Sentence processing in Lewy body spectrum disorder: the role of working memory

Prior work has related sentence processing to executive deficits in non-demented patients with Parkinson's disease (PD). We extended this investigation to patients with dementia with Lewy bodies (DLB) and PD dementia (PDD) by examining grammatical and working memory components of sentence processing in the full range of patients with Lewy body spectrum disorder (LBSD). Thirty-three patients with LBSD were given a two-alternative, forced-choice sentence-picture matching task. Sentence type, working memory, and grammatical structure were systematically manipulated in the sentences. We found that patients with PDD and DLB were significantly impaired relative to non-demented PD patients and healthy controls. The deficit in PDD/DLB was most pronounced for sentences lengthened by the strategic placement of an additional prepositional phrase and for sentences with an additional proposition due to a center-embedded clause. However, there was no effect for subject-relative versus object-relative grammatical structure. An MRI voxel-based morphometry analysis in a subset of patients showed significant gray matter thinning in the frontal lobe bilaterally, and this extended to temporal, parietal and occipital regions. A regression analysis related sentence processing difficulty in LBSD to frontal neocortex, including inferior prefrontal, premotor, and dorsolateral prefrontal regions, as well as right superior temporal cortex. These findings are consistent with the hypothesis that patients with PDD and DLB have difficulty processing sentences with increased working memory demands and that this deficit is related in part to their frontal disease.     

Youth Initiated Mentoring: Investigating a New Approach to Working with Vulnerable Adolescents

This study examines youth initiated mentoring (YIM), a new approach to mentoring in which youth nominate mentors from among the non-parental adults within their existing social networks (e.g., teachers, family friends, extended family members). YIM is currently being implemented through the National Guard Youth ChalleNGe Program (NGYCP), an intensive residential intervention program for youth ages 16–18 who have dropped out or been expelled from high school. This study employed a mixed methods explanatory design, drawing on quantitative data from a national longitudinal evaluation of NGYCP (N = 1,173) and qualitative data from a subsample of participants (N = 30) in the evaluation. Results indicated that more enduring mentoring relationships were associated with increased retention of educational, vocational, and behavioral outcomes 3 years following entry into the study. Qualitative data suggested that, when relationships endured, mentors contributed to improvements in participants’ educational and occupational success, quality of relationships with parents, peers, and others, and self-concept by providing social-emotional support, instrumental support, and guidance. Results also revealed that relationships were more likely to endure when youth chose their mentors on their own (rather than receiving help from parents or program staff) and when mentors were of the same race as youth. Implications for research and practice are discussed.     

Verb agreements during on-line sentence processing in Alzheimer's disease and frontotemporal dementia

An on-line "word detection" paradigm was used to assess the comprehension of thematic and transitive verb agreements during sentence processing in individuals diagnosed with probable Alzheimer's Disease (AD, n=15) and Frontotemporal Dementia (FTD, n=14). AD, FTD, and control participants (n=17) were asked to listen for a word in a sentence. Unbeknownst to the participants, the target word followed an agreement involving a verb's transitivity or thematic role component. Control participants took significantly longer to respond to a target word only when it immediately followed a violation of a thematic role agreement or a transitivity agreement, relative to target word detection immediately following the corresponding correct agreement. AD patients were selectively insensitive to thematic role agreement violations, although they demonstrated a normal processing pattern for transitivity agreements. This is consistent with previous observations showing selective difficulty with the thematic role component of a verb in AD. FTD patients were insensitive to violations of thematic role and transitivity agreements. FTD patients' impairment for both transitivity and thematic role agreements may reflect a broader degradation of verb knowledge that involves both grammatical and semantic representations, or difficulty processing sentence structure that also causes a thematic role deficit.     

