Movements execution in amnestic mild cognitive impairment and Alzheimer's disease

We evaluated the relationship between motor and neuropsychological deficits in subjects affected by amnestic Mild Cognitive Impairment (aMCI) and early Alzheimer's Disease (AD). Kinematics of goal-directed movement of aMCI and AD subjects were compared to those of age-matched control subjects. AD showed a slowing down of motor performance compared to aMCI and controls. No relationships were found between motor and cognitive performances in both AD and aMCI. Our results suggest that the different motor behaviour between AD and aMCI cannot be related to memory deficits, probably reflecting the initial degeneration of parietal-frontal circuits for movement planning. The onset of motor dysfunction in early AD could represent the transition from aMCI to AD.     

Universal sex differences in the desire for sexual variety: tests from 52 nations, 6 continents,and 13 islands

Evolutionary psychologists have hypothesized that men and women possess both long-term and short-term mating strategies, with men's short-term strategy differentially rooted in the desire for sexual variety. In this article, findings from a cross-cultural survey of 16,288 people across 10 major world regions (including North America, South America, Western Europe, Eastern Europe, Southern Europe, Middle East, Africa, Oceania, South/Southeast Asia, and East Asia) demonstrate that sex differences in the desire for sexual variety are culturally universal throughout these world regions. Sex differences were evident regardless of whether mean, median, distributional, or categorical indexes of sexual differentiation were evaluated. Sex differences were evident regardless of the measures used to evaluate them. Among contemporary theories of human mating, pluralistic approaches that hypothesize sex differences in the evolved design of short-term mating provide the most compelling account of these robust empirical findings.     

Integrating Exposure and Response Prevention With a Mobile App to Treat Obsessive-Compulsive Disorder: Feasibility,Acceptability, and Preliminary Effects

Many individuals with obsessive-compulsive disorder (OCD) do not receive evidence-based care (specifically exposure and ritual prevention; EX/RP) due to barriers such as a lack of EX/RP-trained clinicians, geographic obstacles, and the cost and time associated with the treatment. Offering an integrated treatment model consisting of brief in-person therapy coupled with a mobile application (app) might be one way to increase access to and reduce the time burden (to clinicians and patients) of EX/RP. This pilot trial evaluated the feasibility, acceptability, and clinical effects of such a treatment program for adults with OCD. Thirty-three participants enrolled in the 8-week open trial. The integrated treatment program consisted of 3 to 5 in-person sessions followed by weekly phone calls supported by a mobile app (nOCD). Participants were evaluated by trained raters and completed self-report measures at baseline, midtreatment, posttreatment and 2-month follow-up; the Yale-Brown Obsessive-Compulsive Scale (Y-BOCS) was the primary outcome. This integrated treatment program was feasible and acceptable to participants. Of the 33 study entrants, 14 (42%) responded to treatment (Y-BOCS decrease ≥ 35% with CGI- of 1 or 2), and 8 (24%) achieved minimal symptoms (i.e., Y-BOCS ≤ 12). At 2-month follow-up (n = 20), 7/20 (35%) met criteria for treatment response, and 3/20 (15.0%) met criteria for treatment remission. Although preliminary, this model warrants further study as an efficacious and resource-efficient way to deliver EX/RP for some patients with OCD.     

When and why do retrieval attempts enhance subsequent encoding?

Unsuccessful retrieval attempts can enhance subsequent encoding and learning. In three experiments, subjects either attempted to retrieve word pairs prior to studying them (e.g., attempting to recall tide–? before studying tide–beach) or did not attempt retrieval and retention of the studied targets was assessed on a subsequent cued recall test. Experiment 1 showed that attempting retrieval enhanced subsequent encoding and recall relative to not attempting retrieval when the word pairs were semantically related, but not when the pairs were unrelated. In Experiment 2, studying a different word pair prior to the correct pair (e.g., studying tide–wave prior to tide–beach) did not produce the same effect as attempting retrieval prior to studying. Constraining retrieval to a particular candidate word prior to study (e.g., recalling tide–wa__ before studying tide–beach) produced a negative effect on subsequent recall. Experiment 3 showed that attempting retrieval did not enhance encoding when a brief delay occurred between the retrieval attempt and the subsequent study trial. The results support the idea that a search set of candidates related to the retrieval cue is activated during retrieval and that this retrieval-specific activation can enhance subsequent encoding of those candidates.     

Uncovering the connection between artist and audience: Viewing painted brushstrokes evokes corresponding action representations in the observer

Observed actions are covertly and involuntarily simulated within the observer’s motor system. It has been argued that simulation is involved in processing abstract, gestural paintings, as the artist’s movements can be simulated by observing static brushstrokes. Though this argument is grounded in theory, empirical research has yet to examine the claim. Five experiments are described wherein participants executed arm movements resembling the act of painting horizontal brushstrokes while observing paintings featuring broad, discernable brushstrokes. Participants responded faster when their movement was compatible with the observed brushstrokes, even though the paintings were irrelevant to their task. Additional results suggest that this effect occurs outside of awareness. These results provide evidence that observers can simulate the actions of the painter by simply observing the painting, revealing a connection between artist and audience hitherto undemonstrated by cognitive science.