A Clinical Decision Support Tool to Predict Cancer Risk for Commonly Tested Cancer-Related Germline Mutations

The rapid drop in the cost of DNA sequencing led to the availability of multi-gene panels, which test 25 or more cancer susceptibility genes for a low cost. Clinicians and genetic counselors need a tool to interpret results, understand risk of various cancers, and advise on a management strategy. This is challenging as there are multiple studies regarding each gene, and it is not possible for clinicians and genetic counselors to be aware of all publications, nor to appreciate the relative accuracy and importance of each. Through an extensive literature review, we have identified reliable studies and derived estimates of absolute risk. We have also developed a systematic mechanism and informatics tools for (1) data curation, (2) the evaluation of quality of studies, and (3) the statistical analysis necessary to obtain risk. We produced the risk prediction clinical decision support tool ASK2ME (All Syndromes Known to Man Evaluator). It provides absolute cancer risk predictions for various hereditary cancer susceptibility genes. These predictions are specific to patients’ gene carrier status, age, and history of relevant prophylactic surgery. By allowing clinicians to enter patient information and receive patient-specific cancer risks, this tool aims to have a significant impact on the quality of precision cancer prevention and disease management activities relying on panel testing. It is important to note that this tool is dynamic and constantly being updated, and currently, some of its limitations include (1) for many gene-cancer associations risk estimates are based on one study rather than meta-analysis, (2) strong assumptions on prior cancers, (3) lack of uncertainty measures, and (4) risk estimates for a growing set of gene-cancer associations which are not always variant specific. All of these concerns are being addressed on an ongoing basis, aiming to make the tool even more accurate.     

Exploring Associations Among African American Youths' Perceptions of Racial Fairness and School Engagement: Does Gender Matter?

In addition to experiencing race as a unique social milieu within school, gender may also provide an important context for African American students. The authors explored gender differences in associations between African American youths' perceptions of racial fairness and school engagement (behavioral, emotional, and cognitive). One hundred thirty-nine (72 girls, 67 boys) African American high schoolers were recruited from the southeastern region of the United States. Gender differences were found for neither perceptions of racial fairness nor emotional and cognitive engagement. Girls reported higher behavior engagement relative to boys. Also, racial fairness was positively associated with emotional engagement among girls. For boys, racial fairness related positively to the three engagement dimensions. Implications and resources relevant for school psychology practice are discussed.     

Brandom and the brutes

Brandom’s inferentialism offers, in many ways, a radically new approach to old issues in semantics and the theory of intentionality. But, in one respect at least, it clings tenaciously to the mainstream philosophical tradition of the middle years of the twentieth century. Against the theory’s natural tendencies, Brandom aligns it with the ’linguistic turn’ that philosophy took in the middle of the last century by insisting, in the face of considerable opposing evidence, that intentionality is the preserve of those who can offer and ask for reasons and thus of language users alone. In this paper, I argue that there is no good reason for giving inferentialism a linguistic twist, and that, in doing so, Brandom is forced to make claims which are implausible in themselves and lead him, in the attempt to mitigate them, to a number of doubtful expedients.     

Perpetrators’ reactions to perceived interpersonal wrongdoing: The associations of guilt and shame with forgiving,punishing, and excusing oneself

We describe a model in which guilt and shame associate with reactions to wrongdoing among perpetrators of interpersonal harm. Individuals who reported wronging another person (N = 410) completed measures of perceived transgression severity, guilt and shame, and possible reactions to perpetration of wrongdoing (i.e., forgiving, punishing, and excusing oneself). Guilt positively predicted forgiving and punishing oneself, and negatively predicted excusing oneself of blame. Shame, in contrast, negatively predicted forgiving oneself and positively predicted punishing and excusing oneself. The observed patterns of associations between guilt and shame with perpetrators’ reactions to wrongdoing provide further support for the dual-process model of self-forgiveness. Implications for future basic and applied investigations are discussed.     

