No More Away: Techno-Attachments and the Relational Future

This paper speculates about the impact of techno-connectedness on our children, ourselves, our grandchildren. Triggered by recollections from Victorian novels that describe European summers “away” from home, a concern about loss of opportunity, the “space” for self-discovery in this young generation will be explored in a relational context. Brought about by pervasive dependence upon computer technology, is self-experience fragmented and attachment changed by the ubiquitous technological presence and is the more isolated, reflective experience being eroded?     

Cancer Risk Assessment Using Genetic Panel Testing: Considerations for Clinical Application

With the completion of the Human Genome Project and the development of high throughput technologies, such as next-generation sequencing, the use of multiplex genetic testing, in which multiple genes are sequenced simultaneously to test for one or more conditions, is growing rapidly. Reflecting underlying heterogeneity where a broad range of genes confer risks for one or more cancers, the development of genetic cancer panels to assess these risks represents just one example of how multiplex testing is being applied clinically. There are a number of issues and challenges to consider when conducting genetic testing for cancer risk assessment, and these issues become exceedingly more complex when moving from the traditional single-gene approach to panel testing. Here, we address the practical considerations for clinical use of panel testing for breast, ovarian, and colon cancers, including the benefits, limitations and challenges, genetic counseling issues, and management guidelines.     

Geometrical representation of two methods of linear least squares multiple correlation

Geometrical properties and relationships of the Doolittle and square root methods of multiple correlation, as represented in the variable subspace of an orthogonal person space, are shown. The method of representation is also useful for depicting zero-order and partial correlations, as well as for the more general problem of the combination of variables.     

Nietzsche for beginners

Writers and Readers Publishing, USA, 1990