chronic pain (complex regional pain syndrome,type I)

In our previous in vivo proton magnetic resonance spectroscopy ((1)H MRS) study we found reduced levels of N-acetylaspartate in dorsolateral prefrontal cortex of chronic back pain patients. This study tests whether these chemical abnormalities can be detected in other pain states. Using (1)H MRS, we measured levels for N-acetylaspartate and other identifiable chemicals relative to creatine in four bilateral brain regions, including dorsolateral prefrontal cortex, orbitofrontal cortex, cingulate, and thalamus, in a case of intractable severe sympathetically mediated chronic pain [complex regional pain syndrome (CRPS) type I]. The subject's chemical variations in the brain were compared to the same regional chemicals in 10 normal subjects (age- and sex-matched). Univariate statistics showed reduced levels of N-acetylaspartate in bilateral dorsolateral prefrontal cortex and increased levels of myo-inositol in left orbitofrontal cortex of the patient with intractable severe CRPS type I. These data support our original hypothesis that depletion of N-acetylaspartate in dorsolateral prefrontal cortex is a chemical marker of chronic pain, indicating for neuronal degeneration. Unpredicted changes of orbitofrontal myo-inositol may be related to the specific mood/affective state in an extreme pain perception. This is the first report, which identifies chemical markers in the prefrontal cortex for objective measurement and monitoring of CRPS type I. This information might lead to valuable insights into diagnosis and future effective interventions of CRPS type I (e.g., prefrontal brain stimulation).     

A Principled Solution to Fitch’s Paradox

To save antirealism from Fitchs Paradox, Tennant has proposed to restrict the scope of the antirealist principle that all truths are knowable to truths that can be consistently assumed to be known. Although the proposal solves the paradox, it has been accused of doing so in an ad hoc manner. This paper argues that, first, for all Tennant has shown, the accusation is just; second, a restriction of the antirealist principle apparently weaker than Tennants yields a non-ad hoc solution to Fitchs Paradox; and third, the alternative is only apparently weaker than, and even provably equivalent to, Tennants. It is thereby shown that the latter is not ad hoc after all.     

Causation, Principle of Common Cause and Theoretical Explanation: Wesley C. Salmon and G. W. F. Hegel

The aim of this article is to analyze the main contributions of Wesley C. Salmon to the philosophy of science, that is, his concepts of causation, common cause, and theoretical explanation, and to provide a critique of them. This critique will be based on a comparison of Salmon??s concepts with categories developed by Hegel in his Science of Logic, and which can be applied to the issues treated by Salmon by means of the above given three concepts. It is the author??s contention that by means of Hegelian categories it becomes possible to provide a critique of Salmon??s philosophy of science and at the same time to enlarge the concept framework of philosophy of science.