Treating survivors of the World Trade Center terrorist attacks of September 11, 2001

As part of an established traumatic stress research and treatment program located in New York City, we experienced the September 11, 2001, terrorist attacks on the World Trade Center first as New Yorkers, but also as professionals with an interest in both treating the survivors and furthering scientific knowledge regarding the neurobiology and treatment of traumatic stress. This paper gives vignettes of calls to our program and the treatment of World Trade Center terrorist attack survivors.     

A rule-based categorization deficit in Alzheimer's disease?

This study examined the categorization processes that Alzheimer's disease (AD) patients use during assessments of semantic memory. Rule-based categorization involves the careful, analytic processing of strict criteria to determine category membership, particularly for items from graded categories with ambiguous category membership; similarity-based categorization requires an overall comparison of a test stimulus with a prototype or remembered exemplar of the category and is relatively effective for the rapid categorization of items with unambiguous category membership. To assess these processes in AD, patients were asked to decide the category membership of test stimuli for categories with poorly defined or fuzzy boundaries (e.g., VEGETABLE) and for categories with well-defined boundaries (e.g., FEMALE) and then to judge the representativeness of the test stimulus for its chosen category. A subgroup of AD patients demonstrated a typical pattern of impaired semantic memory compared to healthy control subjects; that is, difficulty deciding the category membership of test items from fuzzy categories. Among these patients, we found no deficit in category membership decisions about items taken from well-defined categories. We also found that AD patients and healthy controls do not differ in their representativeness judgments of items within a correctly judged category. These findings are most consistent with the hypothesis that rule-based categorization difficulty limits semantic memory in AD.     

Sensitivity of MMPI Validity Scales to Motivational Factors in Psychological Evaluations of Police Officers

To examine whether Minnesota Multiphasic Personality Inventory (MMPI) validity scales are sensitive to motivational sets in a specific forensic population, we compared three groups of 20 police officers being evaluated for fitness to return to duty: those who expressed a desire to return; those desiring not to, and a control group. Results indicate that four validity indices Significantly differentiated experimental groups in the expected directions. Officers wanting to return to duty minimized psychological difficulties significantly more than the other groups. Thus, our study supports the usefulness of MMPI validity scales in assessing response bias in police fitness evaluations. Data suggest that minimization occurs primarily for obvious emotional or characterological problems.     

Khandwalla's protocol analysis

E. H. Gombrich (1909–2001) was almost certainly the most broadly known art historian of the 20th century, and his scholarly work has influenced researchers in many domains. Among psychologists, Gombrich's impact has been greatest in the area of visual perception, largely through the ideas articulated in his book Art and Illusion (1960). His influence on creativity research has been far less profound, although his writings include numerous (although often indirect) discussions of fundamental aspects of creative processes. This cognitive–historical case study investigation aimed to understand how Gombrich achieved a rich, and sometimes prescient, understanding of creativity without emphasizing it as an explicit focus of his scholarship. I argue that Gombrich's cognitive style and multidisciplinary forays led him to emphasize and integrate a particular set of principles that are often underemphasized in contemporary creativity research. Gombrich's foci, on understanding individual creators, continuity with tradition, expert knowledge, feedback, evaluation, and learning, are highly relevant to the study of creativity and represent a stimulating challenge to investigators.     

Impairments of speech fluency in Lewy body spectrum disorder

Few studies have examined connected speech in demented and non-demented patients with Parkinson’s disease (PD). We assessed the speech production of 35 patients with Lewy body spectrum disorder (LBSD), including non-demented PD patients, patients with PD dementia (PDD), and patients with dementia with Lewy bodies (DLB), in a semi-structured narrative speech sample in order to characterize impairments of speech fluency and to determine the factors contributing to reduced speech fluency in these patients. Both demented and non-demented PD patients exhibited reduced speech fluency, characterized by reduced overall speech rate and long pauses between sentences. Reduced speech rate in LBSD correlated with measures of between-utterance pauses, executive functioning, and grammatical comprehension. Regression analyses related non-fluent speech, grammatical difficulty, and executive difficulty to atrophy in frontal brain regions. These findings indicate that multiple factors contribute to slowed speech in LBSD, and this is mediated in part by disease in frontal brain regions.     

Modifications in basal and stress-induced hypothalamic AMP-activated protein kinase (AMPK) activity in rats chronically treated with an angiotensin II receptor blocker

5' adenosine monophosphate-activated protein kinase (AMPK) plays a prominent role as a metabolic stress sensor. The role of hypothalamic AMPK in response to restraint and surgical stress has not been previously investigated. It has been recently suggested that the renin-angiotensin system, in addition to its role in stress regulation, may play a significant role in regulating metabolic pathways including the regulation of the AMPK system. This study was thus aimed to evaluate the effects of candesartan, an angiotensin II AT1 receptor blocker drug, on hypothalamic AMPK activity under basal conditions and after restraint in conscious rats or after surgical stress under general anesthesia. Male Wistar rats were treated with 5 mg/kg/day candesartan in the drinking water for 2 weeks. The hypothalamic AMPK activity was determined under basal and stress conditions, using a kinase activity assay. Chronic administration of candesartan significantly increased hypothalamic AMPK activity. Hypothalamic AMPK activity was also increased by restraint stress whereas no change was observed during surgical stress under anesthesia. The high levels of hypothalamic AMPK activation observed in candesartan-treated rats were not changed by restraint stress but were reduced to control levels by anesthesia and surgery. In conclusion, chronic candesartan treatment and restraint stress in conscious rats stimulate the hypothalamic AMPK activity, whereas surgical stress under anesthesia inhibits pathways regulating the AMPK activity even in candesartan-treated rats.     

REFLECTIONS ON A FEMINIST RESEARCH PROJECT

This article describes the group process in a feminist research project on resiliency in adult women survivors of childhood sexual abuse. Memos written by members of the research team that were content analyzed independently provided the major source of data. Researchers' subjectivity, members' expectations for intimacy, and the role of power were examined. We describe how group members learned that taking the researcher's subjectivity into account affected our understanding of participant stories. The longing for intimacy created frustrations that needed to be acknowledged and processed by the group. Further tensions revolved around the feminist ideal of egalitarian relationships, which at times conflicted with the need for efficient decision making. We conclude with suggestions to aid feminist researchers in negotiating process issues.