How positive processes function in negative relationships: Dispositional gratitude moderates the association between affective need and frequency of dating violence victimization

Evidence indicates that dispositional gratitude may improve romantic relationships by reinforcing positive emotions between partners and by increasing awareness of affective needs, such as receiving emotional support, nurturance, and reassurance. However, little research has investigated the influence of gratitude on relationships characterized by violence. In the present study, participants (N = 421) completed a cross-sectional survey of experiences with dating violence, dispositional gratitude, and affective need. Data were analyzed using structural equation modeling. Among individuals with lower rates of dispositional gratitude, higher levels of affective need were associated with lower frequency of dating violence victimization. However, among individuals with higher rates of dispositional gratitude, there was no evidence to suggest an association between affective need and frequency of victimization. These preliminary findings compel further investigation of how positive processes impact the perceived qualities of negative romantic relationships.     

Allowing for correlations between correlations in random-effects meta-analysis of correlation matrices

Practical meta-analysis of correlation matrices generally ignores covariances (and hence correlations) between correlation estimates. The authors consider various methods for allowing for covariances, including generalized least squares, maximum marginal likelihood, and Bayesian approaches, illustrated using a 6-dimensional response in a series of psychological studies concerning prediction of exercise behavior change. Quantities of interest include the overall population mean correlation matrix, the contrast between the mean correlations, the predicted correlation matrix in a new study, and the conflict between the existing studies and a new correlation matrix. The authors conclude that accounting for correlations between correlations is unnecessary when interested in individual correlations but potentially important if concerned with a composite measure involving 2 or more correlations. A simulation study indicates the asymptotic normal assumption appears reasonable. Because of potential instability in the generalized least squares methods, they recommend a model-based approach, either the maximum marginal likelihood approach or a full Bayesian analysis.     

Four Brief Studies of Relations Between Postformal Thought and Non-Cognitive Factors: Personality, Concepts of God, Political Opinions, and Social Attitudes

This is a report of four studies extending research on Complex Postformal Thought using the Postformal Thought Scale (PTS) (Sinnott 1998a, b). In Study I PTS was studied in relation to personality as conceptualized in the NEO Five Factor Model. Data from 82 participants indicated that PTS is significantly related to the Openness to Experience and the Conscientiousness factors of the NEO. In Study II PTS was examined in relation to the Concept of God Scale to answer the question whether postformal and non-postformal respondents were likely to hold different god concepts. Data from 50 participants indicated no relationship between the two measures. In Study III PTS was examined in relation to political opinions using the newly created Political Opinion Survey. Data from 50 participants demonstrated no relation between the two tests. In Study IV PTS was studied in relation to the Attitudes Toward Lesbians and Gay Men Scale. Data from 112 participants indicated that PTS was related to positive attitudes toward lesbians and gay men. Current conceptualizations of PTS development are used to interpret these findings.     

Evaluating sources of baseline data using dual-criteria and conservative dual-criteria methods: A quantitative analysis

Scheithauer et al. (2020) recently demonstrated that differences in the source of baseline data extracted from a functional analysis (FA) may not affect subsequent clinical decision-making in comparison to a standard baseline. These outcomes warrant additional quantitative examination, as correspondence of visual analysis has sometimes been reported to be unreliable. In the current study, we quantified the occurrence of false positives within a dataset of FA and baseline data using the dual-criteria (DC) and conservative dual-criteria (CDC) methods. Results of this quantitative analysis suggest that false positives were more likely when using FA data (rather than original baseline data) as the initial treatment baseline. However, both sources of baseline data may have acceptably low levels of false positives for practical use. Overall, the findings provide preliminary quantitative support for the conclusion that determinations of effective treatment may be easily obtained using different sources of baseline data.     

The inhibitory control of pheasants (Phasianus colchicus) weakens when previously learned environmental information becomes unpredictable

Animal Cognition - Inhibitory control (IC) is the ability to intentionally restrain initial, ineffective responses to a stimulus and instead exhibit an alternative behaviour that is not pre-potent...