Proper and common nouns: form class judgments in Broca's aphasia

Studies of agrammatic Broca's aphasics' comprehension of sentences containing articles have demonstrated profound deficits. It has not been clear whether the impairments are due to an inability to isolate the article in the stream of speech, or to difficulty in the construction and/or interpretation of various syntactic, semantic, or pragmatic levels of representation. This paper reports three experiments on Broca's aphasics' ability to distinguish between common nouns (e.g., "a rose") and proper nouns (e.g., "Rose"). This grammatical form class decision is signaled by the presence or absence of an article, and is represented at the lexical node level of linguistic analysis. The three experiments demonstrated that Broca's aphasics point to pictures representing classes of objects when asked to point to "the X" and point to pictures representing unique individuals when asked to point to "X". Thus, they were shown to be able to use the presence or absence of an article to determine lexical category. Their performance was especially accurate in an oral language context which was highly redundant and in a written language context where patients themselves could control the rate of information flow. They were quantitatively impaired, relative to controls, in a third study, which made higher information processing demands. Moreover, in this third study nonsense syllables preceding the noun which are phonologically similar to a known article were much more likely to evoke the misclassification of its noun as common than were phonologically distinct nonsense syllables. These data indicate that Broca's aphasics indeed have some difficulty isolating the article in the stream of speech. Nevertheless, detailed analyses of aphasics' performance revealed their ability to distinguish between common nouns and proper nouns even under these demanding conditions. Taken together, the three studies show that insofar as agrammatic patients are able to keep track of the presence or absence of articles, they can make a grammatical decision at the lexical node level of linguistic analysis. We conclude, then, that agrammatic Broca's aphasics are particularly impaired in the use of articles to construct and/or interpret phrasal constituents.     

Pursuing a Comprehensive Faculty Development Program: Making Fragmentation Work

Arizona State University (ASU) serves as a case study of a comprehensive faculty development program in a large university characterized by numerous overlapping and fragmented resources and services. In this setting, the task of faculty development is to provide the leadership that is necessary to mold these fragments into a coherent vision and mission that promotes the aims of the university and supports the needs of the faculty. Programs based on the consortium, the cooperative, and the distributed models make fragmentation work for, rather than against, the program. In addition, faculty development must work to establish an academic environment that values teaching, research, and scholarly outreach—the constituent elements of a comprehensive program.     

Gender Differences and Sexism in the Knowledge and Use of Slang

Gender differences and sexism in the knowledge and use of slang were investigated. Thirty male and thirty female undergraduates (mostly Caucasian and middle-class) reported all the slang terms they knew to describe either woman or man, how many terms they used, and how frequently they used them. The terms were categorized as sexual or non-sexual Males listed more terms than females, but no gender differences were found in the listing of sexual slang or the use of slang. More sexual slang was listed to describe women than men, and participants reported using fewer of the terms describing women. Results suggest that although gender differences in the knowledge and use of slang may be narrowing, it remains the case that more sexual and derogatory slang exists to describe women.     

The evaluation of truthfulness in alleged sex offenders' self-reports: 16PF and MMPI validity scales.

The evaluation of response bias (i.e., minimization or exaggeration) is central to forensic psychological evaluations. Yet few studies have assessed forensic samples to investigate the ability of psychological tests to detect response bias. We studied the relationship between the Sixteen Personality Factors Questionnaire (16PF) and the Minnesota Multiphasic Personality Inventory (MMPI) validity scales for 65 alleged sex offenders and assessed the effects of different cutoff scores for the 16PF validity scales. Results indicate consistent significant correlations between the validity scales of the 16PF and the MMPI for measures of minimization and exaggeration. use of a priori cutoff scores resulted in the classification of our sample in proportions parallel to those found in previous research for the 16PF Fake-Good scale but not the Fake-Bad scale. Our results indicate that 16PF validity scales are useful, but interpretations must take into account different base rates of response bias between sex offenders and the general population.     

Differences in encoding for free recall vs. recognition

Three experiments examined effects of test expectancy on memory for relatively unrelated words. In Experiment I, where preliminary recall or recognition practice was given, both recall and recognition were superior when the subjects expected and had practiced for recall. Free study led to better recall and recognition than paced presentation, but did not interact with test expectancy. Experiment II demonstrated that recall was better for subjects expecting a recall vs. a recognition test in the absence of preliminary practice. In Experiment III all subjects practiced both recall and recognition prior to presentation of the critical list. Study time also was varied. With longer study, recall was better when a recall test was expected, with no test expectancy effect on recognition. There were no appreciable expectancy effects with the short study period. Self-reports and other data suggested that the critical encoding differences produced by test expectancy manipulation were quantitative in nature.